Synthesis of New Triazole-Based Thiosemicarbazone Derivatives as Anti-Alzheimer’s Disease Candidates: Evidence-Based In Vitro Study
Triazole-based thiosemicarbazone derivatives (6a–u) were synthesized then characterized by spectroscopic techniques, such as 1HNMR and 13CNMR and HRMS (ESI). Newly synthesized derivatives were screened in vitro for inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (Bu...
出版年: | Molecules |
---|---|
主要な著者: | Rahim F., Ullah H., Taha M., Hussain R., Sarfraz M., Iqbal R., Iqbal N., Khan S., Ali Shah S.A., Albalawi M.A., Abdelaziz M.A., Alatawi F.S., Alasmari A., Sakran M.I., Zidan N., Jafri I., Khan K.M. |
フォーマット: | 論文 |
言語: | English |
出版事項: |
MDPI
2023
|
オンライン・アクセス: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85145734882&doi=10.3390%2fmolecules28010021&partnerID=40&md5=4b873fd689098bf0a7d7cc390025af4e |
類似資料
-
Synthesis, DFT Studies, Molecular Docking and Biological Activity Evaluation of Thiazole-Sulfonamide Derivatives as Potent Alzheimer’s Inhibitors
著者:: Khan S., 等
出版事項: (2023) -
New benzimidazole based Schiff bases as potent anti-alzheimer agents: Synthesis, bio-evaluation and molecular docking study
著者:: Othman M.S.; Hayat S.; Rahim F.; Taha M.; Sajid M.; Khan S.; Iqbal W.; Shah S.A.A.; Fareid M.A.; Aboelnaga S.M.; Abdel-Hafez L.J.; Hafez M.M.
出版事項: (2024) -
2-Furoic piperazide derivatives as promising drug candidates of type 2 diabetes and Alzheimer's diseases: In vitro and in silico studies
著者:: Abbasi M.A.; Hassan M.; ur-Rehman A.; Siddiqui S.Z.; Hussain G.; Shah S.A.A.; Ashraf M.; Shahid M.; Seo S.Y.
出版事項: (2018) -
Microwave-assisted synthesis of triazole derivatives conjugated with piperidine as new anti-enzymatic agents
著者:: Virk N.A.; Rehman A.-U.; Abbasi M.A.; Siddiqui S.Z.; Iqbal J.; Rasool S.; Khan S.U.; Htar T.T.; Khalid H.; Laulloo S.J.; Ali Shah S.A.
出版事項: (2020) -
Design, synthesis of triazole-based scaffolds, N-(substitutedphenyl)-2-(5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-ylthiol)acetamides: As potential anti-cholinesterase agents for neurodegenerative diseases
著者:: Siddiqui S.Z.; Arfan M.; Abbasi M.A.; Aziz-ur-Rehman; Shah S.A.A.; Parveen R.; Ashraf M.; Solangi M.; Hussain S.; Khan K.M.
出版事項: (2023)