Review on Synthesis of (S)-5-Benzylpyrrolidine-2,4-dione Derivatives with Substitution at C-3 Position by Employing Functional Groups Interconversion

Review on Synthesis of (S)-5-Benzylpyrrolidine-2,4-dione Derivatives with Substitution at C-3 Position by Employing Functional Groups Interconversion

5-benzylpyrrolidine-2,4-dione 9 are versatile scaffolds with a unique structural feature responsible for the diversity of its biological importance. Over the past years, many researchers have reported the synthesis of various bio-active (S)-5-benzylpyrrolidine-2,4-dione derivatives due to their simp...

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Published in:Mini-Reviews in Organic Chemistry
Main Author: Zulkifli M.; Pungot N.H.; Abdullah N.; Ash’ari N.A.N.; Shaameri Z.
Format: Article
Language:English
Published: Bentham Science Publishers 2022
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85132267308&doi=10.2174%2f1570193X19666220110121158&partnerID=40&md5=7effce52750d4691c4d5ef27cc163945
id 2-s2.0-85132267308
spelling 2-s2.0-85132267308
Zulkifli M.; Pungot N.H.; Abdullah N.; Ash’ari N.A.N.; Shaameri Z.
Review on Synthesis of (S)-5-Benzylpyrrolidine-2,4-dione Derivatives with Substitution at C-3 Position by Employing Functional Groups Interconversion
2022
Mini-Reviews in Organic Chemistry
19
6
10.2174/1570193X19666220110121158
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85132267308&doi=10.2174%2f1570193X19666220110121158&partnerID=40&md5=7effce52750d4691c4d5ef27cc163945
5-benzylpyrrolidine-2,4-dione 9 are versatile scaffolds with a unique structural feature responsible for the diversity of its biological importance. Over the past years, many researchers have reported the synthesis of various bio-active (S)-5-benzylpyrrolidine-2,4-dione derivatives due to their simplicity yet exhibiting promising bioactivities. This review focuses on the synthesis of core structure 9 and its derivatives based on the substitution at carbon-3 position of (S)-5-benzylpyrrolidine2,4-dione 9. This review also reported the effective method for the synthesis of core structure 9 with a 98% yield. Biological evaluations of various prepared derivatives by various researchers were described. © 2022 Bentham Science Publishers.
Bentham Science Publishers
1570193X
English
Article
author Zulkifli M.; Pungot N.H.; Abdullah N.; Ash’ari N.A.N.; Shaameri Z.
spellingShingle Zulkifli M.; Pungot N.H.; Abdullah N.; Ash’ari N.A.N.; Shaameri Z.
Review on Synthesis of (S)-5-Benzylpyrrolidine-2,4-dione Derivatives with Substitution at C-3 Position by Employing Functional Groups Interconversion
author_facet Zulkifli M.; Pungot N.H.; Abdullah N.; Ash’ari N.A.N.; Shaameri Z.
author_sort Zulkifli M.; Pungot N.H.; Abdullah N.; Ash’ari N.A.N.; Shaameri Z.
title Review on Synthesis of (S)-5-Benzylpyrrolidine-2,4-dione Derivatives with Substitution at C-3 Position by Employing Functional Groups Interconversion
title_short Review on Synthesis of (S)-5-Benzylpyrrolidine-2,4-dione Derivatives with Substitution at C-3 Position by Employing Functional Groups Interconversion
title_full Review on Synthesis of (S)-5-Benzylpyrrolidine-2,4-dione Derivatives with Substitution at C-3 Position by Employing Functional Groups Interconversion
title_fullStr Review on Synthesis of (S)-5-Benzylpyrrolidine-2,4-dione Derivatives with Substitution at C-3 Position by Employing Functional Groups Interconversion
title_full_unstemmed Review on Synthesis of (S)-5-Benzylpyrrolidine-2,4-dione Derivatives with Substitution at C-3 Position by Employing Functional Groups Interconversion
title_sort Review on Synthesis of (S)-5-Benzylpyrrolidine-2,4-dione Derivatives with Substitution at C-3 Position by Employing Functional Groups Interconversion
publishDate 2022
container_title Mini-Reviews in Organic Chemistry
container_volume 19
container_issue 6
doi_str_mv 10.2174/1570193X19666220110121158
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85132267308&doi=10.2174%2f1570193X19666220110121158&partnerID=40&md5=7effce52750d4691c4d5ef27cc163945
description 5-benzylpyrrolidine-2,4-dione 9 are versatile scaffolds with a unique structural feature responsible for the diversity of its biological importance. Over the past years, many researchers have reported the synthesis of various bio-active (S)-5-benzylpyrrolidine-2,4-dione derivatives due to their simplicity yet exhibiting promising bioactivities. This review focuses on the synthesis of core structure 9 and its derivatives based on the substitution at carbon-3 position of (S)-5-benzylpyrrolidine2,4-dione 9. This review also reported the effective method for the synthesis of core structure 9 with a 98% yield. Biological evaluations of various prepared derivatives by various researchers were described. © 2022 Bentham Science Publishers.
publisher Bentham Science Publishers
issn 1570193X
language English
format Article
accesstype
record_format scopus
collection Scopus
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