Xanthones and 4-Phenylcoumarins from the Twigs of Mesua beccariana (Baill.) Kosterm

• Published in: Natural Product Sciences
• Main Author: Tanjung M.; Tjahjandarie T.S.; Aldin M.F.; Mardhiyyah S.; Maqfiroh I.; Saputri R.D.; Ahmat N.; Sciences N.P.
• Format: Article
• Language: English
• Published: Korean Society of Pharmacognosy 2023
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85163052823&doi=10.20307%2fnps.2023.29.1.38&partnerID=40&md5=851a1f936d61047b30bcaf7362ce6b22

Two xanthones and 4-phenylcoumarins were isolated from the twigs of Mesua beccariana (Baill.) Kosterm. Among them, one new xanthone, beccarianin A (1), along with 7-isoprenyl-jacareubin (2), mammea A/ AA cyclo F (3), and mammea A/BA cyclo F (4). These structures were determined by spectrometric and spectroscopic methods, HRESIMS data, NMR, and UV spectra. Two xanthones (1-2) and two 4-phenyl-coumarins (3-4) were evaluated for their cytotoxic effect on the HeLa cells. Compound 1 showed active activity (IC-Abstract50 = 8.2 µM), and compounds 3-4 showed moderate activity (IC50 = 12.3 and 15.6 µM, respectively). © 2023, Korean Society of Pharmacognosy. All rights reserved.