Natural Product-based Nanomedicine: Recent Advances and Issues for the Treatment of Alzheimer's Disease

Alzheimer's disease (AD) affects the elderly and is characterized by progressive neuro-degeneration caused by different pathologies. The most significant challenges in treating AD in-clude the inability of medications to reach the brain because of its poor solubility, low bioavailabil-ity, and...

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Published in:Current Neuropharmacology
Main Author: Woon C.K.; Hui W.K.; Abas R.; Haron M.H.; Das S.; Lin T.S.
Format: Review
Language:English
Published: Bentham Science Publishers 2022
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85132808377&doi=10.2174%2f1570159X20666211217163540&partnerID=40&md5=27b66d0a597aee1a9a5c90c2750ee872
id 2-s2.0-85132808377
spelling 2-s2.0-85132808377
Woon C.K.; Hui W.K.; Abas R.; Haron M.H.; Das S.; Lin T.S.
Natural Product-based Nanomedicine: Recent Advances and Issues for the Treatment of Alzheimer's Disease
2022
Current Neuropharmacology
20
8
10.2174/1570159X20666211217163540
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85132808377&doi=10.2174%2f1570159X20666211217163540&partnerID=40&md5=27b66d0a597aee1a9a5c90c2750ee872
Alzheimer's disease (AD) affects the elderly and is characterized by progressive neuro-degeneration caused by different pathologies. The most significant challenges in treating AD in-clude the inability of medications to reach the brain because of its poor solubility, low bioavailabil-ity, and the presence of the blood-brain barrier (BBB). Additionally, current evidence suggests the disruption of BBB plays an important role in the pathogenesis of AD. One of the critical challenges in treating AD is the ineffective treatments and their severe adverse effects. Nanotechnology offers an alternative approach to facilitate the treatment of AD by overcoming the challenges in drug transport across the BBB. Various nanoparticles (NP) loaded with natural products were reported to aid in drug delivery for the treatment of AD. The nano-sized entities of NP are great platforms for incorporating active materials from natural products into formulations that can be delivered effectively to the intended action site without compromising the material's bioactivity. The review high-lights the applications of medicinal plants, their derived components, and various nanomedicine-based approaches for the treatment of AD. The combination of medicinal plants and nanotechnology may lead to new theragnostic solutions for the treatment of AD in the future. © 2022 Bentham Science Publishers.
Bentham Science Publishers
1570159X
English
Review
All Open Access; Green Open Access
author Woon C.K.; Hui W.K.; Abas R.; Haron M.H.; Das S.; Lin T.S.
spellingShingle Woon C.K.; Hui W.K.; Abas R.; Haron M.H.; Das S.; Lin T.S.
Natural Product-based Nanomedicine: Recent Advances and Issues for the Treatment of Alzheimer's Disease
author_facet Woon C.K.; Hui W.K.; Abas R.; Haron M.H.; Das S.; Lin T.S.
author_sort Woon C.K.; Hui W.K.; Abas R.; Haron M.H.; Das S.; Lin T.S.
title Natural Product-based Nanomedicine: Recent Advances and Issues for the Treatment of Alzheimer's Disease
title_short Natural Product-based Nanomedicine: Recent Advances and Issues for the Treatment of Alzheimer's Disease
title_full Natural Product-based Nanomedicine: Recent Advances and Issues for the Treatment of Alzheimer's Disease
title_fullStr Natural Product-based Nanomedicine: Recent Advances and Issues for the Treatment of Alzheimer's Disease
title_full_unstemmed Natural Product-based Nanomedicine: Recent Advances and Issues for the Treatment of Alzheimer's Disease
title_sort Natural Product-based Nanomedicine: Recent Advances and Issues for the Treatment of Alzheimer's Disease
publishDate 2022
container_title Current Neuropharmacology
container_volume 20
container_issue 8
doi_str_mv 10.2174/1570159X20666211217163540
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85132808377&doi=10.2174%2f1570159X20666211217163540&partnerID=40&md5=27b66d0a597aee1a9a5c90c2750ee872
description Alzheimer's disease (AD) affects the elderly and is characterized by progressive neuro-degeneration caused by different pathologies. The most significant challenges in treating AD in-clude the inability of medications to reach the brain because of its poor solubility, low bioavailabil-ity, and the presence of the blood-brain barrier (BBB). Additionally, current evidence suggests the disruption of BBB plays an important role in the pathogenesis of AD. One of the critical challenges in treating AD is the ineffective treatments and their severe adverse effects. Nanotechnology offers an alternative approach to facilitate the treatment of AD by overcoming the challenges in drug transport across the BBB. Various nanoparticles (NP) loaded with natural products were reported to aid in drug delivery for the treatment of AD. The nano-sized entities of NP are great platforms for incorporating active materials from natural products into formulations that can be delivered effectively to the intended action site without compromising the material's bioactivity. The review high-lights the applications of medicinal plants, their derived components, and various nanomedicine-based approaches for the treatment of AD. The combination of medicinal plants and nanotechnology may lead to new theragnostic solutions for the treatment of AD in the future. © 2022 Bentham Science Publishers.
publisher Bentham Science Publishers
issn 1570159X
language English
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accesstype All Open Access; Green Open Access
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