| Summary: | Antibiotic residues are being continuously detected in the environmental and food matrices. Though the level of antibiotic residues is typically in minute concentration, adverse effects of these antibiotics on the environment and human health have been observed. Hence, there is a demand for simple, rapid, accurate, reliable, inexpensive, and selective sample preparation with high sensitivity and throughput analysis for antibiotic compounds. Conventional extraction techniques such as liquid-liquid extraction (LLE) and solid phase extraction (SPE) are commonly used for sample preparation. However, most of the LLE and SPE techniques suffer from several major drawbacks such as consuming a large amount of toxic organic solvents, being relatively expensive, involving multi-step, time-consuming, and tedious operation. Thus, to overcome these shortcomings, a number of new-generation materials have been developed for the purification and separation of analytes. Over the past few decades, cyclodextrin-based adsorbents have drawn worldwide attention as new-generation adsorbents for sample preparation and extraction due to their extraordinary physicochemical properties. Cyclodextrin is a family of cyclic oligosaccharides built by the hydrophilic outer wall and hydrophobic cavity. These unique properties are modified with chemical functionalization to enhance their extraction capability. This review outlined the recent application of the cyclodextrin-based adsorbent in the sample preparation techniques of a variety of matrices. These methods represent fast, modern, sensitive, and efficient approaches to detecting antibiotic compounds. In this review, several new sample preparation techniques incorporated with cyclodextrin-based adsorbent developed from 2015 – 2022 is discussed in terms of their analytical performance which includes their sensitivity and efficiency toward the extraction, preconcentration, and isolation of antibiotic compounds from various type of matrices. © 2023, Malaysian Society of Analytical Sciences. All rights reserved.
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