Chemical composition and bioactivities of Magnolia candollii H.Keng essential oil

• Published in: Zeitschrift fur Naturforschung - Section C Journal of Biosciences
• Main Author: Hakim Yahaya A.A.; Nuzul Hakimi Wan Salleh W.M.; Ghani N.A.; Khamis S.; Rezali N.S.; Aizat Juhari M.A.
• Format: Article
• Language: English
• Published: De Gruyter Open Ltd 2022
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85137407883&doi=10.1515%2fznc-2022-0100&partnerID=40&md5=1778730621589e4179bdeb38fe569be5

Several Magnolia species have exhibited potent biological activities such as anti-inflammatory, anti-angiogenesis, anticonvulsant, anti-obesity, and antiviral activities. However, the Magnolia candollii from Malaysia has not been investigated yet. Hence, this study aims to investigate the chemical composition and bioactivities of the essential oil of Magnolia candollii H.Keng from Malaysia. The hydrodistillation process was used to produce the essential oil, and gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) were used to analyse it. In total, 44 chemical components were identified in the bark oil, accounting for 98.4%. The major components of the essential oil were α-pinene (29.7%), elemol (10.2%), β-pinene (8.5%), β-caryophyllene (7.2%), α-terpineol (7.0%), guaiol (5.4%), and bulnesol (4.9%). Acetylcholinesterase and anti-inflammatory activities were also evaluated using the Ellman method and lipoxygenase enzyme, respectively, in which the essential oil showed moderate inhibitory activity against acetylcholinesterase (I%: 70.2%) and lipoxygenase (I%: 72.5%). Thus, the findings may be helpful for identifying the medicinal and therapeutic uses of the essential oil from the Magnolia genus. © 2022 Walter de Gruyter GmbH, Berlin/Boston.