N-Sulfonated derivatives of (2-furoyl)piperazine: Promising antibacterial agents with mild cytotoxicity

N-Sulfonated derivatives of (2-furoyl)piperazine: Promising antibacterial agents with mild cytotoxicity

2-Furoyl-1-piperazine (1) was treated with a series of alkyl/aryl sulfonyl chlorides (2a-i) under benignant conditions to obtain its N-sulfonated derivatives (3a-i). These compounds were screened for their antibacterial potential against pathogenic bacteria. The low Minimum Inhibitory Concentration...

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Published in:Pakistan Journal of Pharmaceutical Sciences
Main Author: Abbasi M.A.; Irshad M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.
Format: Article
Language:English
Published: Pakistan Journal of Pharmaceutical Sciences 2022
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85129082085&doi=10.36721%2fPJPS.2022.35.2.REG.579-585.1&partnerID=40&md5=74e3ec50e089893dfa55a5cc8fc0dfa0
id 2-s2.0-85129082085
spelling 2-s2.0-85129082085
Abbasi M.A.; Irshad M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.
N-Sulfonated derivatives of (2-furoyl)piperazine: Promising antibacterial agents with mild cytotoxicity
2022
Pakistan Journal of Pharmaceutical Sciences
35
2
10.36721/PJPS.2022.35.2.REG.579-585.1
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85129082085&doi=10.36721%2fPJPS.2022.35.2.REG.579-585.1&partnerID=40&md5=74e3ec50e089893dfa55a5cc8fc0dfa0
2-Furoyl-1-piperazine (1) was treated with a series of alkyl/aryl sulfonyl chlorides (2a-i) under benignant conditions to obtain its N-sulfonated derivatives (3a-i). These compounds were screened for their antibacterial potential against pathogenic bacteria. The low Minimum Inhibitory Concentration (MIC) values of these molecules, in comparison of ciprofloxacin, demonstrated their high antibacterial potential. Cytotoxic activities were ascertained through their hemolytic potential and mild hemolytic profiles of these compounds proved them to be promising compounds for drug designing and development. © 2022 Pakistan Journal of Pharmaceutical Sciences. All rights reserved.
Pakistan Journal of Pharmaceutical Sciences
1011601X
English
Article
author Abbasi M.A.; Irshad M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.
spellingShingle Abbasi M.A.; Irshad M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.
N-Sulfonated derivatives of (2-furoyl)piperazine: Promising antibacterial agents with mild cytotoxicity
author_facet Abbasi M.A.; Irshad M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.
author_sort Abbasi M.A.; Irshad M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.
title N-Sulfonated derivatives of (2-furoyl)piperazine: Promising antibacterial agents with mild cytotoxicity
title_short N-Sulfonated derivatives of (2-furoyl)piperazine: Promising antibacterial agents with mild cytotoxicity
title_full N-Sulfonated derivatives of (2-furoyl)piperazine: Promising antibacterial agents with mild cytotoxicity
title_fullStr N-Sulfonated derivatives of (2-furoyl)piperazine: Promising antibacterial agents with mild cytotoxicity
title_full_unstemmed N-Sulfonated derivatives of (2-furoyl)piperazine: Promising antibacterial agents with mild cytotoxicity
title_sort N-Sulfonated derivatives of (2-furoyl)piperazine: Promising antibacterial agents with mild cytotoxicity
publishDate 2022
container_title Pakistan Journal of Pharmaceutical Sciences
container_volume 35
container_issue 2
doi_str_mv 10.36721/PJPS.2022.35.2.REG.579-585.1
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85129082085&doi=10.36721%2fPJPS.2022.35.2.REG.579-585.1&partnerID=40&md5=74e3ec50e089893dfa55a5cc8fc0dfa0
description 2-Furoyl-1-piperazine (1) was treated with a series of alkyl/aryl sulfonyl chlorides (2a-i) under benignant conditions to obtain its N-sulfonated derivatives (3a-i). These compounds were screened for their antibacterial potential against pathogenic bacteria. The low Minimum Inhibitory Concentration (MIC) values of these molecules, in comparison of ciprofloxacin, demonstrated their high antibacterial potential. Cytotoxic activities were ascertained through their hemolytic potential and mild hemolytic profiles of these compounds proved them to be promising compounds for drug designing and development. © 2022 Pakistan Journal of Pharmaceutical Sciences. All rights reserved.
publisher Pakistan Journal of Pharmaceutical Sciences
issn 1011601X
language English
format Article
accesstype
record_format scopus
collection Scopus
_version_ 1809677594432372736

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