THE ANTIOXIDANT MECHANISM IN THE PREVENTION OF TYPE 2 DIABETES AND ITS COMPLICATIONS: A NARRATIVE REVIEW

• Published in: Journal of Health and Translational Medicine
• Main Author: Mahmudur Rahman A.H.M.; Ibrahim F.S.; Amom Z.; Amran A.A.
• Format: Review
• Language: English
• Published: Faculty of Medicine, University of Malaya 2023
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85172710571&doi=10.22452%2fjummec.sp2023no2.45&partnerID=40&md5=b26eee264d25e7248449cd44ff6fd851

Type 2 diabetes mellitus (T2DM) is considered a chronic metabolic disease in which oxidative stress plays a vital part in the pathogenesis of diabetes. Essentially, hyperglycemia instigates the auto-oxidation of glucose to free radicals. The free radicals overwhelm endogenous antioxidant defense in macrovascular and microvascular dysfunctions. The antioxidants (such as vitamin C and α-lipoic acid) effectively reduce diabetic complications; they are used to treat and decrease the complication of diabetes mellitus. Supplementations with antioxidants and medicinal plants that possess antioxidant activity have been investigated for hypoglycemic effects. This review article sums up the role and mechanism of antioxidants in the prevention of T2DM and its complications. © 2023, Faculty of Medicine, University of Malaya. All rights reserved.