Design of PVA/Chitosan Loaded with Chromolaena Odorata Extract as Wound Dressings

• Published in: Journal of Advanced Research in Applied Sciences and Engineering Technology
• Main Author: Mokhtar N.A.; Tap F.M.; Khairudin N.B.A.; Ali R.R.; Talib S.Z.A.
• Format: Article
• Language: English
• Published: Penerbit Akademia Baru 2023
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85153533451&doi=10.37934%2faraset.30.1.311320&partnerID=40&md5=d1dcdd8c2f80c88bc2e2b7869536536c

This current study was conducted to investigate the optimal fabrication variable that would give desirable properties in designing hydrogel wound dressings. This new PVA/chitosan hydrogel loaded with Chromolaena odorata were fabricated using solvent-casting method. Variables including PVA concentration (3, 5, 7 and 10% w/v), chitosan concentration (1, 2, 3, 4 and 5% w/v) and PVA/Chitosan ratio (10:90, 30:70, 50:50, 70:30 and 90:10) were investigated and elucidated. Hydrogel properties including tensile strength, swelling capacity, erosion rate and porosity were measured and effects of the fabrication variables towards these properties were elucidated. In conclusion, desirable PVA/Chitosan hydrogel loaded with Chromolaena odorata extract as wound dressing was favorly designed. The optimal range for PVA concentration, chitosan concentration and PVA/Chitosan ratio were 5% to 7%, 2% to 3% and 50:50 to 70:30 respectively. © 2023, Penerbit Akademia Baru. All rights reserved.