How to select healthy sperm for intracytoplasmic sperm injection in samples with high sperm DNA fragmentation?

How to select healthy sperm for intracytoplasmic sperm injection in samples with high sperm DNA fragmentation?

The body of evidence supports the negative impact of increased sperm DNA fragmentation (SDF) on natural fertility as well as assisted reproduction conditions. High SDF has been correlated with low pregnancy and delivery rates following intrauterine insemination. Also, high SDF is accused of reducing...

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Published in:Panminerva Medica
Main Author: Garrido N.; Gül M.; Jindal S.; Vogiatzi P.; Saleh R.; Durairajanayagam D.; Parmegiani L.; Boitrelle F.; Colpi G.M.; Agarwal A.
Format: Review
Language:English
Published: Edizioni Minerva Medica 2023
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85164255522&doi=10.23736%2fS0031-0808.23.04870-X&partnerID=40&md5=4e4a7bac91603f2a5b37fc76a3cc97f0
id 2-s2.0-85164255522
spelling 2-s2.0-85164255522
Garrido N.; Gül M.; Jindal S.; Vogiatzi P.; Saleh R.; Durairajanayagam D.; Parmegiani L.; Boitrelle F.; Colpi G.M.; Agarwal A.
How to select healthy sperm for intracytoplasmic sperm injection in samples with high sperm DNA fragmentation?
2023
Panminerva Medica
65
2
10.23736/S0031-0808.23.04870-X
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85164255522&doi=10.23736%2fS0031-0808.23.04870-X&partnerID=40&md5=4e4a7bac91603f2a5b37fc76a3cc97f0
The body of evidence supports the negative impact of increased sperm DNA fragmentation (SDF) on natural fertility as well as assisted reproduction conditions. High SDF has been correlated with low pregnancy and delivery rates following intrauterine insemination. Also, high SDF is accused of reducing the rates of fertilization, implantation, pregnancy, and live birth following in-vitro fertilization (IVF). Despite no impact of high SDF on fertilization or pregnancy rates following intracytoplasmic sperm injection (ICSI), it has been correlated with poor embryo quality and a higher risk of miscarriage. Several methods have been introduced to help select sperm with the best DNA quality to be used in assisted reproductive technology procedures. These include magnetic-activated cell sorting, intracytoplasmic morphologically selected sperm injection, physiologic ICSI, and microfluidic sperm sorters, among others. This article aimed to discuss the impact of high SDF in infertile men on the reproductive outcome of couples undergoing IVF/ICSI. Additionally, this review highlights the principles, advantages, and limitations of different techniques that are currently used for the selection of sperm with intact DNA to be utilized for ICSI. © 2023 EDIZIONI MINERVA MEDICA.
Edizioni Minerva Medica
310808
English
Review
author Garrido N.; Gül M.; Jindal S.; Vogiatzi P.; Saleh R.; Durairajanayagam D.; Parmegiani L.; Boitrelle F.; Colpi G.M.; Agarwal A.
spellingShingle Garrido N.; Gül M.; Jindal S.; Vogiatzi P.; Saleh R.; Durairajanayagam D.; Parmegiani L.; Boitrelle F.; Colpi G.M.; Agarwal A.
How to select healthy sperm for intracytoplasmic sperm injection in samples with high sperm DNA fragmentation?
author_facet Garrido N.; Gül M.; Jindal S.; Vogiatzi P.; Saleh R.; Durairajanayagam D.; Parmegiani L.; Boitrelle F.; Colpi G.M.; Agarwal A.
author_sort Garrido N.; Gül M.; Jindal S.; Vogiatzi P.; Saleh R.; Durairajanayagam D.; Parmegiani L.; Boitrelle F.; Colpi G.M.; Agarwal A.
title How to select healthy sperm for intracytoplasmic sperm injection in samples with high sperm DNA fragmentation?
title_short How to select healthy sperm for intracytoplasmic sperm injection in samples with high sperm DNA fragmentation?
title_full How to select healthy sperm for intracytoplasmic sperm injection in samples with high sperm DNA fragmentation?
title_fullStr How to select healthy sperm for intracytoplasmic sperm injection in samples with high sperm DNA fragmentation?
title_full_unstemmed How to select healthy sperm for intracytoplasmic sperm injection in samples with high sperm DNA fragmentation?
title_sort How to select healthy sperm for intracytoplasmic sperm injection in samples with high sperm DNA fragmentation?
publishDate 2023
container_title Panminerva Medica
container_volume 65
container_issue 2
doi_str_mv 10.23736/S0031-0808.23.04870-X
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85164255522&doi=10.23736%2fS0031-0808.23.04870-X&partnerID=40&md5=4e4a7bac91603f2a5b37fc76a3cc97f0
description The body of evidence supports the negative impact of increased sperm DNA fragmentation (SDF) on natural fertility as well as assisted reproduction conditions. High SDF has been correlated with low pregnancy and delivery rates following intrauterine insemination. Also, high SDF is accused of reducing the rates of fertilization, implantation, pregnancy, and live birth following in-vitro fertilization (IVF). Despite no impact of high SDF on fertilization or pregnancy rates following intracytoplasmic sperm injection (ICSI), it has been correlated with poor embryo quality and a higher risk of miscarriage. Several methods have been introduced to help select sperm with the best DNA quality to be used in assisted reproductive technology procedures. These include magnetic-activated cell sorting, intracytoplasmic morphologically selected sperm injection, physiologic ICSI, and microfluidic sperm sorters, among others. This article aimed to discuss the impact of high SDF in infertile men on the reproductive outcome of couples undergoing IVF/ICSI. Additionally, this review highlights the principles, advantages, and limitations of different techniques that are currently used for the selection of sperm with intact DNA to be utilized for ICSI. © 2023 EDIZIONI MINERVA MEDICA.
publisher Edizioni Minerva Medica
issn 310808
language English
format Review
accesstype
record_format scopus
collection Scopus
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