Asymmetric Synthesis of Hydroxy N,O-Heterobicyclic Octanes
A new asymmetric synthesis of several hydroxy N,O-heterobicyclic octanes is described in this paper. The synthesis employed Salen catalysed epoxide ring opening of the starting material meso-cyclohexene followed by the azide reduction and NBoc protection of (1S,6S)-6-azido-3-cyclohexenol, allylic hy...
| Published in: | Malaysian Journal of Chemistry |
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| Main Author: | |
| Format: | Conference paper |
| Language: | English |
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Malaysian Institute of Chemistry
2022
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85133513339&partnerID=40&md5=a1bf76ed85bd8ee08de14a84a9df42c3 |
| Summary: | A new asymmetric synthesis of several hydroxy N,O-heterobicyclic octanes is described in this paper. The synthesis employed Salen catalysed epoxide ring opening of the starting material meso-cyclohexene followed by the azide reduction and NBoc protection of (1S,6S)-6-azido-3-cyclohexenol, allylic hydroxylation and lactonization with final carbonyl reduction to produce hydroxy N,O-heterobicyclic octane. © 2022 Malaysian Institute of Chemistry. All rights reserved. |
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| ISSN: | 15112292 |