Discovering biological efficacy of new thiadiazole as effective inhibitors of urease, glycation, and (DPPH) scavengers: Biochemical and in silico study

QR Code

Discovering biological efficacy of new thiadiazole as effective inhibitors of urease, glycation, and (DPPH) scavengers: Biochemical and in silico study

Thiadiazole is a potential class of α-glucosidase, β-glucuronidase, and anti-leishmanial inhibitors. Our aim was to develop thiadiazole based dual inhibitors for urease glycation inhibition and (DDPH) scavenging activity. Pyridine-based-thiadiazole analogs (1–18) were synthesized and characterized t...

Full description

Bibliographic Details
Published in:	Journal of Molecular Structure
Main Author:	Taha M.; Imran S.; Rahim F.; Uddin N.; Iqbal N.; Khan K.M.; Farooq R.K.; Alomari M.; Islam I.; Algheribe S.
Format:	Article
Language:	English
Published:	Elsevier B.V. 2023
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85141287162&doi=10.1016%2fj.molstruc.2022.134449&partnerID=40&md5=31cc37b083234dc40107e9711af90b0d

Similar Items

Synthesis of benzophenone hydrazone analogs and their DPPH radical scavenging and urease inhibitory activities
by: Khan K.M.; Rahim F.; Khan A.; Ali S.; Taha M.; Saad S.M.; Khan M.; Najeebullah; Shaikh A.; Perveen S.; Choudhary M.I.
Published: (2015)

Discovering the DPPH Free Radical Scavenging Activity of Azine Derivatives Bearing Ethyl Phenyl Ketone Moiety
by: Rehman M.U.; Alam A.; Shah S.A.A.; Ali A.; Ali Q.; AlAsmari A.F.; Alasmari F.; Khan M.
Published: (2024)

Discovering the DPPH Free Radical Scavenging Activity of Azine Derivatives Bearing Ethyl Phenyl Ketone Moiety
by: Rehman, et al.
Published: (2024)

Design, synthesis, in vitro evaluation, molecular docking and ADME properties studies of hybrid bis-coumarin with thiadiazole as a new inhibitor of Urease
by: Alomari M.; Taha M.; Imran S.; Jamil W.; Selvaraj M.; Uddin N.; Rahim F.
Published: (2019)

PHYTOCHEMICAL ANALYSIS AND DPPH RADICAL SCAVENGING ACTIVITY OF Plectranthus amboinicus (Lour.) Spreng LEAF EXTRACTS
by: Rojnan N.A.L.; Jani N.A.
Published: (2023)

Synthesis of new urease enzyme inhibitors as antiulcer drug and computational study
by: Taha M.; Ismail S.; Imran S.; Almandil N.B.; Alomari M.; Rahim F.; Uddin N.; Hayat S.; Zaman K.; Ibrahim M.; Alghanem B.; Islam I.; Farooq R.K.; Boudjelal M.; Khan K.M.
Published: (2022)

New biologically dynamic hybrid pharmacophore triazinoindole-based-thiadiazole as potent α-glucosidase inhibitors: In vitro and in silico study
by: Khan A.A.; Rahim F.; Taha M.; Rehman W.; Iqbal N.; Wadood A.; Ahmad N.; Shah S.A.A.; Ghoneim M.M.; Alshehri S.; Salahuddin M.; Khan K.M.
Published: (2022)

Synthesis of diindolylmethane (DIM) bearing thiadiazole derivatives as a potent urease inhibitor
by: Taha M.; Rahim F.; Khan A.A.; Anouar E.H.; Ahmed N.; Shah S.A.A.; Ibrahim M.; Zakari Z.A.
Published: (2020)

Convergent synthesis, free radical scavenging, Lineweaver-Burk plot exploration, hemolysis and in silico study of novel indole-phenyltriazole hybrid bearing acetamides as potent urease inhibitors
by: Khan W.; Abbasi M.A.; Rehman A.-U.; Siddiqui S.Z.; Nazir M.; Ali Shah S.A.; Raza H.; Hassan M.; Shahid M.; Seo S.Y.
Published: (2020)

Oxindole-based chalcones: synthesis and their activity against glycation of proteins
by: Khan A.; Khan A.; Farooq U.; Taha M.; Shah S.A.A.; Halim S.A.; Akram A.; Khan M.Z.; Jan A.K.; Al-Harrasi A.
Published: (2019)

Synthesis of oxadiazole-coupled-thiadiazole derivatives as a potent β-glucuronidase inhibitors and their molecular docking study
by: Taha M.; Imran S.; Alomari M.; Rahim F.; Wadood A.; Mosaddik A.; Uddin N.; Gollapalli M.; Alqahtani M.A.; Bamarouf Y.A.
Published: (2019)

Synthesis, in vitro evaluation and molecular docking studies of hybrid 4-quinolinyl bearing 1,3,4-thiadiazole-2-amine as a new inhibitor of α-amylase and α-glucosidase
by: Taha M.; Khan A.A.; Rahim F.; Hayat S.; Imran S.; Iqbal N.; Uddin N.; Khan K.M.; Anouar E.H.; Farooq R.K.; Nawaz M.; Shah S.A.A.
Published: (2023)

Synthesis and biological evaluation of pyridylpiperazine hybrid derivatives as urease inhibitors
by: Akash, et al.
Published: (2024)

Synthesis and biological evaluation of pyridylpiperazine hybrid derivatives as urease inhibitors
by: Akash M.; Zaib S.; Ahmad M.; Sultan S.; Al-Hussain S.A.
Published: (2024)

Pyridylpiperazine-based carbodithioates as urease inhibitors: synthesis and biological evaluation
by: Akash, et al.
Published: (2024)

Pyridylpiperazine-based carbodithioates as urease inhibitors: synthesis and biological evaluation
by: Akash M.; Rana N.; Aslam S.; Ahmad M.; Saif M.J.; Asghar A.; Sultan S.; Al-Hussain S.A.; Liaqat A.; Zaib S.; Zaki M.E.A.
Published: (2024)

Synthesis, in vitro urease inhibitory potential and molecular docking study of benzofuran-based-thiazoldinone analogues
by: Taha M.; Rahim F.; Ullah H.; Wadood A.; Farooq R.K.; Shah S.A.A.; Nawaz M.; Zakaria Z.A.
Published: (2020)

Biochemical, Toxicological, and in Silico Aspects of Trillium govanianum Wall. ex D.Don (Trilliaceae): A Rich Source of Natural Bioactive Compounds
by: Khan K.M.; Nadeem M.F.; Mannan A.; Chohan T.A.; Islam M.; Ansari S.A.; Alkahtani H.M.; Ansari I.A.; Khurshid U.; Abidin S.A.Z.; Shah S.A.A.; Saleem H.
Published: (2024)

Synthesis, in vitro α-glucosidase inhibitory potential and molecular docking study of thiadiazole analogs
by: Javid M.T.; Rahim F.; Taha M.; Rehman H.U.; Nawaz M.; wadood A.; Imran S.; Uddin I.; Mosaddik A.; Khan K.M.
Published: (2018)

Novel acyl hydrazide derivatives of polyhydroquinoline as potent anti-diabetic and anti-glycating agents: Synthesis, in vitro α-amylase, α-glucosidase inhibition and anti-glycating activity with molecular docking insights
by: Ur Rahman S.; Alam A.; Parveen Z.; Zainab; Assad M.; Adnan Ali Shah S.; Rafiq H.; Ayaz M.; Latif A.; Naveed Umar M.; Ali M.; Ahmad M.
Published: (2024)

Synthesis of modified 1,3,4-thiadiazole incorporating substituted thiosemicarbazide derivatives: Elucidating the in vitro and in silico studies to develop promising anti-diabetic agent
by: Abbasi S.A.; Rahim F.; Hussain R.; Khan S.; Ullah H.; Iqbal T.; Iqbal N.; Khan H.U.; Khan S.; Iqbal R.; Shah S.A.A.; Al Obaid S.; Ansari M.J.
Published: (2024)

Synthesis, in vitro biological analysis and molecular docking studies of new thiadiazole-based thiourea derivatives as dual inhibitors of a-amylase and a-glucosidase
by: Khan I.; Rehman W.; Rahim F.; Hussain R.; Khan S.; Rasheed L.; Alanazi A.S.; Hefnawy M.; Alanazi M.M.; Shah S.A.A.; Taha M.
Published: (2023)

Specialization of biochemical oxygen demand for surface water and wastewater
by: Nonzan A.N.; Rahman Z.Z.A.; Nurul F.M.
Published: (2011)

Synthesis of 4-thiazolidinone analogs as potent in vitro anti-urease agents
by: Rahim F.; Zaman K.; Ullah H.; Taha M.; Wadood A.; Javed M.T.; Rehman W.; Ashraf M.; Uddin R.; Uddin I.; Asghar H.; Khan A.A.; Khan K.M.
Published: (2015)

Peri-implant conditions and levels of advanced glycation end products among patients with different glycemic control
by: Al-Sowygh Z.H.; Ghani S.M.A.; Sergis K.; Vohra F.; Akram Z.
Published: (2018)

Thiadiazole derivatives as New Class of β-glucuronidase inhibitors
by: Salar U.; Taha M.; Ismail N.H.; Khan K.M.; Imran S.; Perveen S.; Wadood A.; Riaz M.
Published: (2016)

Discover the challenges faced by the smallholder in the loose fruit collection process
by: Forest I.L.; Yusuf S.M.W.; Saili A.R.; Mahdian S.; Rizieq R.
Published: (2024)

Active learning pedagogical dimensions: discovering and bridging the pedagogical gaps
by: Leow M.H.; Hassan N.; Mohd Sharizal S.A.; Razak R.A.
Published: (2024)

Evaluation and docking of indole sulfonamide as a potent inhibitor of α-glucosidase enzyme in streptozotocin –induced diabetic albino wistar rats
by: Taha M.; Imran S.; Salahuddin M.; Iqbal N.; Rahim F.; Uddin N.; Shehzad A.; Khalid Farooq R.; Alomari M.; Mohammed Khan K.
Published: (2021)

Biochemical modulation of lipid pathway in microalgae Dunaliella sp. for biodiesel production
by: Talebi A.F.; Tohidfar M.; Mousavi Derazmahalleh S.M.; Sulaiman A.; Baharuddin A.S.; Tabatabaei M.
Published: (2015)

Biochemical composition, morphology and antimicrobial susceptibility pattern of Corynebacterium pseudotuberculosis biofilm
by: Yaacob M.F.; Murata A.; Nor N.H.M.; Jesse F.F.A.; Raja Yahya M.F.Z.
Published: (2021)

Chemical Constituents and Radical Scavenging Activities from the Twigs of Dipterocarpus kerrii King
by: Azahar S.Z.; Adnan N.; Ghani N.Ab.; Azmin N.F.N.; Kamarozaman A.S.
Published: (2024)

Synthesis, in vitro antiurease, in vivo antinematodal activity of quinoline analogs and their in-silico study
by: Zaman K.; Rahim F.; Taha M.; Sajid M.; Hayat S.; Nawaz M.; Salahuddin M.; Iqbal N.; Khan N.U.; Shah S.A.A.; Farooq R.K.; Bahadar A.; Wadood A.; Khan K.M.
Published: (2021)

THE EFFECTS OF GENETIC VARIANTS TOWARDS WEIGHT AND BIOCHEMICAL CHANGES IN WEIGHT MANAGEMENT PROGRAM
by: Mohd Asmawi U.M.; Abdul Halim N.I.H.; Mohidin S.A.A.; Rajab N.; Kek T.L.; Salleh M.Z.; Mansyur M.; Md Nor N.
Published: (2023)

Use of glycated hemoglobin (HbA1c) and impaired glucose tolerance in the screening of undiagnosed diabetes in the Malaysian population
by: Qvist R.; Ismail I.S.; Chinna K.; Muniandy S.
Published: (2008)

Synthesis and study of the α-amylase inhibitory potential of thiadiazole quinoline derivatives
by: Taha M.; Tariq Javid M.; Imran S.; Selvaraj M.; Chigurupati S.; Ullah H.; Rahim F.; Khan F.; Islam Mohammad J.; Mohammed Khan K.
Published: (2017)

THE RELATIONSHIP OF BIOCHEMICAL MARKERS AND COAGULATION PROFILES WITH THE SURVIVAL STATUS AMONG COVID-19 PATIENTS
by: Samuri N.F.S.M.; Kasim N.A.M.; Isa M.R.; Monir M.A.; Rosli M.M.; Yusoff N.A.; Atikah S.K.
Published: (2024)

Improving antioxidant scavenging effect of fruit peel waste extracts and their applicability in biodiesel stability enhancement
by: Bello U.; Amran N.A.; Ruslan M.S.H.
Published: (2023)

Discovering Hate Sentiment within Twitter Data through Aspect-Based Sentiment Analysis
by: Zainuddin N.; Selamat A.; Ibrahim R.
Published: (2020)

Utilization of landscape biomass waste as activated carbon to scavenge oxytetracycline: Attraction mechanism, batch and continuous studies
by: Khan M.N.N.; Yusop M.F.M.; Latiff M.F.P.M.; Ahmad M.A.
Published: (2023)