FIVE-MEMBERED NITROGEN HETEROCYCLES AS NEW LEAD COMPOUNDS IN DRUG DISCOVERY

• Published in: Heterocycles
• Main Author: Wibowo A.; Mohammat M.F.; Shaameri Z.; Rashid F.N.A.A.; Pungot N.H.; Hamzah A.S.
• Format: Review
• Language: English
• Published: Japan Institute of Heterocyclic Chemistry 2022
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85133851533&doi=10.3987%2fREV-22-SR%28R%297&partnerID=40&md5=2b9671e44762923d77272aaa5bf6888c

Five-membered nitrogen heterocyclic compounds are a very important group with various pharmaceutical properties. The different substitutions and functionalization of these compounds contributed to various biological activities. Five-membered nitrogen heterocyclic scaffolds are used for synthesizing numerous natural and synthetic compounds with a significant biological application. They include antidiabetic, anticancer, antimalarial, antiviral, antimicrobial, anti-inflammatory, antibacterial, and anti-neurodegenerative agents. This mini-review provides an overview of the biological activities and the synthetic methods for preparing the five-membered nitrogen heterocyclic scaffolds and their functionalization. In the final part, this mini-review also listed some commercial drugs containing five-membered nitrogen heterocyclic motifs, highlighting the versatility of the five-membered nitrogen heterocyclic core in drug discovery. © 2022 The Japan Institute of Heterocyclic Chemistry.