Krukenberg tumour as the initial manifestation of lung adenocarcinoma

• Published in: Respirology Case Reports
• Main Author: Lim G.Y.; Wong Y.S.; Tawil Z.; Abdul Kadir R.F.; Ramanathan A.; Natasya Musa A.
• Format: Article
• Language: English
• Published: John Wiley and Sons Inc 2023
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85153783812&doi=10.1002%2frcr2.1133&partnerID=40&md5=a83cc6cc3b0b9b9d57e287c5f3a32660

Krukenberg tumours are unusual metastatic tumours of the ovary with primary tumours from the stomach, breast and gastrointestinal malignancies. Krukenberg tumour from pulmonary malignancy represents an extremely rare situation. This is an elaboration of a case of young women with Krukenberg tumour rising from lung adenocarcinoma. A 38-year-old woman presented with progressive abdominal distention for the past 2-years. Computed tomography (CT) of thorax, abdomen and pelvis revealed a huge ovarian mass with left lung nodules and left-sided pleural effusion. A detailed immunohistochemical staining on pleural fluid cytology confirmed the diagnosis of metastatic adenocarcinoma of lung origin. She underwent doublet platinum chemotherapy as molecular testing for oncogenic mutation was negative. The patient responded well to chemotherapy with a significant reduction in ovarian tumour size. Early identification of the primary source of Krukenberg tumour is paramount to avoid invasive diagnostic surgical intervention for ovarian metastasis. © 2023 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology.