Connective tissue growth factor: Role in trabecular meshwork remodeling and intraocular pressure lowering
Connective tissue growth factor (CTGF) is a distinct signaling molecule modulating many physiological and pathophysiological processes. This protein is upregulated in numerous fibrotic diseases that involve extracellular matrix (ECM) remodeling. It mediates the downstream effects of transforming gro...
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2023
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2-s2.0-85174632034 Hassan M.D.S.; Razali N.; Abu Bakar A.S.; Abu Hanipah N.F.; Agarwal R. Connective tissue growth factor: Role in trabecular meshwork remodeling and intraocular pressure lowering 2023 Experimental Biology and Medicine 248 16 10.1177/15353702231199466 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85174632034&doi=10.1177%2f15353702231199466&partnerID=40&md5=7ab652b0d7dd1f5e741fd85a5f5243c9 Connective tissue growth factor (CTGF) is a distinct signaling molecule modulating many physiological and pathophysiological processes. This protein is upregulated in numerous fibrotic diseases that involve extracellular matrix (ECM) remodeling. It mediates the downstream effects of transforming growth factor beta (TGF-β) and is regulated via TGF-β SMAD-dependent and SMAD-independent signaling routes. Targeting CTGF instead of its upstream regulator TGF-β avoids the consequences of interfering with the pleotropic effects of TGF-β. Both CTGF and its upstream mediator, TGF-β, have been linked with the pathophysiology of glaucomatous optic neuropathy due to their involvement in the regulation of ECM homeostasis. The excessive expression of these growth factors is associated with glaucoma pathogenesis via elevation of the intraocular pressure (IOP), the most important risk factor for glaucoma. The raised in the IOP is due to dysregulation of ECM turnover resulting in excessive ECM deposition at the site of aqueous humor outflow. It is therefore believed that CTGF could be a potential therapeutic target in glaucoma therapy. This review highlights the CTGF biology and structure, its regulation and signaling, its association with the pathophysiology of glaucoma, and its potential role as a therapeutic target in glaucoma management. © 2023 by the Society for Experimental Biology and Medicine. SAGE Publications Inc. 15353702 English Review All Open Access; Green Open Access |
author |
Hassan M.D.S.; Razali N.; Abu Bakar A.S.; Abu Hanipah N.F.; Agarwal R. |
spellingShingle |
Hassan M.D.S.; Razali N.; Abu Bakar A.S.; Abu Hanipah N.F.; Agarwal R. Connective tissue growth factor: Role in trabecular meshwork remodeling and intraocular pressure lowering |
author_facet |
Hassan M.D.S.; Razali N.; Abu Bakar A.S.; Abu Hanipah N.F.; Agarwal R. |
author_sort |
Hassan M.D.S.; Razali N.; Abu Bakar A.S.; Abu Hanipah N.F.; Agarwal R. |
title |
Connective tissue growth factor: Role in trabecular meshwork remodeling and intraocular pressure lowering |
title_short |
Connective tissue growth factor: Role in trabecular meshwork remodeling and intraocular pressure lowering |
title_full |
Connective tissue growth factor: Role in trabecular meshwork remodeling and intraocular pressure lowering |
title_fullStr |
Connective tissue growth factor: Role in trabecular meshwork remodeling and intraocular pressure lowering |
title_full_unstemmed |
Connective tissue growth factor: Role in trabecular meshwork remodeling and intraocular pressure lowering |
title_sort |
Connective tissue growth factor: Role in trabecular meshwork remodeling and intraocular pressure lowering |
publishDate |
2023 |
container_title |
Experimental Biology and Medicine |
container_volume |
248 |
container_issue |
16 |
doi_str_mv |
10.1177/15353702231199466 |
url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85174632034&doi=10.1177%2f15353702231199466&partnerID=40&md5=7ab652b0d7dd1f5e741fd85a5f5243c9 |
description |
Connective tissue growth factor (CTGF) is a distinct signaling molecule modulating many physiological and pathophysiological processes. This protein is upregulated in numerous fibrotic diseases that involve extracellular matrix (ECM) remodeling. It mediates the downstream effects of transforming growth factor beta (TGF-β) and is regulated via TGF-β SMAD-dependent and SMAD-independent signaling routes. Targeting CTGF instead of its upstream regulator TGF-β avoids the consequences of interfering with the pleotropic effects of TGF-β. Both CTGF and its upstream mediator, TGF-β, have been linked with the pathophysiology of glaucomatous optic neuropathy due to their involvement in the regulation of ECM homeostasis. The excessive expression of these growth factors is associated with glaucoma pathogenesis via elevation of the intraocular pressure (IOP), the most important risk factor for glaucoma. The raised in the IOP is due to dysregulation of ECM turnover resulting in excessive ECM deposition at the site of aqueous humor outflow. It is therefore believed that CTGF could be a potential therapeutic target in glaucoma therapy. This review highlights the CTGF biology and structure, its regulation and signaling, its association with the pathophysiology of glaucoma, and its potential role as a therapeutic target in glaucoma management. © 2023 by the Society for Experimental Biology and Medicine. |
publisher |
SAGE Publications Inc. |
issn |
15353702 |
language |
English |
format |
Review |
accesstype |
All Open Access; Green Open Access |
record_format |
scopus |
collection |
Scopus |
_version_ |
1809678155808505856 |