Review on Synthesis of (S)-5-Benzylpyrrolidine-2,4-dione Derivatives with Substitution at C-3 Position by Employing Functional Groups Interconversion

• Published in: Mini-Reviews in Organic Chemistry
• Main Author: Zulkifli M.; Pungot N.H.; Abdullah N.; Ash’ari N.A.N.; Shaameri Z.
• Format: Article
• Language: English
• Published: Bentham Science Publishers 2022
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85132267308&doi=10.2174%2f1570193X19666220110121158&partnerID=40&md5=7effce52750d4691c4d5ef27cc163945
• ISSN: 1570193X
• DOI: 10.2174/1570193X19666220110121158

5-benzylpyrrolidine-2,4-dione 9 are versatile scaffolds with a unique structural feature responsible for the diversity of its biological importance. Over the past years, many researchers have reported the synthesis of various bio-active (S)-5-benzylpyrrolidine-2,4-dione derivatives due to their simplicity yet exhibiting promising bioactivities. This review focuses on the synthesis of core structure 9 and its derivatives based on the substitution at carbon-3 position of (S)-5-benzylpyrrolidine2,4-dione 9. This review also reported the effective method for the synthesis of core structure 9 with a 98% yield. Biological evaluations of various prepared derivatives by various researchers were described. © 2022 Bentham Science Publishers.