Lactobacillus Spp.-Enhanced Memory is Strain-Dependent and Associated, in Part, with Amyloidogenic and anti-Oxidant/Oxidative Stress Interplay in Amyloid Beta Precursor Protein Transgenic Mice
This study explored mechanisms underpinning enhanced memory in amyloid precursor protein (APP) transgenic mice (male; 10-12 months; n = 6/group) supplemented with Lactobacillus plantarum LAB12 (LAB12)/Lactobacillus casei Shirota (LcS). Morris Water Maze test was performed before brains were harveste...
| Published in: | Journal of Dietary Supplements |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Taylor and Francis Ltd.
2023
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85134664057&doi=10.1080%2f19390211.2022.2103608&partnerID=40&md5=e898032e26a977eb6a4e1cf14a99d69a |
| Summary: | This study explored mechanisms underpinning enhanced memory in amyloid precursor protein (APP) transgenic mice (male; 10-12 months; n = 6/group) supplemented with Lactobacillus plantarum LAB12 (LAB12)/Lactobacillus casei Shirota (LcS). Morris Water Maze test was performed before brains were harvested for gene expression and biochemical studies. LAB-supplemented mice exhibited reduced escape latency and distance but significant increased time spent in platform zone. This was associated with downregulated beta-site APP cleaving enzyme-1 (BACE1) mRNA and significant reduced nitric oxide in brains. LAB12 also significantly increased glutathione. The LAB-enhanced memory is strain-dependent and could be mediated, in part, through amyloidogenic pathway and anti-oxidant/oxidative stress interplay. © 2022 Taylor & Francis Group, LLC. |
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| ISSN: | 19390211 |
| DOI: | 10.1080/19390211.2022.2103608 |