Tumor Suppressive Effects of GAS5 in Cancer Cells

• Published in: Non-coding RNA
• Main Author: Kaur J.; Salehen N.; Norazit A.; Rahman A.A.; Murad N.A.A.; Rahman N.M.A.N.A.; Ibrahim K.
• Format: Review
• Language: English
• Published: MDPI 2022
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85131243711&doi=10.3390%2fncrna8030039&partnerID=40&md5=573baf8dcc154d8778ea2ebee7bf0426

In recent years, long non-coding RNAs (lncRNAs) have been shown to play important regulatory roles in cellular processes. Growth arrests specific transcript 5 (GAS5) is a lncRNA that is highly expressed during the cell cycle arrest phase but is downregulated in actively growing cells. Growth arrests specific transcript 5 was discovered to be downregulated in several cancers, primarily solid tumors, and it is known as a tumor suppressor gene that regulates cell proliferation, invasion, migration, and apoptosis via multiple molecular mechanisms. Furthermore, GAS5 polymorphism was found to affect GAS5 expression and functionality in a cell-specific manner. This review arti-cle focuses on GAS5’s tumor-suppressive effects in regulating oncogenic signaling pathways, cell cycle, apoptosis, tumor-associated genes, and treatment-resistant cells. We also discussed genetic polymorphisms of GAS5 and their association with cancer susceptibility. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.