High prevalence of undiagnosed impaired glucose tolerance in patients with rheumatoid arthritis

Objectives: Although the risk of diabetes mellitus has been recognised in rheumatoid arthritis, undiagnosed dysglycaemia remained under-reported. The study aimed to determine the prevalence and associated factors of dysglycaemia among patients with rheumatoid arthritis, utilising the oral glucose to...

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Published in:SAGE Open Medicine
Main Author: Eddy Warman N.‘.; Baharuddin H.; Abdul Rahman T.H.; Ismail N.; Ch’Ng S.S.; Rosman A.; Abdul Ghani R.
Format: Article
Language:English
Published: SAGE Publications Ltd 2022
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85127262765&doi=10.1177%2f20503121221088088&partnerID=40&md5=15d9928b3deb09f1283f2f2e1e07da3f
id 2-s2.0-85127262765
spelling 2-s2.0-85127262765
Eddy Warman N.‘.; Baharuddin H.; Abdul Rahman T.H.; Ismail N.; Ch’Ng S.S.; Rosman A.; Abdul Ghani R.
High prevalence of undiagnosed impaired glucose tolerance in patients with rheumatoid arthritis
2022
SAGE Open Medicine
10

10.1177/20503121221088088
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85127262765&doi=10.1177%2f20503121221088088&partnerID=40&md5=15d9928b3deb09f1283f2f2e1e07da3f
Objectives: Although the risk of diabetes mellitus has been recognised in rheumatoid arthritis, undiagnosed dysglycaemia remained under-reported. The study aimed to determine the prevalence and associated factors of dysglycaemia among patients with rheumatoid arthritis, utilising the oral glucose tolerance test. Methods: This cross-sectional study involved patients with rheumatoid arthritis, aged ⩾30 years. Following an oral glucose tolerance test, they were divided into two: dysglycaemia and normoglycaemia. Demographic and laboratory parameters were compared using logistic regression analyses. Results: There were 35.5% (55/155) patients with dysglycaemia (including 25.8% impaired glucose tolerance, 7.1% diabetes mellitus and 1.9% with both impaired fasting glucose and impaired glucose tolerance). Patients with dysglycaemia were heavier (65.5 ± 12.3 versus 60.7 ± 10.6 kg, p = 0.01), had wider waist (89.0 ± 12.5 versus 83.1 ± 9.6 cm, p < 0.01), lower high-density lipoprotein cholesterol (1.4 ± 0.3 versus 1.5 ± 0.4 mmol/L, p = 0.02), higher triglyceride (1.3 (0.9–1.8) versus 0.9 (0.8–1.2) mmol/L, p < 0.01) and intercellular adhesion molecule-1 (361.79 (290.38–481.84) versus 315.92 (251.45–407.93) ng/mL, p = 0.01). History of smoking (odds ratio: 5.70, confidence interval: 1.27–25.7), elevated triglyceride (odds ratio: 2.87, confidence interval: 1.33–6.22) and intercellular adhesion molecule-1 (odds ratio: 1.003, confidence interval: 1.001–1.006) were significantly associated with dysglycaemia. Conclusions: Prevalence of undiagnosed dysglycaemia, particularly impaired glucose tolerance, was high in these patients with rheumatoid arthritis, using a 75-g oral glucose tolerance test, which was not associated with disease activity or corticosteroid use. Those with high triglyceride, history of smoking and elevated intercellular adhesion molecule-1 were the two significant predictors for dysglycaemia in our patients with rheumatoid arthritis. Oral glucose tolerance test could be an important laboratory investigation for dysglycaemia in these high-risk patients. © The Author(s) 2022.
SAGE Publications Ltd
20503121
English
Article
All Open Access; Gold Open Access
author Eddy Warman N.‘.; Baharuddin H.; Abdul Rahman T.H.; Ismail N.; Ch’Ng S.S.; Rosman A.; Abdul Ghani R.
spellingShingle Eddy Warman N.‘.; Baharuddin H.; Abdul Rahman T.H.; Ismail N.; Ch’Ng S.S.; Rosman A.; Abdul Ghani R.
High prevalence of undiagnosed impaired glucose tolerance in patients with rheumatoid arthritis
author_facet Eddy Warman N.‘.; Baharuddin H.; Abdul Rahman T.H.; Ismail N.; Ch’Ng S.S.; Rosman A.; Abdul Ghani R.
author_sort Eddy Warman N.‘.; Baharuddin H.; Abdul Rahman T.H.; Ismail N.; Ch’Ng S.S.; Rosman A.; Abdul Ghani R.
title High prevalence of undiagnosed impaired glucose tolerance in patients with rheumatoid arthritis
title_short High prevalence of undiagnosed impaired glucose tolerance in patients with rheumatoid arthritis
title_full High prevalence of undiagnosed impaired glucose tolerance in patients with rheumatoid arthritis
title_fullStr High prevalence of undiagnosed impaired glucose tolerance in patients with rheumatoid arthritis
title_full_unstemmed High prevalence of undiagnosed impaired glucose tolerance in patients with rheumatoid arthritis
title_sort High prevalence of undiagnosed impaired glucose tolerance in patients with rheumatoid arthritis
publishDate 2022
container_title SAGE Open Medicine
container_volume 10
container_issue
doi_str_mv 10.1177/20503121221088088
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85127262765&doi=10.1177%2f20503121221088088&partnerID=40&md5=15d9928b3deb09f1283f2f2e1e07da3f
description Objectives: Although the risk of diabetes mellitus has been recognised in rheumatoid arthritis, undiagnosed dysglycaemia remained under-reported. The study aimed to determine the prevalence and associated factors of dysglycaemia among patients with rheumatoid arthritis, utilising the oral glucose tolerance test. Methods: This cross-sectional study involved patients with rheumatoid arthritis, aged ⩾30 years. Following an oral glucose tolerance test, they were divided into two: dysglycaemia and normoglycaemia. Demographic and laboratory parameters were compared using logistic regression analyses. Results: There were 35.5% (55/155) patients with dysglycaemia (including 25.8% impaired glucose tolerance, 7.1% diabetes mellitus and 1.9% with both impaired fasting glucose and impaired glucose tolerance). Patients with dysglycaemia were heavier (65.5 ± 12.3 versus 60.7 ± 10.6 kg, p = 0.01), had wider waist (89.0 ± 12.5 versus 83.1 ± 9.6 cm, p < 0.01), lower high-density lipoprotein cholesterol (1.4 ± 0.3 versus 1.5 ± 0.4 mmol/L, p = 0.02), higher triglyceride (1.3 (0.9–1.8) versus 0.9 (0.8–1.2) mmol/L, p < 0.01) and intercellular adhesion molecule-1 (361.79 (290.38–481.84) versus 315.92 (251.45–407.93) ng/mL, p = 0.01). History of smoking (odds ratio: 5.70, confidence interval: 1.27–25.7), elevated triglyceride (odds ratio: 2.87, confidence interval: 1.33–6.22) and intercellular adhesion molecule-1 (odds ratio: 1.003, confidence interval: 1.001–1.006) were significantly associated with dysglycaemia. Conclusions: Prevalence of undiagnosed dysglycaemia, particularly impaired glucose tolerance, was high in these patients with rheumatoid arthritis, using a 75-g oral glucose tolerance test, which was not associated with disease activity or corticosteroid use. Those with high triglyceride, history of smoking and elevated intercellular adhesion molecule-1 were the two significant predictors for dysglycaemia in our patients with rheumatoid arthritis. Oral glucose tolerance test could be an important laboratory investigation for dysglycaemia in these high-risk patients. © The Author(s) 2022.
publisher SAGE Publications Ltd
issn 20503121
language English
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