Synthesis and Computational Exploration of Morpholine Bearing Halogenated Sulfonamides as Potential Tyrosinase Inhibitors

• Published in: Chemistry and Biodiversity
• Main Author: Abbasi M.A.; Raza H.; Aziz-ur-Rehman; Siddiqui S.Z.; Muhammad S.; Khan F.M.; Shah S.A.A.; Al-Sehemi A.G.; Kim S.J.
• Format: Article
• Language: English
• Published: John Wiley and Sons Inc 2023
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85169592392&doi=10.1002%2fcbdv.202300257&partnerID=40&md5=3de00912aa5ab96709bf9e1c57b95a60

In the presented work, a new series of three different 4-((3,5-dichloro-2-[(2/4-halobenzyl)oxy]phenyl)sulfonyl)morpholines was synthesized and the structure of these compounds were corroborated by 1H-NMR & 13C-NMR studies. The in vitro results established all the three compounds as potent tyrosinase inhibitors relative to the standard. The Kinetics mechanism plots established that compound 8 inhibited the enzyme non-competitively. The inhibition constants Ki calculated from Dixon plots for this compound was 0.0025 μM. Additionally, computational techniques were used to explore electronic structures of synthesized compounds. Fully optimized geometries were further docked with tyrosinase enzyme for inhibition studies. Reasonably good binding/interaction energies and intermolecular interactions were obtained. Finally, drug likeness was also predicted using the rule of five (RO5) and Chemical absorption, distribution, metabolism, excretion, and toxicity (ADMET) characteristics. It is anticipated that current experimental and computational investigations will evoke the scientific interest of the research community for the above-entitled compounds. © 2023 Wiley-VHCA AG, Zurich, Switzerland.