The Chemical and Pharmacological Properties of Mitragynine and Its Diastereomers: An Insight Review

QR Code

The Chemical and Pharmacological Properties of Mitragynine and Its Diastereomers: An Insight Review

Mitragynine, is a naturally occurring indole alkaloid that can be isolated from the leaves of a psychoactive medicinal plant. Mitragyna speciosa, also known as kratom, is found to possess promising analgesic effects on mediating the opioid receptors such as µ (MOR), δ (DOR), and κ (KOR). This alkalo...

Full description

Bibliographic Details
Published in:	Frontiers in Pharmacology
Main Author:	Karunakaran T.; Ngew K.Z.; Zailan A.A.D.; Mian Jong V.Y.; Abu Bakar M.H.
Format:	Review
Language:	English
Published:	Frontiers Media S.A. 2022
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85126177877&doi=10.3389%2ffphar.2022.805986&partnerID=40&md5=15576f84d75a716be31722be741896ef

Similar Items

The Malaysian genus Calophyllum (Calophyllaceae): a review on its phytochemistry and pharmacological activities
by: Zailan A.A.D.; Karunakaran T.; Abu Bakar M.H.; Mian V.J.Y.
Published: (2022)

Phytochemicals from the Stem Bark of Calophyllum havilandii P. F. Stevens and their Biological Activities
by: Zailan A.A.D.; Karunakaran T.; Santhanam R.; Suriaty Yaakop A.; Mohan S.; Abu Bakar M.H.; Jong Yi Mian V.
Published: (2024)

Chemical constituents from the stem barks of Calophyllum recurvatum PF Stevens and Calophyllum andersonii PF Stevens, and their in-vitro hepatotoxic activity
by: Firouz, et al.
Published: (2024)

Mitragynine and its potential blocking effects on specific cardiac potassium channels
by: Tay Y.L.; Teah Y.F.; Chong Y.M.; Jamil M.F.A.; Kollert S.; Adenan M.I.; Wahab H.A.; Döring F.; Wischmeyer E.; Tan M.L.
Published: (2016)

Chemical constituents from the stem barks of Calophyllum recurvatum P.F. Stevens and Calophyllum andersonii P.F. Stevens, and their in-vitro hepatotoxic activity
by: Firouz N.S.; Karunakaran T.; Mokhtar N.; Santhanam R.; Jong V.Y.M.; Abu Bakar M.H.
Published: (2024)

The inhibitory effects of mitragynine on P-glycoprotein in vitro
by: Rusli N.; Amanah A.; Kaur G.; Adenan M.I.; Sulaiman S.F.; Wahab H.A.; Tan M.L.
Published: (2019)

Corrigendum to " Zingiber zerumbet (L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses"
by: Yob N.J.; Jofrry S.M.; Affandi M.M.R.M.M.; Teh L.K.; Salleh M.Z.; Zakaria Z.A.
Published: (2016)

Phytochemicals from Calophyllum macrocarpum Hook.f. and its cytotoxic activities
by: Karunakaran T.; Firouz N.S.; Santhanam R.; Jong V.Y.M.
Published: (2020)

Melastoma malabathricum (L.) smith ethnomedicinal uses, chemical constituents, and pharmacological properties: A review
by: Joffry S.M.; Yob N.J.; Rofiee M.S.; Affandi M.M.R.M.M.; Suhaili Z.; Othman F.; Akim A.M.; Desa M.N.M.; Zakaria Z.A.
Published: (2012)

Phenolics and triterpenoids from stem bark of Calophyllum lanigerum var. austrocoriaceum (Whitmore) P. F. Stevens and their cytotoxic activities
by: Mokhtar N.; Karunakaran T.; Santhanam R.; Abu Bakar M.H.; Jong V.Y.M.
Published: (2024)

Molecular docking studies and in-vitro cholinesterase inhibitory activities of chemical constituents of Calophyllum gracilentum
by: Seruji N.M.U.; Jong V.Y.M.; Karunakaran T.; Zamakshshari N.H.; Mah S.H.; Gunter N.V.; Lizazman M.A.; Masayoshi A.
Published: (2024)

Repurposing Mitragynine as Anti-SARS-CoV-2 Agent Evidenced by In Silico Predictive Approach
by: Tap F.M.; Zakaria N.H.; Majid F.A.A.; Huq A.K.M.M.; Jamal J.A.
Published: (2022)

Traditional Uses and Pharmacological Properties of Anastatica hierochuntica
by: Rostan, et al.
Published: (2024)

Pharmacological properties of Centella asiatica hydrogel in accelerating wound healing in rabbits
by: Sh Ahmed A.; Taher M.; Mandal U.K.; Jaffri J.M.; Susanti D.; Mahmood S.; Zakaria Z.A.
Published: (2019)

Effect of Co-application of Vetiver Grass Biochar and NPK Fertilizer on the Growth of Oil Palm (Elaeis guineensis Jacq.) Seedlings and Soil Chemical Properties
by: Aleiadeh H.; Idris J.; Mohidin H.; Omar L.; Man S.; Munir S.; Jong V.
Published: (2024)

Pharmacology evaluation of Litsea garciae (Lauraceae)
by: Kutoi C.J.; Yen K.H.; Seruji N.M.U.
Published: (2012)

A new pyranoxanthone from Garcinia nervosa
by: Wong K.W.; Ee G.C.L.; Ismail I.S.; Karunakaran T.; Jong V.Y.M.
Published: (2017)

Antioxidant Potential of Calophyllum gracilentum: A Study on Total Phenolic Content, Total Flavonoid Content, and Free Radical Scavenging Activities
by: Seruji N.M.U.; Mian V.J.Y.; Zamakshari N.H.; Karunakaran T.; Koo L.F.; Jin W.T.; Huat C.T.
Published: (2023)

Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl.
by: Daud S.; Karunakaran T.; Santhanam R.; Nagaratnam S.R.; Jong V.Y.M.; Ee G.C.L.
Published: (2021)

Insight into the structural, chemical, optical and conductivities of (C6H10N2)PbBr2I2 mixed-halide hybrid perovskite produced entirely in ambient air condition
by: Ramli A.; Izhan Nawawi Wan Ismail W.; Nazari Abu Bakar M.; Malik Marwan Ali A.; Sepeai S.
Published: (2022)

Weaving the non-pharmacological Alzheimer’s disease therapy into mobile personalized digital memory book application
by: Abu Hashim-de Vries A.H.; Ismail M.; Mohamed A.; Subramaniam P.
Published: (2018)

Isolated Magnetic Dipole MIMO Antenna Linear Arrangement Port Orientation for Wireless Application
by: Amri Safiai M.S.; Bin Aris A.; Kai Loung V.Y.
Published: (2022)

Pharmacological Activities of Dioscorea spp.: A Narrative Review
by: Jamaludin N.N.; Mokhtar A.; Jamil N.F.M.; Muhammad H.; Saad W.M.M.
Published: (2023)

Effects of non-pharmacological interventions on gut microbiota and intestinal permeability in older adults: A systematic review: Non-pharmacological interventions on gut microbiota/barrier
by: Hairul Hisham H.I.; Lim S.M.; Neoh C.F.; Abdul Majeed A.B.; Shahar S.; Ramasamy K.
Published: (2025)

Uncovering anti-inflammatory potential of Lantana camara Linn: Network pharmacology and in vitro studies
by: Khairan K.; Maulydia N.B.; Faddillah V.; Tallei T.E.; Fauzi F.M.; Idroes R.
Published: (2024)

A new coumarin from stem bark of Mesua hexapetala
by: Karunakaran T.; Ee G.C.L.; Teh S.S.; Daud S.; Mah S.H.; Lim C.K.; Jong V.Y.M.; Awang K.
Published: (2016)

ZINGIBER ZERUMBET: PHARMACOLOGICAL VALUES OF ZERUMBONE AND THE EXTRACTION TECHNOLOGY EVOLUTION
by: Ahmad N.U.; Nordin M.F.M.; Mokhtar N.; Wahab I.M.A.; Mohamad M.; Liong T.K.; Amir S.N.K.M.
Published: (2023)

General Health Benefits and Pharmacological Activities of Triticum aestivum L.
by: Moshawih S.; Abdullah Juperi R.N.A.; Paneerselvam G.S.; Ming L.C.; Liew K.B.; Goh B.H.; Al-Worafi Y.M.; Choo C.-Y.; Thuraisingam S.; Goh H.P.; Kifli N.
Published: (2022)

Synthesis and biological evaluation of heterocyclic 1,2,4-triazole scaffolds as promising pharmacological agents
by: Kumari M.; Tahlan S.; Narasimhan B.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Kakkar S.
Published: (2021)

Synthesis, characterization and antimicrobial properties of copper(II) complex of heterocyclic ligands; [Sintesis, pencirian dan ciri antimikrob kuprum(II) kompleks dengan ligan heterosiklik]
by: Ni R.; Mohamadin M.I.; Mian V.J.Y.
Published: (2017)

5,8-Dihydroxy-2,2-dimethyl-12-(3-methylbut-2-enyl)pyrano[3,2-b]xanthen-6-one (brasixanthone B)
by: Binti Seruji N.M.U.; Rosli M.M.; Jong V.Y.M.; Karunakaran T.; Lizazman M.A.; Marlina A.; Binti Halid Y.Y.
Published: (2023)

Antibacterial activity of Garcinia spp. by molecular docking simulations: an overview
by: Zaine, et al.
Published: (2024)

A Brief Review on the Phytochemistry and Pharmacological Activities of Morinda citrifolia L.
by: Ibrahim S.N.; Haron N.; Abdullah A.; Sam M.F.R.
Published: (2024)

The Traditional Uses, Phytochemistry, and Pharmacological Effects of Clitoria ternatea: A Review
by: Ashraf K.; Adlin N.F.; Basri A.N.; Ahmad W.; Sultan S.
Published: (2024)

Exploration of non-pharmacological interventions in the management of behavioural and psychological symptoms of dementia
by: Md Hussin N.S.; Karuppannan M.; Gopalan Y.; Tan K.M.; Gnanasan S.
Published: (2023)

Salacca zalacca: A short review of the palm botany, pharmacological uses and phytochemistry
by: Saleh M.S.M.; Siddiqui M.J.; Mediani A.; Ismail N.H.; Ahmed Q.U.; So'ad S.Z.M.; Saidi-Besbes S.
Published: (2018)

Non-pharmacological interventions for bone health after stroke: A systematic review
by: Sallehuddin H.; Ong T.; Said S.Md.; Tarmizi N.A.A.; Loh S.P.; Lim W.C.; Nadarajah R.; Lim H.T.; Zambri N.H.M.; Ho Y.Y.; Ghazali S.S.
Published: (2022)

Students' perceptions about learning pharmacology at a single private institute in Malaysia
by: Abdulghani M.A.M.; Al-Naggar R.A.
Published: (2015)

Pharmacological and interventional treatment of benign prostatic obstruction: An evidence-based comparative review
by: Malde S.; Lam W.; Adwin Z.; Hashim H.
Published: (2021)

Mitragynine, an euphoric compound inhibits hERG1a/1b channel current and upregulates the complexation of hERG1a-Hsp90 in HEK293-hERG1a/1b cells
by: Tay Y.L.; Amanah A.; Adenan M.I.; Wahab H.A.; Tan M.L.
Published: (2019)