Synthesis, biological evaluation and molecular docking study of oxindole based chalcone analogues as potent anti-Alzheimer agents

QR Code

Synthesis, biological evaluation and molecular docking study of oxindole based chalcone analogues as potent anti-Alzheimer agents

With the goal of developing potential cholinesterase pharmaco-therapeutics, a new class of thirty analogs oxindole-based chalcone were synthesized by reacting nitro substituted oxindole with various substituted benzaldehyde in the presence of a base in ethanol under reflux conditions. All the synthe...

Full description

Bibliographic Details
Published in:	Journal of Molecular Structure
Main Author:	Taha M.; Sadia H.; Rahim F.; Khan M.I.; Hayat S.; Iqbal N.; Nawaz F.; Ullah H.; Zada H.; Shah S.A.A.; Wadood A.; Farooq R.K.; Khan K.M.
Format:	Article
Language:	English
Published:	Elsevier B.V. 2023
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85152600286&doi=10.1016%2fj.molstruc.2023.135530&partnerID=40&md5=471b7a496d0725f1ce4e7a9adee116f9

Similar Items

Oxindole-based chalcones: synthesis and their activity against glycation of proteins
by: Khan A.; Khan A.; Farooq U.; Taha M.; Shah S.A.A.; Halim S.A.; Akram A.; Khan M.Z.; Jan A.K.; Al-Harrasi A.
Published: (2019)

Synthesis, in vitro biological screening and docking study of benzo[d]oxazole bis Schiff base derivatives as a potent anti-Alzheimer agent
by: Taha M.; Rahim F.; Zaman K.; Anouar E.H.; Uddin N.; Nawaz F.; Sajid M.; Khan K.M.; Shah A.A.; Wadood A.; Rehman A.U.; Alhibshi A.H.
Published: (2023)

Synthesis, biological evaluation and molecular docking study of indazole based schiff base analogues as new anti-diabetic inhibitors
by: Taha, et al.
Published: (2024)

Synthesis, in vitro α-glucosidase activity and in silico molecular docking study of isatin analogues
by: Ullah H.; Rahim F.; Ullah E.; Hayat S.; Zada H.; Khan F.; Wadood A.; Nawaz F.; Rehman Z.U.; Shah S.A.A.
Published: (2023)

Synthesis, In Vitro Biological Evaluation and Molecular Modeling of Benzimidazole-Based Pyrrole/Piperidine Hybrids Derivatives as Potential Anti-Alzheimer Agents
by: Tariq, et al.
Published: (2024)

Synthesis, biological and computational evaluation of benzoxazole hybrid analogs as potential anti-Alzheimer's agents
by: Othman M.S.; Hussain R.; Rahim F.; Ullah H.; Khan S.; Taha M.; Fareid M.A.; Altaleb A.T.; Aboelnaga S.M.; Shah S.A.A.
Published: (2024)

Synthesis, biological evaluation and molecular docking study of indazole based schiff base analogues as new anti-diabetic inhibitors
by: Taha M.; Gilani S.J.; Kazmi I.; Rahim F.; Adalat B.; Ullah H.; Nawaz F.; Wadood A.; Ali Z.; Shah S.A.A.; Khan K.M.
Published: (2024)

Synthesis, biological evaluation, molecular docking and dynamic simulation of novel benzofuran derivatives as potential agents against Alzheimer's disease
by: Nadeem, et al.
Published: (2025)

New benzimidazole based Schiff bases as potent anti-alzheimer agents: Synthesis, bio-evaluation and molecular docking study
by: Othman M.S.; Hayat S.; Rahim F.; Taha M.; Sajid M.; Khan S.; Iqbal W.; Shah S.A.A.; Fareid M.A.; Aboelnaga S.M.; Abdel-Hafez L.J.; Hafez M.M.
Published: (2024)

Synthesis, biological evaluation, molecular docking and dynamic simulation of novel benzofuran derivatives as potential agents against Alzheimer's disease
by: Nadeem M.S.; Hayat S.; Rahim F.; Khan J.A.; Ullah H.; Taha M.; Gupta G.; Wadood A.; Shah S.A.A.; Kazmi I.; Iftikhar S.; Muhammad K.
Published: (2025)

Synthesis of 4-thiazolidinone analogs as potent in vitro anti-urease agents
by: Rahim F.; Zaman K.; Ullah H.; Taha M.; Wadood A.; Javed M.T.; Rehman W.; Ashraf M.; Uddin R.; Uddin I.; Asghar H.; Khan A.A.; Khan K.M.
Published: (2015)

Synthesis, In Vitro Biological Evaluation and Molecular Modeling of Benzimidazole-Based Pyrrole/Piperidine Hybrids Derivatives as Potential Anti-Alzheimer Agents
by: Tariq S.; Rahim F.; Ullah H.; Sarfraz M.; Hussain R.; Khan S.; Khan M.U.; Rehman W.; Hussain A.; Bhat M.A.; Farooqi M.K.; Shah S.A.A.; Iqbal N.
Published: (2024)

Biologically Potent Benzimidazole-Based-Substituted Benzaldehyde Derivatives as Potent Inhibitors for Alzheimer’s Disease along with Molecular Docking Study
by: Adalat B.; Rahim F.; Rehman W.; Ali Z.; Rasheed L.; Khan Y.; Farghaly T.A.; Shams S.; Taha M.; Wadood A.; Shah S.A.A.; Abdellatif M.H.
Published: (2023)

Synthesis, in vitro urease inhibitory potential and molecular docking study of benzofuran-based-thiazoldinone analogues
by: Taha M.; Rahim F.; Ullah H.; Wadood A.; Farooq R.K.; Shah S.A.A.; Nawaz M.; Zakaria Z.A.
Published: (2020)

Synthesis, DFT Studies, Molecular Docking and Biological Activity Evaluation of Thiazole-Sulfonamide Derivatives as Potent Alzheimer’s Inhibitors
by: Khan S.; Ullah H.; Taha M.; Rahim F.; Sarfraz M.; Iqbal R.; Iqbal N.; Hussain R.; Ali Shah S.A.; Ayub K.; Albalawi M.A.; Abdelaziz M.A.; Alatawi F.S.; Khan K.M.
Published: (2023)

Molecular modeling and synthesis of novel benzimidazole-derived thiazolidinone bearing chalcone derivatives: A promising approach to develop potential anti-diabetic agents
by: Abbasi S.A.; Rehman W.; Rahim F.; Hussain R.; Hawsawi M.B.; Alluhaibi M.S.; Alharbi M.; Taha M.; Khan S.; Rasheed L.; Wadood A.; Ali Shah S.A.
Published: (2024)

Molecular modeling and synthesis of novel benzimidazole-derived thiazolidinone bearing chalcone derivatives: a promising approach to develop potential anti-diabetic agents
by: Abbasi, et al.
Published: (2024)

Oxindole based oxadiazole hybrid analogs: Novel α-glucosidase inhibitors
by: Taha M.; Imran S.; Rahim F.; Wadood A.; Khan K.M.
Published: (2018)

Synthesis, biological evaluation and molecular docking study of benzimidazole derivatives as α-glucosidase inhibitors and anti-diabetes candidates
by: Hayat S.; Ullah H.; Rahim F.; Ullah I.; Taha M.; Iqbal N.; Khan F.; Khan M.S.; Shah S.A.A.; Wadood A.; Sajid M.; Abdalla A.N.
Published: (2023)

Investigation of novel benzimidazole-based indole/thiazole hybrids derivatives as effective anti-diabetics and anti-alzheimer's agents: Structure-activity relationship insight, in vitro and in silico approaches
by: Naz H.; Othman M.S.; Rahim F.; Hussain R.; Khan S.; Taha M.; Hafez M.M.; Abdel-Hafez L.J.; Ullah H.; Khan I.U.; Khan Y.; Shah S.A.A.
Published: (2024)

Molecular docking, synthesis and biological significance of pyrimidine analogues as prospective antimicrobial and antiproliferative agents
by: Kumar S.; Kaushik A.; Narasimhan B.; Shah S.A.A.; Lim S.M.; Ramasamy K.; Mani V.
Published: (2019)

Design, synthesis and biological profile of heterocyclic benzimidazole analogues as prospective antimicrobial and antiproliferative agents
by: Tahlan S.; Kumar S.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Pathania R.; Narasimhan B.
Published: (2019)

A multi-component reaction approach to the synthesis of potent antidiabetic agents five-membered iminosugars analogues
by: Wibowo A.; Shaameri Z.; Mohammat M.F.; Hamzah A.S.
Published: (2020)

Triazinoindole analogs as potent inhibitors of α-glucosidase: Synthesis, biological evaluation and molecular docking studies
by: Rahim F.; Ullah K.; Ullah H.; Wadood A.; Taha M.; Rehman A.U.; Uddin I.; Ashraf M.; Shaukat A.; Rehman W.; Hussain S.; Khan K.M.
Published: (2015)

Design and synthesis of chalcone derivatives as potent tyrosinase inhibitors and their structural activity relationship
by: Akhtar M.N.; Sakeh N.M.; Zareen S.; Gul S.; Lo K.M.; Ul-Haq Z.; Shah S.A.A.; Ahmad S.
Published: (2015)

Synthesis, in vitro urease inhibitory potential and molecular docking study of Benzimidazole analogues
by: Zaman K.; Rahim F.; Taha M.; Ullah H.; Wadood A.; Nawaz M.; Khan F.; Wahab Z.; Shah S.A.A.; Rehman A.U.; Kawde A.-N.; Gollapalli M.
Published: (2019)

Synthesis of novel derivatives of oxindole, their urease inhibition and molecular docking studies
by: Taha M.; Ismail N.H.; Khan A.; Shah S.A.A.; Anwar A.; Halim S.A.; Fatmi M.Q.; Imran S.; Rahim F.; Khan K.M.
Published: (2015)

Synthesis, SAR elucidations and molecular docking study of newly designed isatin based oxadiazole analogs as potent inhibitors of thymidine phosphorylase
by: Javid M.T.; Rahim F.; Taha M.; Nawaz M.; Wadood A.; Ali M.; Mosaddik A.; Shah S.A.A.; Farooq R.K.
Published: (2018)

The β-carboline analogs as a potent inhibitor for Alzheimer's Disease, molecular docking and dynamics simulation study
by: Taha M.; Rahim F.; Khan A.A.; Adalat B.; Imran S.; Alshehri J.M.; Ahmad A.; Khan K.M.; Shah S.A.A.; Uddin N.
Published: (2023)

Synthetic N-aralkylated-N-(2,4-dimethylphenyl)benzenesulfonamides: As potent anti-bacterial agents
by: Siddiqui S.Z.; Sarwar A.; Abbasi M.A.; Aziz-Ur-Rehman; Hussain M.; Irshad M.; Shah S.A.A.
Published: (2016)

Synthesis and Molecular Docking of New Bis-Thiazolidinone-Based Chalcone Analogs as Effective Inhibitors of Acetylcholinesterase and Butyrylcholinesterase
by: Hussain R.; Rahim F.; Rehman W.; Taha M.; Khan S.; Zaman K.; Adnan Ali Shah S.; Wadood A.; Imran S.; Abdellatif M.H.
Published: (2022)

Synthesis, molecular docking study and in vitro thymidine phosphorylase inhibitory potential of oxadiazole derivatives
by: Ullah H.; Rahim F.; Taha M.; Uddin I.; Wadood A.; Shah S.A.A.; Farooq R.K.; Nawaz M.; Wahab Z.; Khan K.M.
Published: (2018)

New biologically dynamic hybrid pharmacophore triazinoindole-based-thiadiazole as potent α-glucosidase inhibitors: In vitro and in silico study
by: Khan A.A.; Rahim F.; Taha M.; Rehman W.; Iqbal N.; Wadood A.; Ahmad N.; Shah S.A.A.; Ghoneim M.M.; Alshehri S.; Salahuddin M.; Khan K.M.
Published: (2022)

Synthesis of New Triazole-Based Thiosemicarbazone Derivatives as Anti-Alzheimer’s Disease Candidates: Evidence-Based In Vitro Study
by: Rahim F.; Ullah H.; Taha M.; Hussain R.; Sarfraz M.; Iqbal R.; Iqbal N.; Khan S.; Ali Shah S.A.; Albalawi M.A.; Abdelaziz M.A.; Alatawi F.S.; Alasmari A.; Sakran M.I.; Zidan N.; Jafri I.; Khan K.M.
Published: (2023)

Synthesis, in vitro antiurease, in vivo antinematodal activity of quinoline analogs and their in-silico study
by: Zaman K.; Rahim F.; Taha M.; Sajid M.; Hayat S.; Nawaz M.; Salahuddin M.; Iqbal N.; Khan N.U.; Shah S.A.A.; Farooq R.K.; Bahadar A.; Wadood A.; Khan K.M.
Published: (2021)

Synthesis, molecular docking, acetylcholinesterase and butyrylcholinesterase inhibitory potential of thiazole analogs as new inhibitors for Alzheimer disease
by: Rahim F.; Javed M.T.; Ullah H.; Wadood A.; Taha M.; Ashraf M.; Qurat-Ul-Ain; Khan M.A.; Khan F.; Mirza S.; Khan K.M.
Published: (2015)

Multipotent Cholinesterase Inhibitors for the Treatment of Alzheimer’s Disease: Synthesis, Biological Analysis and Molecular Docking Study of Benzimidazole-Based Thiazole Derivatives
by: Hussain R.; Ullah H.; Rahim F.; Sarfraz M.; Taha M.; Iqbal R.; Rehman W.; Khan S.; Shah S.A.A.; Hyder S.; Alhomrani M.; Alamri A.S.; Abdulaziz O.; Abdelaziz M.A.
Published: (2022)

Synthesis of Indole Based Sulfonamide Derivatives as potent inhibitors of α-glucosidase and α-amylase in management of type-II diabetes
by: Ullah W.; Rahim F.; Hayat S.; Ullah H.; Taha M.; Khan S.; Khaliq A.; Bibi S.; Gohar O.; Iqbal N.; Shah S.A.A.; Khan K.M.
Published: (2024)

New triazinoindole bearing thiazole/oxazole analogues: Synthesis, α-amylase inhibitory potential and molecular docking study
by: Rahim F.; Tariq S.; Taha M.; Ullah H.; Zaman K.; Uddin I.; Wadood A.; Khan A.A.; Rehman A.U.; Uddin N.; Zafar S.; Shah S.A.A.
Published: (2019)

Synthesis of symmetrical bis-Schiff base-disulfide hybrids as highly effective anti-leishmanial agents
by: Taha M.; Sain A.A.; Ali M.; Anouar E.H.; Rahim F.; Ismail N.H.; Adenan M.I.; Imran S.; Al-Harrasi A.; Nawaz F.; Iqbal N.; Khan K.M.
Published: (2020)