Synthesis and diverse biological activities of substituted indole β-carbolines: a review

QR Code

Synthesis and diverse biological activities of substituted indole β-carbolines: a review

β-Carboline bearing indole is one of the heterocyclic compounds that play a vital role in medicinal chemistry with various pharmacological effects such as anticancer, anti-acetylcholinesterase, anti-inflammation, antimalarial, antibacterial, anti-diabetic, and antioxidant. Over the last two decades,...

Full description

Bibliographic Details
Published in:	Natural Product Research
Main Author:	Zulkifli S.Z.; Pungot N.H.; Saaidin A.S.; Jani N.A.; Mohammat M.F.
Format:	Review
Language:	English
Published:	Taylor and Francis Ltd. 2024
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85172455188&doi=10.1080%2f14786419.2023.2261141&partnerID=40&md5=ad36b804de41d9afdf0ac8fef02db365

Similar Items

Anti-inflammatory Activity of 1-Substituted Glyoxal β-Carboline Derivatives
by: Zulkifli S.Z.; Asha'ari N.A.N.; Aziz A.F.A.; Pungot N.H.
Published: (2024)

Anti-inflammatory Activity of 1-Substituted Glyoxal β- Carboline Derivatives
by: Zulkifli, et al.
Published: (2024)

SYNTHESIS OF 4-ARYL SUBSTITUTED CANTHIN-6-ONE WITH β-CARBOLINE SKELETON VIA PICTET-SPENGLER CONDENSATION AND CYCLIZATION REACTION; [Sintesis 4-Aril Gantian Kantin-6-One dengan Rangka β-Karbolina Melalui Kondensasi Pictet-Spengler dan Tindak Balas Kitaran]
by: Pungot N.H.; Tarmizi N.H.M.; Zulkifli S.Z.
Published: (2023)

Synthesis of indole analogs as potent β-glucuronidase inhibitors
by: Baharudin M.S.; Taha M.; Imran S.; Ismail N.H.; Rahim F.; Javid M.T.; Khan K.M.; Ali M.
Published: (2017)

Synthesis and biological evaluation of indole derivatives as α-amylase inhibitor
by: Imran S.; Taha M.; Selvaraj M.; Ismail N.H.; Chigurupati S.; Mohammad J.I.
Published: (2017)

The β-carboline analogs as a potent inhibitor for Alzheimer's Disease, molecular docking and dynamics simulation study
by: Taha M.; Rahim F.; Khan A.A.; Adalat B.; Imran S.; Alshehri J.M.; Ahmad A.; Khan K.M.; Shah S.A.A.; Uddin N.
Published: (2023)

Synthesis and biological profile of substituted benzimidazoles
by: Vashist N.; Sambi S.S.; Narasimhan B.; Kumar S.; Lim S.M.; Shah S.A.A.; Ramasamy K.; Mani V.
Published: (2018)

Synthesis, pharmacological screening & computational analysis of some 2-(1H-Indol-3-yl)-N'-[(un)substituted phenylmethylidene] acetohydrazides & 2-(1H-Indol-3-yl)-N'-[(un)substituted benzoyl/2-Thienylcarbonyl]acetohydrazides
by: Rubab K.; Abbasi M.A.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Ashraf M.; Qurat-Ul-Ain; Ahmad I.; Lodhi M.A.; Ghufran M.; Shahid M.; Fatima H.
Published: (2017)

Review on Synthesis of (S)-5-Benzylpyrrolidine-2,4-dione Derivatives with Substitution at C-3 Position by Employing Functional Groups Interconversion
by: Zulkifli M.; Pungot N.H.; Abdullah N.; Ash’ari N.A.N.; Shaameri Z.
Published: (2022)

Synthesis, β-glucuronidase inhibition and molecular docking studies of cyano-substituted bisindole hydrazone hybrids
by: Abid O.; Imran S.; Taha M.; Ismail N.H.; Jamil W.; Kashif S.M.; Khan K.M.; Yusoff J.
Published: (2021)

Molecular Docking and ADME Profiles of Hyrtiosulawesine Derivatives Targeting pfLDH: Exploring Potential as Antimalarial Agents
by: Zulkifli S.Z.; Abdul Aziz A.A.; Saaidin A.S.; Hamzah N.; Pungot N.H.
Published: (2024)

Synthesis of chromen-4-one-oxadiazole substituted analogs as potent β-glucuronidase inhibitors
by: Taha M.; Rahim F.; Ali M.; Khan M.N.; Alqahtani M.A.; Bamarouf Y.A.; Gollapalli M.; Farooq R.K.; Ali Shah S.A.; Ahmed Q.U.; Zakaria Z.A.
Published: (2019)

Synthesis and biological evaluation of novel N-arylidenequinoline-3-carbohydrazides as potent β-glucuronidase inhibitors
by: Taha M.; Sultan S.; Nuzar H.A.; Rahim F.; Imran S.; Ismail N.H.; Naz H.; Ullah H.
Published: (2016)

Novel indole based hybrid oxadiazole scaffolds with: N -(substituted-phenyl)butanamides: Synthesis, lineweaver-burk plot evaluation and binding analysis of potent urease inhibitors
by: Nazir M.; Abbasi M.A.; Aziz-Ur-Rehman; Siddiqui S.Z.; Raza H.; Hassan M.; Ali Shah S.A.; Shahid M.; Seo S.-Y.
Published: (2018)

Synthesis of 2,3-dioxo-5-(substituted)arylpyrroles and their 2-oxo-5-aryl-3-hydrazone pyrrolidine derivatives
by: Mohammat M.F.; Shaameri Z.; Hamzah A.S.
Published: (2009)

Synthesis and biological evaluation of substituted benzohydrazide Schiff base adduct as potential cholinesterase inhibitors
by: Zulfiqar A.; Khan I.U.; Nabi M.; Ullah H.; Iqbal N.; Zeb B.; Hussain A.; Khan D.; Rab A.; Junaid S.M.; Taha M.; Shah S.A.A.; Rahim F.
Published: (2024)

Synthesis and biological evaluation of substituted benzohydrazide Schiff base adduct as potential cholinesterase inhibitors
by: Zulfiqar, et al.
Published: (2024)

Multi-step synthesis, kinetics and in silico explorations of indole-Phenyl-1,2,4-triazole Bi-heterocyclic hybrids unified with 3-substituted benzamides as elastase inhibitors
by: Shakila; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Nazir M.; Muhammad S.; Raza H.; Shah S.A.A.; Shahid M.; Chaudhry A.R.; Kim S.J.
Published: (2025)

Synthesis of new S-substituted derivatives of 5-[3-(1H-indol-3-yl) propyl]-1, 3, 4-oxadiazol-2-ylhydrosulfide as suitable antibacterial and anticancer agents with moderate cytotoxicity
by: Nazir M.; Abbasi M.A.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.; Fatima H.; Iftikhar S.; Saleem R.S.Z.
Published: (2019)

Synthesis of alpha amylase inhibitors based on privileged indole scaffold
by: Noreen T.; Taha M.; Imran S.; Chigurupati S.; Rahim F.; Selvaraj M.; Ismail N.H.; Mohammad J.I.; Ullah H.; javid M.T.; Nawaz F.; Irshad M.; Ali M.
Published: (2017)

Synthesis of novel 3,4-fused pyrazolidinone γ-lactam bicyclic moieties from 2,3-dioxo-4-carboxy-5-(substituted)pyrrolidines
by: Rashid F.N.A.A.; Mohammat M.F.; Shaameri Z.; Hamzah A.S.
Published: (2019)

Synthesis, antimicrobial and cytotoxic evaluation of 4-(1-aryl-5-halo-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides
by: Kumar M.; Narasimhan B.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.
Published: (2017)

Multi-step synthesis, kinetics and in silico explorations of indole-Phenyl-1,2,4-triazole Bi-heterocyclic hybrids unified with 3-substituted benzamides as elastase inhibitors
by: Shakila; Abbasi, et al.
Published: (2025)

Synthesis of novel derivatives of 4-methylbenzimidazole and evaluation of their biological activities
by: Taha M.; Ismail N.H.; Jamil W.; Rashwan H.; Kashif S.M.; Sain A.A.; Adenan M.I.; Anouar E.H.; Ali M.; Rahim F.; Khan K.M.
Published: (2014)

Synthesis, antimicrobial, anticancer, antiviral evaluation and QSAR studies of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides
by: Kumar M.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.; Clercq E.D.; Narasimhan B.
Published: (2014)

Synthesis, α-amylase inhibitory potential and molecular docking study of indole derivatives
by: Taha M.; Baharudin M.S.; Ismail N.H.; Imran S.; Khan M.N.; Rahim F.; Selvaraj M.; Chigurupati S.; Nawaz M.; Qureshi F.; Vijayabalan S.
Published: (2018)

4-(1-Aryl-5-chloro-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides: Synthesis, antimicrobial, anticancer evaluation and QSAR studies
by: Kumar M.; Narasimhan B.; Kumar P.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.
Published: (2014)

Biological evaluation of synthetic α,β-unsaturated carbonyl based cyclohexanone derivatives as neuroprotective novel inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation
by: Zha G.-F.; Zhang C.-P.; Qin H.-L.; Jantan I.; Sher M.; Amjad M.W.; Hussain M.A.; Hussain Z.; Bukhari S.N.A.
Published: (2016)

Synthesis and β-glucuronidase inhibitory activity of 2-arylquinazolin-4(3H)-ones
by: Khan K.M.; Saad S.M.; Shaikh N.N.; Hussain S.; Fakhri M.I.; Perveen S.; Taha M.; Choudhary M.I.
Published: (2014)

A review on chemical constituents and biological activities of the genus beilschmiedia (Lauraceae)
by: Salleh W.M.N.H.W.; Ahmad F.; Yen K.H.; Zulkifli R.M.
Published: (2015)

Synthesis of benzimidazole derivatives as potent β-glucuronidase inhibitors
by: Taha M.; Ismail N.H.; Imran S.; Selvaraj M.; Rashwan H.; Farhanah F.U.; Rahim F.; Kesavanarayanan K.S.; Ali M.
Published: (2015)

The role of commonly used transition metals in total synthesis of indole alkaloids
by: Khan, et al.
Published: (2024)

The role of commonly used transition metals in total synthesis of indole alkaloids
by: Hannan Khan A.; Altaf S.; Rasool N.; Mubarik A.; Ahmad M.; Shah S.A.A.; Imran S.; Bajaber M.A.
Published: (2024)

4-(2-(1H-Benzo[d]imidazol-2-ylthio) acetamido)-N-(substituted phenyl)benzamides: Design, synthesis and biological evaluation
by: Tahlan S.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Narasimhan B.
Published: (2019)

Multi-step synthesis of indole-N-ethyltriazole hybrids amalgamated with N-arylated ethanamides: structure-activity relationship and mechanistic explorations through tyrosinase inhibition, kinetics and computational ascriptions
by: Shakila; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Nazir M.; Raza H.; Zafar A.; Shah S.A.A.; Shahid M.; Seo S.-Y.
Published: (2022)

Synthesis: Small library of hybrid scaffolds of benzothiazole having hydrazone and evaluation of their β-glucuronidase activity
by: Taha M.; Arbin M.; Ahmat N.; Imran S.; Rahim F.
Published: (2018)

Diastereoselective reduction of 2,3-dioxo-4-carboxy-5-substituted pyrrolidines using NaBH4/AcOH and heterogenous hydrogenation reactions
by: Mohammat M.F.; Mansor N.S.; Shaameri Z.; Hamzah A.S.
Published: (2015)

Synthesis, α-glucosidase inhibitory activity and in silico study of tris-indole hybrid scaffold with oxadiazole ring: As potential leads for the management of type-II diabetes mellitus
by: Taha M.; Rahim F.; Imran S.; Ismail N.H.; Ullah H.; Selvaraj M.; Javid M.T.; Salar U.; Ali M.; Khan K.M.
Published: (2017)

Synthesis, Pharmacological Evaluation and Molecular Docking Studies of N-[2-(1H-indol-3-yl)Acetyl]Arylsulfonohydrazides
by: Rubab K.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Ashraf M.; Qurat-ul-Ain; Lodhi M.A.; Khan F.A.; Shahid M.; Fatima H.; Ahmad I.
Published: (2021)

Synthesis of N-substituted acetamide derivatives of azinane-bearing 1,3,4-oxadiazole nucleus and screening for antibacterial activity
by: Iqbal K.; Jamal Q.; Iqbal J.; Afreen M.S.; Sandhu M.Z.A.; Dar E.; Farooq U.; Mushtaq M.F.; Arshad N.; Iqbal M.M.
Published: (2017)