The indigenous populations as the model by nature to understand human genomic-phenomics interactions
Background: The advancement of genomics has progressed in lightning speed over the past two decades. Numerous large-scale genome sequencing initiatives were announced, along with the rise of the holistic precision medicine approach. However, the field of genomic medicine has now come to a bottleneck...
| Published in: | Quantitative Biology |
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| Main Author: | |
| Format: | Review |
| Language: | English |
| Published: |
Higher Education Press Limited Company
2022
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85128206534&doi=10.15302%2fJ-QB-021-0251&partnerID=40&md5=ddd6b75bb58077db5f09c2af6ea220b5 |
| Summary: | Background: The advancement of genomics has progressed in lightning speed over the past two decades. Numerous large-scale genome sequencing initiatives were announced, along with the rise of the holistic precision medicine approach. However, the field of genomic medicine has now come to a bottleneck since genomic-phenomic interactions are not fully comprehended due to the complexity of the human systems biology and environmental influence, hence the emergence of human phenomics. Results: This review attempts to provide an overview of the potential advantages of investigating the human phenomics of indigenous populations and the challenges ahead. Conclusion: We believe that the indigenous populations serve as an ideal model to excavate our understanding of genomic-environmental-phenomics interactions. © The Author(s) 2021. Published by Higher Education Press. |
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| ISSN: | 20954689 |
| DOI: | 10.15302/J-QB-021-0251 |