FIVE-MEMBERED NITROGEN HETEROCYCLES AS NEW LEAD COMPOUNDS IN DRUG DISCOVERY

QR Code

FIVE-MEMBERED NITROGEN HETEROCYCLES AS NEW LEAD COMPOUNDS IN DRUG DISCOVERY

Five-membered nitrogen heterocyclic compounds are a very important group with various pharmaceutical properties. The different substitutions and functionalization of these compounds contributed to various biological activities. Five-membered nitrogen heterocyclic scaffolds are used for synthesizing...

Full description

Bibliographic Details
Published in:	Heterocycles
Main Author:	Wibowo A.; Mohammat M.F.; Shaameri Z.; Rashid F.N.A.A.; Pungot N.H.; Hamzah A.S.
Format:	Review
Language:	English
Published:	Japan Institute of Heterocyclic Chemistry 2022
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85133851533&doi=10.3987%2fREV-22-SR%28R%297&partnerID=40&md5=2b9671e44762923d77272aaa5bf6888c

Similar Items

Five-membered nitrogen heterocyclic compounds
by: Hamzah A.S.; Shaameri Z.; Goksu S.
Published: (2013)

A multi-component reaction approach to the synthesis of potent antidiabetic agents five-membered iminosugars analogues
by: Wibowo A.; Shaameri Z.; Mohammat M.F.; Hamzah A.S.
Published: (2020)

Biotransformation of steroids: Accelerating discovery of new drugs in the pharmaceutical industry
by: Sultan S.; Singh G.K.S.; Ashraf K.; Ashraf M.
Published: (2023)

Unveiling dynamics of nitrogen content and selected nitrogen heterocycles in thrombin inhibitors: a ceteris paribus approach
by: Masand V.H.; Al-Hussain S.; Alzahrani A.Y.; Al-Mutairi A.A.; Sultan Alqahtani A.; Samad A.; Alafeefy A.M.; Jawarkar R.D.; Zaki M.E.A.
Published: (2024)

Synthesis of novel 3,4-fused pyrazolidinone γ-lactam bicyclic moieties from 2,3-dioxo-4-carboxy-5-(substituted)pyrrolidines
by: Rashid F.N.A.A.; Mohammat M.F.; Shaameri Z.; Hamzah A.S.
Published: (2019)

A review of bisindolylmethane as an important scaffold for drug discovery
by: Imran S.; Taha M.; Ismail N.H.
Published: (2015)

Alkaloids as Antimalarial Compounds: A Review of Recent Studies
by: Saufi N.A.U.M.; Hatta U.U.M.; Rashid F.N.A.A.; Mohammat M.F.
Published: (2023)

Discovery of polymethoxyflavones as potential cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX) and phosphodiesterase 4B (PDE4B) inhibitors
by: Md Idris M.H.; Mohd Amin S.N.; Mohd Amin S.N.; Wibowo A.; Zakaria Z.A.; Shaameri Z.; Hamzah A.S.; Selvaraj M.; Teh L.K.; Salleh M.Z.
Published: (2022)

Practical synthesis and electronic study of non-spiro and spiropyrano[2,3-c]pyrazole-3-carboxylate derivatives via uncatalyzed domino one-pot, four-component reactions
by: Mohammat M.F.; Maarop M.S.; Shaameri Z.; Wibowo A.; Johari S.A.; Hamzah A.S.
Published: (2018)

Computational approaches: Discovery of GTPase HRas as prospective drug target for 1,3-diazine scaffolds
by: Kumar S.; Sharma D.; Narasimhan B.; Ramasamy K.; Shah S.A.A.; Lim S.M.; Mani V.
Published: (2019)

Effectiveness of SteFib in composite structural member
by: Rahman N.A.; Hamzah S.H.; Abdulrazzaq A.
Published: (2012)

Reverse pharmacophore mapping and molecular docking studies for discovery of GTPase HRas as promising drug target for bis-pyrimidine derivatives
by: Kumar S.; Singh J.; Narasimhan B.; Shah S.A.A.; Lim S.M.; Ramasamy K.; Mani V.
Published: (2018)

Synthesis of 2,3-dioxo-5-(substituted)arylpyrroles and their 2-oxo-5-aryl-3-hydrazone pyrrolidine derivatives
by: Mohammat M.F.; Shaameri Z.; Hamzah A.S.
Published: (2009)

Synthesis of Trans-4-Hydroxyprolineamide and 3-Ketoproline Ethyl Ester for Green Asymmetric Organocatalysts
by: Abdullah N.; Shaameri Z.; Hamzah A.S.; Mohammat M.F.
Published: (2024)

First consecutive linear synthesis of hostmaniene, 5-formyl-2- (isopropyl-l'-ol)benzofuran and anadendroic acid using prenylated phenol
by: Mohammat M.F.; Osman N.S.; Shaameri Z.; Hamzah A.S.
Published: (2017)

Diastereoselective reduction of 2,3-dioxo-4-carboxy-5-substituted pyrrolidines using NaBH4/AcOH and heterogenous hydrogenation reactions
by: Mohammat M.F.; Mansor N.S.; Shaameri Z.; Hamzah A.S.
Published: (2015)

Features of Trust in Online Guanxi among Malaysian Web-Forum Members
by: Shanthi A.; Thayalan X.; Xavierine J.
Published: (2018)

Knowledge Discovery from the Digital Library’s Contents: Bangladesh Perspective
by: Rahman M.H.; Zakaria S.; Ahmad A.
Published: (2021)

A Bibliometric Analysis of Iminosugars-related Studies
by: Rosli N.H.M.; Ahmi A.; Wibowo A.; Mohammat M.F.; Hamzah A.S.
Published: (2023)

Alkaloids as Antimalarial Compounds: A Review of Recent Studies
by: Saufi, et al.
Published: (2023)

Alkaloids as Antimalarial Compounds: A Review of Recent Studies
by: Saufi, et al.
Published: (2023)

New piperidinyl heterocyclic azoles acquired through Li(I)-catalyzed reactions: Anti-enzymatic, ADME and computational studies
by: Hamid S.; Amjad H.; Abbasi M.A.; Siddiqui S.Z.; Ashraf M.; Iqbal J.; Farhan M.; Rasool S.; Shah S.A.A.; Imran S.; Rehman M.T.; Rehman A.-U.
Published: (2024)

The Factors Associated Inadequacy Retirement Fund Among Employee Provident Fund (EPF) Members
by: Zainudin R.A.; Izwan N.A.I.M.A.; Samian M.H.; Ariffin A.F.; Shamsuddin S.N.; Juanis D.J.
Published: (2024)

Assessing the Relationship of Skills and Performance: An Exploratory Study of Religious Based Cooperatives’ Board Members
by: Abdullah Salim A.S.; Mustafa M.A.; Yatim N.M.; Masuod M.S.; Abu Said A.M.; Abdullah Sani N.
Published: (2024)

Influence of impression management on interpersonal citizenship behavior: Leader-member exchange as a mediator
by: Noranee S.; Ishak N.D.A.; Mustapha R.M.R.
Published: (2012)

The roles of mosque in sympathizing the kariah members during the movement control order (MCO) period
by: Salleh J.M.; Karim M.S.; Kedin N.A.; Sulaiman S.B.
Published: (2021)

DISCOVERY ON MALAYSIAN ESL TEACHERS’ ADHERENCE TO POLICY MANDATES IN CLASSROOMBASED ASSESSMENT PRACTICES
by: Marzaini A.F.M.; Yusoff S.M.; Zakaria N.; Basal M.H.; Sharil W.N.E.H.; Supramaniam K.
Published: (2024)

Unsaturated 15 and 16 Membered Appended Naphthalene Macrocyclic Molecules for the Development of Fluorometric Chemosensors
by: Hasan S.; Salleh S.; Hamdan S.; Yamin B.
Published: (2017)

BSA Binding, molecular docking and in vitro biological screening of some new 1, 2, 4-triazole heterocycles bearing azinane nucleus
by: Iqbal J.; Aziz-Ur-Rehman; Abbasi M.A.; Siddiqui S.Z.; Khalid H.; Laulloo S.J.; Chohan T.A.; Rasool S.; Ali Shah S.A.
Published: (2020)

Assessing the big five personality on categories of athletes and gender among tennis players
by: Hamzah S.R.S.; Rahim M.R.A.; Wan Pa W.A.M.; Mohamed Shapie M.N.; Abdullah N.M.; Parnabas V.
Published: (2022)

Forgive and Forget: Can Brand Transgression Lead to Behavioral Intention?
by: Rashid M.H.A.; Hamzah M.I.; Muhamat A.A.; Mansor A.A.; Hasanordin R.
Published: (2023)

New phase of lead chalcogenide alloy: Ternary alloy PbSrSe2 for future thermoelectric application
by: Low L.C.; Chang Y.H.R.; Yong Y.S.; Lim T.L.; Yoon T.L.; Lim K.M.
Published: (2022)

Synthesis of new urease enzyme inhibitors as antiulcer drug and computational study
by: Taha M.; Ismail S.; Imran S.; Almandil N.B.; Alomari M.; Rahim F.; Uddin N.; Hayat S.; Zaman K.; Ibrahim M.; Alghanem B.; Islam I.; Farooq R.K.; Boudjelal M.; Khan K.M.
Published: (2022)

A DISCOVERY ON MALAYSIAN ESL TEACHERS' ADHERENCE TO POLICY MANDATES IN CLASSROOM- BASED ASSESSMENT PRACTICES
by: Marzaini, et al.
Published: (2024)

Discovery of Biomarkers for Myogenous Temporomandibular Disorders Through Salivary Metabolomic Profiling: A Pilot Study
by: Khoo, et al.
Published: (2023)

Discovery of Biomarkers for Myogenous Temporomandibular Disorders Through Salivary Metabolomic Profiling: A Pilot Study
by: Khoo S.C.; Shoji Y.; Teh C.H.; Ma N.L.
Published: (2023)

Room Temperature Nitrogen Plasma Treatment for Advanced Wound Healing Functionality; [Rawatan Plasma Nitrogen Suhu Bilik untuk Peningkatan Fungsi Penyembuhan Pembalut Luka]
by: Mohd Akhiri A.S.; Abdul Aziz L.H.; Abd Hair A.H.; Zakaria S.; Awang R.
Published: (2024)

Impact of Varied Lead Concentrations on Lead Accumulation in the Body, Heart and Gill Damage of Milkfish (Chanos chanos)
by: Sukardi R.W.; Djawad M.I.; Azis H.Y.; Manaf S.R.
Published: (2024)

Review on Synthesis of (S)-5-Benzylpyrrolidine-2,4-dione Derivatives with Substitution at C-3 Position by Employing Functional Groups Interconversion
by: Zulkifli M.; Pungot N.H.; Abdullah N.; Ash’ari N.A.N.; Shaameri Z.
Published: (2022)

Bibliometric Assessment and Research Trends: Five Decades of Brand Image
by: Ya’kob S.A.; Baharun R.; Hamid S.N.A.; Mohamad M.
Published: (2024)