ELECTROCHEMICAL SENSOR OF MULTIWALLED CARBON NANOTUBE ELECTRODE MODIFIED BY 1-PHENYL-3-METHYL-4-ORTHOFLUORO BENZOYL-5-PYRAZOLONE FOR SENSING DOPAMINE

• Published in: Bulletin of the Chemical Society of Ethiopia
• Main Author: Mahbob E.N.M.; Ahmad M.S.; Isa I.M.; Hashim N.; Ul-Hamid A.; Saidin M.I.; Si S.M.
• Format: Article
• Language: English
• Published: Chemical Society of Ethiopia 2023
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85162014337&doi=10.4314%2fbcse.v37i4.4&partnerID=40&md5=a988d4ec168ddeb3428e54e683294b5b

This work explicates a simple, rapid, and sensitive method for the electrochemical detection of dopamine (DOP) utilising 1-phenyl-3-methyl-4-orthofluorobenzoyl-5-pyrazolone (HPMoFBP)/multiwalled carbon nanotube (MWCNT) carbon paste electrode (CPE). The electrochemical behaviour of DOP was performed through cyclic voltammetry and square wave voltammetry. HPMoFBP/MWCNT showed a higher current at the lower potential for the oxidation of DOP compared to bare MWCNT. The sensor's improved electrocatalytic activity was observed to detect in a 1.0 x 10-1 M phosphate buffer saline (PBS) solution at pH 8.0. A good linear regression analysis was observed between electrical response and the concentration of DOP in the range of 1 to 1000 µM. Under optimized experimental conditions, 1.0 x 10-7 M has been determined as the limit of detection (LOD). The sensor has expressed considerable sensitivity towards DOP detection without interference and is successfully used to determine DOP in dopamine hydrochloride injection. © 2023 Chemical Society of Ethiopia and The Authors.