Sperm DNA fragmentation test: usefulness in assessing male fertility and assisted reproductive technology outcomes

Sperm DNA fragmentation test: usefulness in assessing male fertility and assisted reproductive technology outcomes

Male infertility is attributed to multiple factors including high levels of sperm DNA fragmentation (SDF). Conventional semen analysis continues to be the gold standard for diagnosis of male factor infertility around the world. However, the limitations of basic semen analysis have prompted the searc...

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Published in:Panminerva Medica
Main Author: Evgeni E.; Sabbaghian M.; Saleh R.; Gül M.; Vogiatzi P.; Durairajanayagam D.; Jindal S.; Parmegiani L.; Boitrelle F.; Colpi G.; Agarwal A.
Format: Review
Language:English
Published: Edizioni Minerva Medica 2023
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85164255480&doi=10.23736%2fS0031-0808.23.04836-X&partnerID=40&md5=9c5cd3252df25319f3412516ee87b98a
id 2-s2.0-85164255480
spelling 2-s2.0-85164255480
Evgeni E.; Sabbaghian M.; Saleh R.; Gül M.; Vogiatzi P.; Durairajanayagam D.; Jindal S.; Parmegiani L.; Boitrelle F.; Colpi G.; Agarwal A.
Sperm DNA fragmentation test: usefulness in assessing male fertility and assisted reproductive technology outcomes
2023
Panminerva Medica
65
2
10.23736/S0031-0808.23.04836-X
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85164255480&doi=10.23736%2fS0031-0808.23.04836-X&partnerID=40&md5=9c5cd3252df25319f3412516ee87b98a
Male infertility is attributed to multiple factors including high levels of sperm DNA fragmentation (SDF). Conventional semen analysis continues to be the gold standard for diagnosis of male factor infertility around the world. However, the limitations of basic semen analysis have prompted the search for complementary assessments of sperm function and integrity. Sperm DNA fragmentation assays (direct or indirect) are emerging as important diagnostic tools in male infertility workups, and have been advocated for use in infertile couples for a variety of reasons. While a controlled degree of DNA nicking is required for appropriate DNA compaction, excessive fragmentation of sperm DNA is linked to impaired male fertility potential, decreased fertilization, poor embryo quality, recurrent pregnancy loss, and failure of assisted reproductive technology procedures. However, there is an ongoing debate regarding whether or not to employ SDF as a routine test for male infertility. This review compiles up-to-date information regarding the pathophysiology of SDF, the currently available SDF tests, and the role of SDF tests in natural and assisted conception conditions. © 2023 EDIZIONI MINERVA MEDICA.
Edizioni Minerva Medica
310808
English
Review
author Evgeni E.; Sabbaghian M.; Saleh R.; Gül M.; Vogiatzi P.; Durairajanayagam D.; Jindal S.; Parmegiani L.; Boitrelle F.; Colpi G.; Agarwal A.
spellingShingle Evgeni E.; Sabbaghian M.; Saleh R.; Gül M.; Vogiatzi P.; Durairajanayagam D.; Jindal S.; Parmegiani L.; Boitrelle F.; Colpi G.; Agarwal A.
Sperm DNA fragmentation test: usefulness in assessing male fertility and assisted reproductive technology outcomes
author_facet Evgeni E.; Sabbaghian M.; Saleh R.; Gül M.; Vogiatzi P.; Durairajanayagam D.; Jindal S.; Parmegiani L.; Boitrelle F.; Colpi G.; Agarwal A.
author_sort Evgeni E.; Sabbaghian M.; Saleh R.; Gül M.; Vogiatzi P.; Durairajanayagam D.; Jindal S.; Parmegiani L.; Boitrelle F.; Colpi G.; Agarwal A.
title Sperm DNA fragmentation test: usefulness in assessing male fertility and assisted reproductive technology outcomes
title_short Sperm DNA fragmentation test: usefulness in assessing male fertility and assisted reproductive technology outcomes
title_full Sperm DNA fragmentation test: usefulness in assessing male fertility and assisted reproductive technology outcomes
title_fullStr Sperm DNA fragmentation test: usefulness in assessing male fertility and assisted reproductive technology outcomes
title_full_unstemmed Sperm DNA fragmentation test: usefulness in assessing male fertility and assisted reproductive technology outcomes
title_sort Sperm DNA fragmentation test: usefulness in assessing male fertility and assisted reproductive technology outcomes
publishDate 2023
container_title Panminerva Medica
container_volume 65
container_issue 2
doi_str_mv 10.23736/S0031-0808.23.04836-X
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85164255480&doi=10.23736%2fS0031-0808.23.04836-X&partnerID=40&md5=9c5cd3252df25319f3412516ee87b98a
description Male infertility is attributed to multiple factors including high levels of sperm DNA fragmentation (SDF). Conventional semen analysis continues to be the gold standard for diagnosis of male factor infertility around the world. However, the limitations of basic semen analysis have prompted the search for complementary assessments of sperm function and integrity. Sperm DNA fragmentation assays (direct or indirect) are emerging as important diagnostic tools in male infertility workups, and have been advocated for use in infertile couples for a variety of reasons. While a controlled degree of DNA nicking is required for appropriate DNA compaction, excessive fragmentation of sperm DNA is linked to impaired male fertility potential, decreased fertilization, poor embryo quality, recurrent pregnancy loss, and failure of assisted reproductive technology procedures. However, there is an ongoing debate regarding whether or not to employ SDF as a routine test for male infertility. This review compiles up-to-date information regarding the pathophysiology of SDF, the currently available SDF tests, and the role of SDF tests in natural and assisted conception conditions. © 2023 EDIZIONI MINERVA MEDICA.
publisher Edizioni Minerva Medica
issn 310808
language English
format Review
accesstype
record_format scopus
collection Scopus
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