The Renaissance of Male Infertility Management in the Golden Age of Andrology

The Renaissance of Male Infertility Management in the Golden Age of Andrology

Infertility affects nearly 186 million people worldwide and the male partner is the cause in about half of the cases. Meta-regression data indicate an unexplained decline in sperm concentration and total sperm count over the last four decades, with an increasing prevalence of male infertility. This...

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Published in:World Journal of Men's Health
Main Author: Calogero A.E.; Cannarella R.; Agarwal A.; Hamoda T.A.A.A.M.; Rambhatla A.; Saleh R.; Boitrelle F.; Ziouziou I.; Toprak T.; Gul M.; Avidor-Reiss T.; Kavoussi P.; Chung E.; Birowo P.; Ghayda R.A.; Ko E.; Colpi G.; Dimitriadis F.; Russo G.I.; Martinez M.; Calik G.; Kandil H.; Salvio G.; Mostafa T.; Lin H.; Park H.J.; Gherabi N.; Phuoc N.H.V.; Quang N.; Adriansjah R.; La Vignera S.; Micic S.; Durairajanayagam D.; Serefoglu E.C.; Karthikeyan V.S.; Kothari P.; Atmoko W.; Shah R.
Format: Review
Language:English
Published: Korean Society for Sexual Medicine and Andrology 2023
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85154562574&doi=10.5534%2fwjmh.220213&partnerID=40&md5=c7abee460a951885fa90dd0c6d1290ec
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spelling 2-s2.0-85154562574
Calogero A.E.; Cannarella R.; Agarwal A.; Hamoda T.A.A.A.M.; Rambhatla A.; Saleh R.; Boitrelle F.; Ziouziou I.; Toprak T.; Gul M.; Avidor-Reiss T.; Kavoussi P.; Chung E.; Birowo P.; Ghayda R.A.; Ko E.; Colpi G.; Dimitriadis F.; Russo G.I.; Martinez M.; Calik G.; Kandil H.; Salvio G.; Mostafa T.; Lin H.; Park H.J.; Gherabi N.; Phuoc N.H.V.; Quang N.; Adriansjah R.; La Vignera S.; Micic S.; Durairajanayagam D.; Serefoglu E.C.; Karthikeyan V.S.; Kothari P.; Atmoko W.; Shah R.
The Renaissance of Male Infertility Management in the Golden Age of Andrology
2023
World Journal of Men's Health
41
2
10.5534/wjmh.220213
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85154562574&doi=10.5534%2fwjmh.220213&partnerID=40&md5=c7abee460a951885fa90dd0c6d1290ec
Infertility affects nearly 186 million people worldwide and the male partner is the cause in about half of the cases. Meta-regression data indicate an unexplained decline in sperm concentration and total sperm count over the last four decades, with an increasing prevalence of male infertility. This suggests an urgent need to implement further basic and clinical research in Andrology. Andrology developed as a branch of urology, gynecology, endocrinology, and, dermatology. The first scientific journal devoted to andrological sciences was founded in 1969. Since then, despite great advancements, andrology has encountered several obstacles in its growth. In fact, for cultural reasons, the male partner has often been neglected in the diagnostic and therapeutic workup of the infertile couple. Furthermore, the development of assisted reproductive techniques (ART) has driven a strong impression that this biotechnology can overcome all forms of infertility, with a common belief that having a spermatozoon from a male partner (a sort of sperm donor) is all that is needed to achieve pregnancy. However, clinical practice has shown that the quality of the male gamete is important for a successful ART outcome. Furthermore, the safety of ART has been questioned because of the high prevalence of comorbidities in the offspring of ART conceptions compared to spontaneous conceptions. These issues have paved the way for more research and a greater understanding of the mechanisms of spermatogenesis and male infertility. Consequently, numerous discoveries have been made in the field of andrology, ranging from genetics to several "omics"technologies, oxidative stress and sperm DNA fragmentation, the sixth edition of the WHO manual, artificial intelligence, management of azoospermia, fertility in cancers survivors, artificial testis, 3D printing, gene engineering, stem cells therapy for spermatogenesis, and reconstructive microsurgery and seminal microbiome. Nevertheless, as many cases of male infertility remain idiopathic, further studies are required to improve the clinical management of infertile males. A multidisciplinary strategy involving both clinicians and scientists in basic, translational, and clinical research is the core principle that will allow andrology to overcome its limits and reach further goals. This state-of-the-art article aims to present a historical review of andrology, and, particularly, male infertility, from its "Middle Ages"to its "Renaissance", a golden age of andrology. Copyright © 2023 Korean Society for Sexual Medicine and Andrology.
Korean Society for Sexual Medicine and Andrology
22874208
English
Review
All Open Access; Gold Open Access
author Calogero A.E.; Cannarella R.; Agarwal A.; Hamoda T.A.A.A.M.; Rambhatla A.; Saleh R.; Boitrelle F.; Ziouziou I.; Toprak T.; Gul M.; Avidor-Reiss T.; Kavoussi P.; Chung E.; Birowo P.; Ghayda R.A.; Ko E.; Colpi G.; Dimitriadis F.; Russo G.I.; Martinez M.; Calik G.; Kandil H.; Salvio G.; Mostafa T.; Lin H.; Park H.J.; Gherabi N.; Phuoc N.H.V.; Quang N.; Adriansjah R.; La Vignera S.; Micic S.; Durairajanayagam D.; Serefoglu E.C.; Karthikeyan V.S.; Kothari P.; Atmoko W.; Shah R.
spellingShingle Calogero A.E.; Cannarella R.; Agarwal A.; Hamoda T.A.A.A.M.; Rambhatla A.; Saleh R.; Boitrelle F.; Ziouziou I.; Toprak T.; Gul M.; Avidor-Reiss T.; Kavoussi P.; Chung E.; Birowo P.; Ghayda R.A.; Ko E.; Colpi G.; Dimitriadis F.; Russo G.I.; Martinez M.; Calik G.; Kandil H.; Salvio G.; Mostafa T.; Lin H.; Park H.J.; Gherabi N.; Phuoc N.H.V.; Quang N.; Adriansjah R.; La Vignera S.; Micic S.; Durairajanayagam D.; Serefoglu E.C.; Karthikeyan V.S.; Kothari P.; Atmoko W.; Shah R.
The Renaissance of Male Infertility Management in the Golden Age of Andrology
author_facet Calogero A.E.; Cannarella R.; Agarwal A.; Hamoda T.A.A.A.M.; Rambhatla A.; Saleh R.; Boitrelle F.; Ziouziou I.; Toprak T.; Gul M.; Avidor-Reiss T.; Kavoussi P.; Chung E.; Birowo P.; Ghayda R.A.; Ko E.; Colpi G.; Dimitriadis F.; Russo G.I.; Martinez M.; Calik G.; Kandil H.; Salvio G.; Mostafa T.; Lin H.; Park H.J.; Gherabi N.; Phuoc N.H.V.; Quang N.; Adriansjah R.; La Vignera S.; Micic S.; Durairajanayagam D.; Serefoglu E.C.; Karthikeyan V.S.; Kothari P.; Atmoko W.; Shah R.
author_sort Calogero A.E.; Cannarella R.; Agarwal A.; Hamoda T.A.A.A.M.; Rambhatla A.; Saleh R.; Boitrelle F.; Ziouziou I.; Toprak T.; Gul M.; Avidor-Reiss T.; Kavoussi P.; Chung E.; Birowo P.; Ghayda R.A.; Ko E.; Colpi G.; Dimitriadis F.; Russo G.I.; Martinez M.; Calik G.; Kandil H.; Salvio G.; Mostafa T.; Lin H.; Park H.J.; Gherabi N.; Phuoc N.H.V.; Quang N.; Adriansjah R.; La Vignera S.; Micic S.; Durairajanayagam D.; Serefoglu E.C.; Karthikeyan V.S.; Kothari P.; Atmoko W.; Shah R.
title The Renaissance of Male Infertility Management in the Golden Age of Andrology
title_short The Renaissance of Male Infertility Management in the Golden Age of Andrology
title_full The Renaissance of Male Infertility Management in the Golden Age of Andrology
title_fullStr The Renaissance of Male Infertility Management in the Golden Age of Andrology
title_full_unstemmed The Renaissance of Male Infertility Management in the Golden Age of Andrology
title_sort The Renaissance of Male Infertility Management in the Golden Age of Andrology
publishDate 2023
container_title World Journal of Men's Health
container_volume 41
container_issue 2
doi_str_mv 10.5534/wjmh.220213
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85154562574&doi=10.5534%2fwjmh.220213&partnerID=40&md5=c7abee460a951885fa90dd0c6d1290ec
description Infertility affects nearly 186 million people worldwide and the male partner is the cause in about half of the cases. Meta-regression data indicate an unexplained decline in sperm concentration and total sperm count over the last four decades, with an increasing prevalence of male infertility. This suggests an urgent need to implement further basic and clinical research in Andrology. Andrology developed as a branch of urology, gynecology, endocrinology, and, dermatology. The first scientific journal devoted to andrological sciences was founded in 1969. Since then, despite great advancements, andrology has encountered several obstacles in its growth. In fact, for cultural reasons, the male partner has often been neglected in the diagnostic and therapeutic workup of the infertile couple. Furthermore, the development of assisted reproductive techniques (ART) has driven a strong impression that this biotechnology can overcome all forms of infertility, with a common belief that having a spermatozoon from a male partner (a sort of sperm donor) is all that is needed to achieve pregnancy. However, clinical practice has shown that the quality of the male gamete is important for a successful ART outcome. Furthermore, the safety of ART has been questioned because of the high prevalence of comorbidities in the offspring of ART conceptions compared to spontaneous conceptions. These issues have paved the way for more research and a greater understanding of the mechanisms of spermatogenesis and male infertility. Consequently, numerous discoveries have been made in the field of andrology, ranging from genetics to several "omics"technologies, oxidative stress and sperm DNA fragmentation, the sixth edition of the WHO manual, artificial intelligence, management of azoospermia, fertility in cancers survivors, artificial testis, 3D printing, gene engineering, stem cells therapy for spermatogenesis, and reconstructive microsurgery and seminal microbiome. Nevertheless, as many cases of male infertility remain idiopathic, further studies are required to improve the clinical management of infertile males. A multidisciplinary strategy involving both clinicians and scientists in basic, translational, and clinical research is the core principle that will allow andrology to overcome its limits and reach further goals. This state-of-the-art article aims to present a historical review of andrology, and, particularly, male infertility, from its "Middle Ages"to its "Renaissance", a golden age of andrology. Copyright © 2023 Korean Society for Sexual Medicine and Andrology.
publisher Korean Society for Sexual Medicine and Andrology
issn 22874208
language English
format Review
accesstype All Open Access; Gold Open Access
record_format scopus
collection Scopus
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