Lactobacillus Spp.-Enhanced Memory is Strain-Dependent and Associated, in Part, with Amyloidogenic and anti-Oxidant/Oxidative Stress Interplay in Amyloid Beta Precursor Protein Transgenic Mice
This study explored mechanisms underpinning enhanced memory in amyloid precursor protein (APP) transgenic mice (male; 10-12 months; n = 6/group) supplemented with Lactobacillus plantarum LAB12 (LAB12)/Lactobacillus casei Shirota (LcS). Morris Water Maze test was performed before brains were harveste...
Published in: | Journal of Dietary Supplements |
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Taylor and Francis Ltd.
2023
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2-s2.0-85134664057 Ahmad Alwi N.A.; Lim S.M.; Mani V.; Ramasamy K. Lactobacillus Spp.-Enhanced Memory is Strain-Dependent and Associated, in Part, with Amyloidogenic and anti-Oxidant/Oxidative Stress Interplay in Amyloid Beta Precursor Protein Transgenic Mice 2023 Journal of Dietary Supplements 20 5 10.1080/19390211.2022.2103608 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85134664057&doi=10.1080%2f19390211.2022.2103608&partnerID=40&md5=e898032e26a977eb6a4e1cf14a99d69a This study explored mechanisms underpinning enhanced memory in amyloid precursor protein (APP) transgenic mice (male; 10-12 months; n = 6/group) supplemented with Lactobacillus plantarum LAB12 (LAB12)/Lactobacillus casei Shirota (LcS). Morris Water Maze test was performed before brains were harvested for gene expression and biochemical studies. LAB-supplemented mice exhibited reduced escape latency and distance but significant increased time spent in platform zone. This was associated with downregulated beta-site APP cleaving enzyme-1 (BACE1) mRNA and significant reduced nitric oxide in brains. LAB12 also significantly increased glutathione. The LAB-enhanced memory is strain-dependent and could be mediated, in part, through amyloidogenic pathway and anti-oxidant/oxidative stress interplay. © 2022 Taylor & Francis Group, LLC. Taylor and Francis Ltd. 19390211 English Article |
author |
Ahmad Alwi N.A.; Lim S.M.; Mani V.; Ramasamy K. |
spellingShingle |
Ahmad Alwi N.A.; Lim S.M.; Mani V.; Ramasamy K. Lactobacillus Spp.-Enhanced Memory is Strain-Dependent and Associated, in Part, with Amyloidogenic and anti-Oxidant/Oxidative Stress Interplay in Amyloid Beta Precursor Protein Transgenic Mice |
author_facet |
Ahmad Alwi N.A.; Lim S.M.; Mani V.; Ramasamy K. |
author_sort |
Ahmad Alwi N.A.; Lim S.M.; Mani V.; Ramasamy K. |
title |
Lactobacillus Spp.-Enhanced Memory is Strain-Dependent and Associated, in Part, with Amyloidogenic and anti-Oxidant/Oxidative Stress Interplay in Amyloid Beta Precursor Protein Transgenic Mice |
title_short |
Lactobacillus Spp.-Enhanced Memory is Strain-Dependent and Associated, in Part, with Amyloidogenic and anti-Oxidant/Oxidative Stress Interplay in Amyloid Beta Precursor Protein Transgenic Mice |
title_full |
Lactobacillus Spp.-Enhanced Memory is Strain-Dependent and Associated, in Part, with Amyloidogenic and anti-Oxidant/Oxidative Stress Interplay in Amyloid Beta Precursor Protein Transgenic Mice |
title_fullStr |
Lactobacillus Spp.-Enhanced Memory is Strain-Dependent and Associated, in Part, with Amyloidogenic and anti-Oxidant/Oxidative Stress Interplay in Amyloid Beta Precursor Protein Transgenic Mice |
title_full_unstemmed |
Lactobacillus Spp.-Enhanced Memory is Strain-Dependent and Associated, in Part, with Amyloidogenic and anti-Oxidant/Oxidative Stress Interplay in Amyloid Beta Precursor Protein Transgenic Mice |
title_sort |
Lactobacillus Spp.-Enhanced Memory is Strain-Dependent and Associated, in Part, with Amyloidogenic and anti-Oxidant/Oxidative Stress Interplay in Amyloid Beta Precursor Protein Transgenic Mice |
publishDate |
2023 |
container_title |
Journal of Dietary Supplements |
container_volume |
20 |
container_issue |
5 |
doi_str_mv |
10.1080/19390211.2022.2103608 |
url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85134664057&doi=10.1080%2f19390211.2022.2103608&partnerID=40&md5=e898032e26a977eb6a4e1cf14a99d69a |
description |
This study explored mechanisms underpinning enhanced memory in amyloid precursor protein (APP) transgenic mice (male; 10-12 months; n = 6/group) supplemented with Lactobacillus plantarum LAB12 (LAB12)/Lactobacillus casei Shirota (LcS). Morris Water Maze test was performed before brains were harvested for gene expression and biochemical studies. LAB-supplemented mice exhibited reduced escape latency and distance but significant increased time spent in platform zone. This was associated with downregulated beta-site APP cleaving enzyme-1 (BACE1) mRNA and significant reduced nitric oxide in brains. LAB12 also significantly increased glutathione. The LAB-enhanced memory is strain-dependent and could be mediated, in part, through amyloidogenic pathway and anti-oxidant/oxidative stress interplay. © 2022 Taylor & Francis Group, LLC. |
publisher |
Taylor and Francis Ltd. |
issn |
19390211 |
language |
English |
format |
Article |
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scopus |
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Scopus |
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1809677890839642112 |