Two new flavonols from Macaranga inermis pax & K.Hoffm
Four isoprenylated flavonols, including two new compounds, macainermisins A-B (1-2), and two known compounds, sinoflavonoid P (3), broussoflavonol F (4), were isolated from the leaves of Macaranga inermis. A combination of HRESIMS, UV, 1D, and 2D NMR spectra elucidated the structures of 1-2. Flavono...
| Published in: | Natural Product Research |
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| Format: | Article |
| Language: | English |
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Taylor and Francis Ltd.
2025
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85174606227&doi=10.1080%2f14786419.2023.2272783&partnerID=40&md5=5d69148aba8f7a8d9b157403eea54858 |
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2-s2.0-85174606227 Tanjung M.; Tjahjandarie T.S.; Aldin M.F.; Mardhiyyah S.; Saputri R.D.; Syah Y.M.; Ahmat N. Two new flavonols from Macaranga inermis pax & K.Hoffm 2025 Natural Product Research 39 3 10.1080/14786419.2023.2272783 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85174606227&doi=10.1080%2f14786419.2023.2272783&partnerID=40&md5=5d69148aba8f7a8d9b157403eea54858 Four isoprenylated flavonols, including two new compounds, macainermisins A-B (1-2), and two known compounds, sinoflavonoid P (3), broussoflavonol F (4), were isolated from the leaves of Macaranga inermis. A combination of HRESIMS, UV, 1D, and 2D NMR spectra elucidated the structures of 1-2. Flavonols (1-4) were evaluated against three cancer cells. Compound 1 showed high cytotoxicity against WiDR with an IC50 value of 0.93 µM, and compound 2 was active towards HeLa and WiDR (IC50 values of 0.90 and 0.94 µM), and compound 3 showed high activity towards 4T1 and HeLa (IC50 values of 0.83 and 0.98 µM). © 2023 Informa UK Limited, trading as Taylor & Francis Group. Taylor and Francis Ltd. 14786419 English Article |
| author |
Tanjung M.; Tjahjandarie T.S.; Aldin M.F.; Mardhiyyah S.; Saputri R.D.; Syah Y.M.; Ahmat N. |
| spellingShingle |
Tanjung M.; Tjahjandarie T.S.; Aldin M.F.; Mardhiyyah S.; Saputri R.D.; Syah Y.M.; Ahmat N. Two new flavonols from Macaranga inermis pax & K.Hoffm |
| author_facet |
Tanjung M.; Tjahjandarie T.S.; Aldin M.F.; Mardhiyyah S.; Saputri R.D.; Syah Y.M.; Ahmat N. |
| author_sort |
Tanjung M.; Tjahjandarie T.S.; Aldin M.F.; Mardhiyyah S.; Saputri R.D.; Syah Y.M.; Ahmat N. |
| title |
Two new flavonols from Macaranga inermis pax & K.Hoffm |
| title_short |
Two new flavonols from Macaranga inermis pax & K.Hoffm |
| title_full |
Two new flavonols from Macaranga inermis pax & K.Hoffm |
| title_fullStr |
Two new flavonols from Macaranga inermis pax & K.Hoffm |
| title_full_unstemmed |
Two new flavonols from Macaranga inermis pax & K.Hoffm |
| title_sort |
Two new flavonols from Macaranga inermis pax & K.Hoffm |
| publishDate |
2025 |
| container_title |
Natural Product Research |
| container_volume |
39 |
| container_issue |
3 |
| doi_str_mv |
10.1080/14786419.2023.2272783 |
| url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85174606227&doi=10.1080%2f14786419.2023.2272783&partnerID=40&md5=5d69148aba8f7a8d9b157403eea54858 |
| description |
Four isoprenylated flavonols, including two new compounds, macainermisins A-B (1-2), and two known compounds, sinoflavonoid P (3), broussoflavonol F (4), were isolated from the leaves of Macaranga inermis. A combination of HRESIMS, UV, 1D, and 2D NMR spectra elucidated the structures of 1-2. Flavonols (1-4) were evaluated against three cancer cells. Compound 1 showed high cytotoxicity against WiDR with an IC50 value of 0.93 µM, and compound 2 was active towards HeLa and WiDR (IC50 values of 0.90 and 0.94 µM), and compound 3 showed high activity towards 4T1 and HeLa (IC50 values of 0.83 and 0.98 µM). © 2023 Informa UK Limited, trading as Taylor & Francis Group. |
| publisher |
Taylor and Francis Ltd. |
| issn |
14786419 |
| language |
English |
| format |
Article |
| accesstype |
|
| record_format |
scopus |
| collection |
Scopus |
| _version_ |
1825722577356587008 |