Design of PVA/Chitosan Loaded with Chromolaena Odorata Extract as Wound Dressings

This current study was conducted to investigate the optimal fabrication variable that would give desirable properties in designing hydrogel wound dressings. This new PVA/chitosan hydrogel loaded with Chromolaena odorata were fabricated using solvent-casting method. Variables including PVA concentrat...

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Published in:Journal of Advanced Research in Applied Sciences and Engineering Technology
Main Author: Mokhtar N.A.; Tap F.M.; Khairudin N.B.A.; Ali R.R.; Talib S.Z.A.
Format: Article
Language:English
Published: Penerbit Akademia Baru 2023
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85153533451&doi=10.37934%2faraset.30.1.311320&partnerID=40&md5=d1dcdd8c2f80c88bc2e2b7869536536c
id 2-s2.0-85153533451
spelling 2-s2.0-85153533451
Mokhtar N.A.; Tap F.M.; Khairudin N.B.A.; Ali R.R.; Talib S.Z.A.
Design of PVA/Chitosan Loaded with Chromolaena Odorata Extract as Wound Dressings
2023
Journal of Advanced Research in Applied Sciences and Engineering Technology
30
1
10.37934/araset.30.1.311320
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85153533451&doi=10.37934%2faraset.30.1.311320&partnerID=40&md5=d1dcdd8c2f80c88bc2e2b7869536536c
This current study was conducted to investigate the optimal fabrication variable that would give desirable properties in designing hydrogel wound dressings. This new PVA/chitosan hydrogel loaded with Chromolaena odorata were fabricated using solvent-casting method. Variables including PVA concentration (3, 5, 7 and 10% w/v), chitosan concentration (1, 2, 3, 4 and 5% w/v) and PVA/Chitosan ratio (10:90, 30:70, 50:50, 70:30 and 90:10) were investigated and elucidated. Hydrogel properties including tensile strength, swelling capacity, erosion rate and porosity were measured and effects of the fabrication variables towards these properties were elucidated. In conclusion, desirable PVA/Chitosan hydrogel loaded with Chromolaena odorata extract as wound dressing was favorly designed. The optimal range for PVA concentration, chitosan concentration and PVA/Chitosan ratio were 5% to 7%, 2% to 3% and 50:50 to 70:30 respectively. © 2023, Penerbit Akademia Baru. All rights reserved.
Penerbit Akademia Baru
24621943
English
Article
All Open Access; Hybrid Gold Open Access
author Mokhtar N.A.; Tap F.M.; Khairudin N.B.A.; Ali R.R.; Talib S.Z.A.
spellingShingle Mokhtar N.A.; Tap F.M.; Khairudin N.B.A.; Ali R.R.; Talib S.Z.A.
Design of PVA/Chitosan Loaded with Chromolaena Odorata Extract as Wound Dressings
author_facet Mokhtar N.A.; Tap F.M.; Khairudin N.B.A.; Ali R.R.; Talib S.Z.A.
author_sort Mokhtar N.A.; Tap F.M.; Khairudin N.B.A.; Ali R.R.; Talib S.Z.A.
title Design of PVA/Chitosan Loaded with Chromolaena Odorata Extract as Wound Dressings
title_short Design of PVA/Chitosan Loaded with Chromolaena Odorata Extract as Wound Dressings
title_full Design of PVA/Chitosan Loaded with Chromolaena Odorata Extract as Wound Dressings
title_fullStr Design of PVA/Chitosan Loaded with Chromolaena Odorata Extract as Wound Dressings
title_full_unstemmed Design of PVA/Chitosan Loaded with Chromolaena Odorata Extract as Wound Dressings
title_sort Design of PVA/Chitosan Loaded with Chromolaena Odorata Extract as Wound Dressings
publishDate 2023
container_title Journal of Advanced Research in Applied Sciences and Engineering Technology
container_volume 30
container_issue 1
doi_str_mv 10.37934/araset.30.1.311320
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85153533451&doi=10.37934%2faraset.30.1.311320&partnerID=40&md5=d1dcdd8c2f80c88bc2e2b7869536536c
description This current study was conducted to investigate the optimal fabrication variable that would give desirable properties in designing hydrogel wound dressings. This new PVA/chitosan hydrogel loaded with Chromolaena odorata were fabricated using solvent-casting method. Variables including PVA concentration (3, 5, 7 and 10% w/v), chitosan concentration (1, 2, 3, 4 and 5% w/v) and PVA/Chitosan ratio (10:90, 30:70, 50:50, 70:30 and 90:10) were investigated and elucidated. Hydrogel properties including tensile strength, swelling capacity, erosion rate and porosity were measured and effects of the fabrication variables towards these properties were elucidated. In conclusion, desirable PVA/Chitosan hydrogel loaded with Chromolaena odorata extract as wound dressing was favorly designed. The optimal range for PVA concentration, chitosan concentration and PVA/Chitosan ratio were 5% to 7%, 2% to 3% and 50:50 to 70:30 respectively. © 2023, Penerbit Akademia Baru. All rights reserved.
publisher Penerbit Akademia Baru
issn 24621943
language English
format Article
accesstype All Open Access; Hybrid Gold Open Access
record_format scopus
collection Scopus
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