Synthesis of New Triazole-Based Thiosemicarbazone Derivatives as Anti-Alzheimer’s Disease Candidates: Evidence-Based In Vitro Study

QR Code

Synthesis of New Triazole-Based Thiosemicarbazone Derivatives as Anti-Alzheimer’s Disease Candidates: Evidence-Based In Vitro Study

Triazole-based thiosemicarbazone derivatives (6a–u) were synthesized then characterized by spectroscopic techniques, such as 1HNMR and 13CNMR and HRMS (ESI). Newly synthesized derivatives were screened in vitro for inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (Bu...

Full description

Bibliographic Details
Published in:	Molecules
Main Author:	Rahim F.; Ullah H.; Taha M.; Hussain R.; Sarfraz M.; Iqbal R.; Iqbal N.; Khan S.; Ali Shah S.A.; Albalawi M.A.; Abdelaziz M.A.; Alatawi F.S.; Alasmari A.; Sakran M.I.; Zidan N.; Jafri I.; Khan K.M.
Format:	Article
Language:	English
Published:	MDPI 2023
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85145734882&doi=10.3390%2fmolecules28010021&partnerID=40&md5=4b873fd689098bf0a7d7cc390025af4e

Similar Items

Synthesis, DFT Studies, Molecular Docking and Biological Activity Evaluation of Thiazole-Sulfonamide Derivatives as Potent Alzheimer’s Inhibitors
by: Khan S.; Ullah H.; Taha M.; Rahim F.; Sarfraz M.; Iqbal R.; Iqbal N.; Hussain R.; Ali Shah S.A.; Ayub K.; Albalawi M.A.; Abdelaziz M.A.; Alatawi F.S.; Khan K.M.
Published: (2023)

Benzimidazole Bearing Thiosemicarbazone Derivatives Act as Potent α-Amylase and α-Glucosidase Inhibitors; Synthesis, Bioactivity Screening and Molecular Docking Study
by: Ullah H.; Khan S.; Rahim F.; Taha M.; Iqbal R.; Sarfraz M.; Shah S.A.A.; Sajid M.; Awad M.F.; Omran A.; Albalawi M.A.; Abdelaziz M.A.; Al Areefy A.; Jafri I.
Published: (2022)

Multipotent Cholinesterase Inhibitors for the Treatment of Alzheimer’s Disease: Synthesis, Biological Analysis and Molecular Docking Study of Benzimidazole-Based Thiazole Derivatives
by: Hussain R.; Ullah H.; Rahim F.; Sarfraz M.; Taha M.; Iqbal R.; Rehman W.; Khan S.; Shah S.A.A.; Hyder S.; Alhomrani M.; Alamri A.S.; Abdulaziz O.; Abdelaziz M.A.
Published: (2022)

Synthesis, In Vitro Biological Evaluation and Molecular Modeling of Benzimidazole-Based Pyrrole/Piperidine Hybrids Derivatives as Potential Anti-Alzheimer Agents
by: Tariq S.; Rahim F.; Ullah H.; Sarfraz M.; Hussain R.; Khan S.; Khan M.U.; Rehman W.; Hussain A.; Bhat M.A.; Farooqi M.K.; Shah S.A.A.; Iqbal N.
Published: (2024)

Synthesis, In Vitro Biological Evaluation and Molecular Modeling of Benzimidazole-Based Pyrrole/Piperidine Hybrids Derivatives as Potential Anti-Alzheimer Agents
by: Tariq, et al.
Published: (2024)

Synthesis, biological evaluation and molecular docking study of benzimidazole derivatives as α-glucosidase inhibitors and anti-diabetes candidates
by: Hayat S.; Ullah H.; Rahim F.; Ullah I.; Taha M.; Iqbal N.; Khan F.; Khan M.S.; Shah S.A.A.; Wadood A.; Sajid M.; Abdalla A.N.
Published: (2023)

Synthesis, biological evaluation and molecular docking study of oxindole based chalcone analogues as potent anti-Alzheimer agents
by: Taha M.; Sadia H.; Rahim F.; Khan M.I.; Hayat S.; Iqbal N.; Nawaz F.; Ullah H.; Zada H.; Shah S.A.A.; Wadood A.; Farooq R.K.; Khan K.M.
Published: (2023)

New Cholinesterase inhibitors based on 1,2,4-triazole bearing benzenesulfonohydrazide skeleton: Synthesis, in vitro and in silico studies
by: Othman M.S.; Naz H.; Rahim F.; Ullah H.; Hussain R.; Taha M.; Khan S.; Fareid M.A.; Aboelnaga S.M.; Altaleb A.T.; Iqbal R.; Adnan Ali Shah S.
Published: (2024)

New benzimidazole based Schiff bases as potent anti-alzheimer agents: Synthesis, bio-evaluation and molecular docking study
by: Othman M.S.; Hayat S.; Rahim F.; Taha M.; Sajid M.; Khan S.; Iqbal W.; Shah S.A.A.; Fareid M.A.; Aboelnaga S.M.; Abdel-Hafez L.J.; Hafez M.M.
Published: (2024)

Microwave-assisted synthesis of triazole derivatives conjugated with piperidine as new anti-enzymatic agents
by: Virk N.A.; Rehman A.-U.; Abbasi M.A.; Siddiqui S.Z.; Iqbal J.; Rasool S.; Khan S.U.; Htar T.T.; Khalid H.; Laulloo S.J.; Ali Shah S.A.
Published: (2020)

2-Furoic piperazide derivatives as promising drug candidates of type 2 diabetes and Alzheimer's diseases: In vitro and in silico studies
by: Abbasi M.A.; Hassan M.; ur-Rehman A.; Siddiqui S.Z.; Hussain G.; Shah S.A.A.; Ashraf M.; Shahid M.; Seo S.Y.
Published: (2018)

Investigation of novel benzimidazole-based indole/thiazole hybrids derivatives as effective anti-diabetics and anti-alzheimer's agents: Structure-activity relationship insight, in vitro and in silico approaches
by: Naz H.; Othman M.S.; Rahim F.; Hussain R.; Khan S.; Taha M.; Hafez M.M.; Abdel-Hafez L.J.; Ullah H.; Khan I.U.; Khan Y.; Shah S.A.A.
Published: (2024)

Synthesis of modified Schiff base appended 1,2,4-triazole hybrids scaffolds: Elucidating the in vitro and in silico α-amylase and α-glucosidase inhibitors potential
by: Abbasi S.A.; Rahim F.; Hussain R.; Rehman W.; Khan S.; Taha M.; Iqbal T.; Khan Y.; Ali Shah S.A.
Published: (2024)

Synthesis, biological and computational evaluation of benzoxazole hybrid analogs as potential anti-Alzheimer's agents
by: Othman M.S.; Hussain R.; Rahim F.; Ullah H.; Khan S.; Taha M.; Fareid M.A.; Altaleb A.T.; Aboelnaga S.M.; Shah S.A.A.
Published: (2024)

Synthesis of modified Schiff base appended 1,2,4-triazole hybrids scaffolds: elucidating the in vitro and in silico α-amylase and α-glucosidase inhibitors potential
by: Abbasi, et al.
Published: (2024)

Design, synthesis of triazole-based scaffolds, N-(substitutedphenyl)-2-(5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-ylthiol)acetamides: As potential anti-cholinesterase agents for neurodegenerative diseases
by: Siddiqui S.Z.; Arfan M.; Abbasi M.A.; Aziz-ur-Rehman; Shah S.A.A.; Parveen R.; Ashraf M.; Solangi M.; Hussain S.; Khan K.M.
Published: (2023)

(1E)-1-(2-pyrazinyl)ethanone thiosemicarbazone (PT) as a tyrosinase inhibitor with anti-browning activity: Spectroscopy, DFT and molecular docking studies
by: Shamsuri S.S.; Normaya E.; Ismail H.; Iqbal A.; Piah M.B.M.; Farina Y.; Hamzah A.S.; Ahmad M.N.
Published: (2023)

Novel 1,2,4-triazoles as anti-enzymatic agents: Microwave versus conventional synthesis, characterization, docking and BSA binding studies
by: Akhtar Virk N.; Rehman A.U.; Shuaib A.; Iqbal J.; Rasool S.; Al-Mijalli S.H.; Abid M.A.; Nisa M.-U.; Ali Shah S.A.; Saadiq M.
Published: (2023)

Synthesis, molecular docking, acetylcholinesterase and butyrylcholinesterase inhibitory potential of thiazole analogs as new inhibitors for Alzheimer disease
by: Rahim F.; Javed M.T.; Ullah H.; Wadood A.; Taha M.; Ashraf M.; Qurat-Ul-Ain; Khan M.A.; Khan F.; Mirza S.; Khan K.M.
Published: (2015)

Semicarbazones, thiosemicarbazone, thiazole and oxazole analogues as monoamine oxidase inhibitors: Synthesis, characterization, biological evaluation, molecular docking, and kinetic studies
by: Qazi S.U.; Naz A.; Hameed A.; Osra F.A.; Jalil S.; Iqbal J.; Shah S.A.A.; Mirza A.Z.
Published: (2021)

Synthesis of modified 1,3,4-thiadiazole incorporating substituted thiosemicarbazide derivatives: Elucidating the in vitro and in silico studies to develop promising anti-diabetic agent
by: Abbasi S.A.; Rahim F.; Hussain R.; Khan S.; Ullah H.; Iqbal T.; Iqbal N.; Khan H.U.; Khan S.; Iqbal R.; Shah S.A.A.; Al Obaid S.; Ansari M.J.
Published: (2024)

Synthesis of benzimidazole–based analogs as anti alzheimer’s disease compounds and their molecular docking studies
by: Adalat B.; Rahim F.; Taha M.; Alshamrani F.J.; Anouar E.H.; Uddin N.; Shah S.A.A.; Ali Z.; Zakaria Z.A.
Published: (2020)

Synthesis of Benzofuran–based Schiff bases as anti-diabetic compounds and their molecular docking studies
by: Adalat B.; Rahim F.; Taha M.; Hayat S.; Iqbal N.; Ali Z.; Shah S.A.A.; Wadood A.; Rehman A.U.; Khan K.M.
Published: (2022)

Mass spectrometry-based immunopeptidomics and computational vaccinology strategies for the identification of universal Shigella immunogenic candidates
by: Mohammad Shabani N.R.; Khairul Hisyam Ismail C.M.; Anthony A.A.; Leow C.H.; Chuah C.; Abdul Majeed A.B.; Nor N.M.; He Y.; Banga Singh K.K.; Leow C.Y.
Published: (2022)

Synthesis, in vitro biological screening and docking study of benzo[d]oxazole bis Schiff base derivatives as a potent anti-Alzheimer agent
by: Taha M.; Rahim F.; Zaman K.; Anouar E.H.; Uddin N.; Nawaz F.; Sajid M.; Khan K.M.; Shah A.A.; Wadood A.; Rehman A.U.; Alhibshi A.H.
Published: (2023)

Synthesis of Indole Based Sulfonamide Derivatives as potent inhibitors of α-glucosidase and α-amylase in management of type-II diabetes
by: Ullah W.; Rahim F.; Hayat S.; Ullah H.; Taha M.; Khan S.; Khaliq A.; Bibi S.; Gohar O.; Iqbal N.; Shah S.A.A.; Khan K.M.
Published: (2024)

Bio-Oriented Synthesis and Molecular Docking Studies of 1,2,4-Triazole Based Derivatives as Potential Anti-Cancer Agents against HepG2 Cell Line
by: Akhter N.; Batool S.; Khan S.G.; Rasool N.; Anjum F.; Rasul A.; Adem Ş.; Mahmood S.; Rehman A.U.; Nisa M.U.; Razzaq Z.; Christensen J.B.; Abourehab M.A.S.; Shah S.A.A.; Imran S.
Published: (2023)

In vitro and in silico assessment of bioactivity properties and pharmacokinetic studies of new 3,5-disubstituted-1,2,4-triazoles
by: Amjad H.; Abbasi M.A.; Siddiqui S.Z.; Iqbal J.; Rasool S.; Ashraf M.; Hussain S.; Shah S.A.A.; Imran S.; Shahid M.; Rasool A.; Rehman M.T.; Rehman A.U.
Published: (2023)

BSA Binding, molecular docking and in vitro biological screening of some new 1, 2, 4-triazole heterocycles bearing azinane nucleus
by: Iqbal J.; Aziz-Ur-Rehman; Abbasi M.A.; Siddiqui S.Z.; Khalid H.; Laulloo S.J.; Chohan T.A.; Rasool S.; Ali Shah S.A.
Published: (2020)

Synthesis of acetamide derivatives of 1,2,4-triazole bearing azinane and their binding interactions with bovine serum albumin using spectroscopic techniques
by: Iqbal J.; Ur-Rehman A.; Abbasi M.A.; Siddiqui S.Z.; Khalid H.; Laulloo S.J.; Joondan N.; Taupass A.B.; Rasool S.; Shah S.A.A.
Published: (2018)

Synthesis, β-Glucuronidase Inhibition, and Molecular Docking Studies of 1,2,4-Triazole Hydrazones
by: Jamil W.; Kumari D.; Taha M.; Khan M.N.; Baharudin M.S.; Ali M.; Kanwal M.; Lashari M.S.; Khan K.M.
Published: (2018)

Synthesis and biological evaluation of substituted benzohydrazide Schiff base adduct as potential cholinesterase inhibitors
by: Zulfiqar, et al.
Published: (2024)

Synthesis, In Vitro Enzymatic Inhibition, and Molecular Modeling of Novel Piperazine-Based Bis-Schiff Base Derivatives as Promising Anti-urease Agents
by: Masood N.; Hussain R.; Khan S.; Rahim F.; Mumtaz S.; Taha M.; Ur Rahman Abid O.; Iqbal T.; Adnan Ali Shah S.; Omar Al Wesabi E.; Magam S.M.
Published: (2024)

Conventional versus microwave assisted synthesis, molecular docking and enzyme inhibitory activities of new 3,4,5-trisubstituted-1,2,4-triazole analogues
by: Virk N.A.; Rehman A.; Abbasi M.A.; Siddiqui S.Z.; Rashid U.; Iqbal J.; Saleem M.; Ashraf M.; Shahid W.; Shah S.A.A.
Published: (2018)

Synthesis and Nucleotide Pyrophosphatase/Phosphodiesterase Inhibition Studies of Carbohydrazides Based on Benzimidazole-Benzothiazine Skeleton
by: Kanwal A.; Ullah S.; Ahmad M.; Pelletier J.; Aslam S.; Sultan S.; Sévigny J.; Iqbal M.; Iqbal J.
Published: (2020)

Synthesis and biological evaluation of substituted benzohydrazide Schiff base adduct as potential cholinesterase inhibitors
by: Zulfiqar A.; Khan I.U.; Nabi M.; Ullah H.; Iqbal N.; Zeb B.; Hussain A.; Khan D.; Rab A.; Junaid S.M.; Taha M.; Shah S.A.A.; Rahim F.
Published: (2024)

Biologically Potent Benzimidazole-Based-Substituted Benzaldehyde Derivatives as Potent Inhibitors for Alzheimer’s Disease along with Molecular Docking Study
by: Adalat B.; Rahim F.; Rehman W.; Ali Z.; Rasheed L.; Khan Y.; Farghaly T.A.; Shams S.; Taha M.; Wadood A.; Shah S.A.A.; Abdellatif M.H.
Published: (2023)

Synthesis, In Vitro Enzymatic Inhibition, and Molecular Modeling of Novel Piperazine-Based Bis-Schiff Base Derivatives as Promising Anti-urease Agents
by: Masood, et al.
Published: (2024)

Efficient Energy Optimization Routing for WSN Based on Even-Odd Scheduling
by: Iqbal Khan M.Z.; Abd Jalil K.; Ibrahim M.F.
Published: (2022)

Synthesis of symmetrical bis-Schiff base-disulfide hybrids as highly effective anti-leishmanial agents
by: Taha M.; Sain A.A.; Ali M.; Anouar E.H.; Rahim F.; Ismail N.H.; Adenan M.I.; Imran S.; Al-Harrasi A.; Nawaz F.; Iqbal N.; Khan K.M.
Published: (2020)