Association between prehospital fluid resuscitation with crystalloids and outcome of trauma patients in Asia by a cross-national multicenter cohort study

Association between prehospital fluid resuscitation with crystalloids and outcome of trauma patients in Asia by a cross-national multicenter cohort study

Prehospital fluid resuscitation with crystalloids in patients following trauma remain controversial. This study aimed to investigate the association between prehospital fluid resuscitation and outcomes of trauma patients in Asia. We conducted a retrospective cohort study of trauma patients between 2...

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Published in:Scientific Reports
Main Author: Sung C.-W.; Sun J.-T.; Huang E.P.-C.; Shin S.D.; Song K.J.; Hong K.J.; Jamaluddin S.F.; Son D.N.; Hsieh M.-J.; Ma M.H.-M.; Hsu L.-M.; Chiang W.-C.; Rao R.; Abraham G.P.; Ramakrishnan T.V.; Jamaluddin S.F.; Mohidin M.A.B.; Saim A.-H.; Kean L.C.; Anthonysamy C.; Yssof S.J.D.M.; Ji K.W.; Kheng C.P.; Ali S.B.M.; Ramanathan P.; Yang C.B.; Chia H.W.; Hamad H.B.; Ismail S.A.; Abdullah W.R.B.W.; Tanaka H.; Kimura A.; Velasco B.; Gundran C.D.; Convocar P.; Sabarre N.G.; Tiglao P.J.; Song K.J.; Jeong J.; Moon S.W.; Kim J.-Y.; Cha W.C.; Lee S.C.; Ahn J.Y.; Lee K.H.; Yeom S.R.; Ryu H.H.; Kim S.J.; Kim S.C.; Hu R.-H.; Wang R.-F.; Hsieh S.-L.; Kao W.-F.; Riyapan S.; Tianwibool P.; Buaprasert P.; Akaraborworn O.; Sakaf O.A.A.; Fares S.; Huy L.B.; Van Dai N.
Format: Article
Language:English
Published: Nature Research 2022
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85126079644&doi=10.1038%2fs41598-022-06933-x&partnerID=40&md5=645d67fa83540f8d9949e0309686a93d
id 2-s2.0-85126079644
spelling 2-s2.0-85126079644
Sung C.-W.; Sun J.-T.; Huang E.P.-C.; Shin S.D.; Song K.J.; Hong K.J.; Jamaluddin S.F.; Son D.N.; Hsieh M.-J.; Ma M.H.-M.; Hsu L.-M.; Chiang W.-C.; Rao R.; Abraham G.P.; Ramakrishnan T.V.; Jamaluddin S.F.; Mohidin M.A.B.; Saim A.-H.; Kean L.C.; Anthonysamy C.; Yssof S.J.D.M.; Ji K.W.; Kheng C.P.; Ali S.B.M.; Ramanathan P.; Yang C.B.; Chia H.W.; Hamad H.B.; Ismail S.A.; Abdullah W.R.B.W.; Tanaka H.; Kimura A.; Velasco B.; Gundran C.D.; Convocar P.; Sabarre N.G.; Tiglao P.J.; Song K.J.; Jeong J.; Moon S.W.; Kim J.-Y.; Cha W.C.; Lee S.C.; Ahn J.Y.; Lee K.H.; Yeom S.R.; Ryu H.H.; Kim S.J.; Kim S.C.; Hu R.-H.; Wang R.-F.; Hsieh S.-L.; Kao W.-F.; Riyapan S.; Tianwibool P.; Buaprasert P.; Akaraborworn O.; Sakaf O.A.A.; Fares S.; Huy L.B.; Van Dai N.
Association between prehospital fluid resuscitation with crystalloids and outcome of trauma patients in Asia by a cross-national multicenter cohort study
2022
Scientific Reports
12
1
10.1038/s41598-022-06933-x
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85126079644&doi=10.1038%2fs41598-022-06933-x&partnerID=40&md5=645d67fa83540f8d9949e0309686a93d
Prehospital fluid resuscitation with crystalloids in patients following trauma remain controversial. This study aimed to investigate the association between prehospital fluid resuscitation and outcomes of trauma patients in Asia. We conducted a retrospective cohort study of trauma patients between 2016 and 2018 using data from the Pan-Asia Trauma Outcomes Study (PATOS) database. Prehospital fluid resuscitation was defined as any administration of intravenous crystalloid fluid on the ambulance before arrival to hospitals. The outcomes were in-hospital mortality and poor functional outcomes, defined as Modified Rankin Scale ≥ 4. Propensity score matching (PSM) was used to equalize potential prognostic factors in both groups. This study included 31,735 patients from six countries in Asia, and 4318 (13.6%) patients had ever received prehospital fluid resuscitation. The patients receiving prehospital fluid resuscitation had a higher risk of in-hospital mortality, with an adjusted odds ratio (aOR) of 2.02, 95% confidence interval (CI) 1.32–3.10, p = 0.001 in PSM analysis. Prehospital fluid resuscitation was also associated with poor functional outcomes, with an OR 1.73, 95% CI: 1.48–2.03, p < 0.001 in PSM analysis. Prehospital fluid resuscitation in patients with major trauma (injury severity score ≥ 16) presented a higher risk of poor functional outcomes (aOR = 2.65, 95% CI: 1.89–3.73 in PSM analysis, pinteraction = 0.006) via subgroup analysis. Prehospital fluid resuscitation of trauma patients is associated with higher in-hospital mortality and poor functional outcomes in the subgroup in countries studied. © 2022, The Author(s).
Nature Research
20452322
English
Article
All Open Access; Gold Open Access
author Sung C.-W.; Sun J.-T.; Huang E.P.-C.; Shin S.D.; Song K.J.; Hong K.J.; Jamaluddin S.F.; Son D.N.; Hsieh M.-J.; Ma M.H.-M.; Hsu L.-M.; Chiang W.-C.; Rao R.; Abraham G.P.; Ramakrishnan T.V.; Jamaluddin S.F.; Mohidin M.A.B.; Saim A.-H.; Kean L.C.; Anthonysamy C.; Yssof S.J.D.M.; Ji K.W.; Kheng C.P.; Ali S.B.M.; Ramanathan P.; Yang C.B.; Chia H.W.; Hamad H.B.; Ismail S.A.; Abdullah W.R.B.W.; Tanaka H.; Kimura A.; Velasco B.; Gundran C.D.; Convocar P.; Sabarre N.G.; Tiglao P.J.; Song K.J.; Jeong J.; Moon S.W.; Kim J.-Y.; Cha W.C.; Lee S.C.; Ahn J.Y.; Lee K.H.; Yeom S.R.; Ryu H.H.; Kim S.J.; Kim S.C.; Hu R.-H.; Wang R.-F.; Hsieh S.-L.; Kao W.-F.; Riyapan S.; Tianwibool P.; Buaprasert P.; Akaraborworn O.; Sakaf O.A.A.; Fares S.; Huy L.B.; Van Dai N.
spellingShingle Sung C.-W.; Sun J.-T.; Huang E.P.-C.; Shin S.D.; Song K.J.; Hong K.J.; Jamaluddin S.F.; Son D.N.; Hsieh M.-J.; Ma M.H.-M.; Hsu L.-M.; Chiang W.-C.; Rao R.; Abraham G.P.; Ramakrishnan T.V.; Jamaluddin S.F.; Mohidin M.A.B.; Saim A.-H.; Kean L.C.; Anthonysamy C.; Yssof S.J.D.M.; Ji K.W.; Kheng C.P.; Ali S.B.M.; Ramanathan P.; Yang C.B.; Chia H.W.; Hamad H.B.; Ismail S.A.; Abdullah W.R.B.W.; Tanaka H.; Kimura A.; Velasco B.; Gundran C.D.; Convocar P.; Sabarre N.G.; Tiglao P.J.; Song K.J.; Jeong J.; Moon S.W.; Kim J.-Y.; Cha W.C.; Lee S.C.; Ahn J.Y.; Lee K.H.; Yeom S.R.; Ryu H.H.; Kim S.J.; Kim S.C.; Hu R.-H.; Wang R.-F.; Hsieh S.-L.; Kao W.-F.; Riyapan S.; Tianwibool P.; Buaprasert P.; Akaraborworn O.; Sakaf O.A.A.; Fares S.; Huy L.B.; Van Dai N.
Association between prehospital fluid resuscitation with crystalloids and outcome of trauma patients in Asia by a cross-national multicenter cohort study
author_facet Sung C.-W.; Sun J.-T.; Huang E.P.-C.; Shin S.D.; Song K.J.; Hong K.J.; Jamaluddin S.F.; Son D.N.; Hsieh M.-J.; Ma M.H.-M.; Hsu L.-M.; Chiang W.-C.; Rao R.; Abraham G.P.; Ramakrishnan T.V.; Jamaluddin S.F.; Mohidin M.A.B.; Saim A.-H.; Kean L.C.; Anthonysamy C.; Yssof S.J.D.M.; Ji K.W.; Kheng C.P.; Ali S.B.M.; Ramanathan P.; Yang C.B.; Chia H.W.; Hamad H.B.; Ismail S.A.; Abdullah W.R.B.W.; Tanaka H.; Kimura A.; Velasco B.; Gundran C.D.; Convocar P.; Sabarre N.G.; Tiglao P.J.; Song K.J.; Jeong J.; Moon S.W.; Kim J.-Y.; Cha W.C.; Lee S.C.; Ahn J.Y.; Lee K.H.; Yeom S.R.; Ryu H.H.; Kim S.J.; Kim S.C.; Hu R.-H.; Wang R.-F.; Hsieh S.-L.; Kao W.-F.; Riyapan S.; Tianwibool P.; Buaprasert P.; Akaraborworn O.; Sakaf O.A.A.; Fares S.; Huy L.B.; Van Dai N.
author_sort Sung C.-W.; Sun J.-T.; Huang E.P.-C.; Shin S.D.; Song K.J.; Hong K.J.; Jamaluddin S.F.; Son D.N.; Hsieh M.-J.; Ma M.H.-M.; Hsu L.-M.; Chiang W.-C.; Rao R.; Abraham G.P.; Ramakrishnan T.V.; Jamaluddin S.F.; Mohidin M.A.B.; Saim A.-H.; Kean L.C.; Anthonysamy C.; Yssof S.J.D.M.; Ji K.W.; Kheng C.P.; Ali S.B.M.; Ramanathan P.; Yang C.B.; Chia H.W.; Hamad H.B.; Ismail S.A.; Abdullah W.R.B.W.; Tanaka H.; Kimura A.; Velasco B.; Gundran C.D.; Convocar P.; Sabarre N.G.; Tiglao P.J.; Song K.J.; Jeong J.; Moon S.W.; Kim J.-Y.; Cha W.C.; Lee S.C.; Ahn J.Y.; Lee K.H.; Yeom S.R.; Ryu H.H.; Kim S.J.; Kim S.C.; Hu R.-H.; Wang R.-F.; Hsieh S.-L.; Kao W.-F.; Riyapan S.; Tianwibool P.; Buaprasert P.; Akaraborworn O.; Sakaf O.A.A.; Fares S.; Huy L.B.; Van Dai N.
title Association between prehospital fluid resuscitation with crystalloids and outcome of trauma patients in Asia by a cross-national multicenter cohort study
title_short Association between prehospital fluid resuscitation with crystalloids and outcome of trauma patients in Asia by a cross-national multicenter cohort study
title_full Association between prehospital fluid resuscitation with crystalloids and outcome of trauma patients in Asia by a cross-national multicenter cohort study
title_fullStr Association between prehospital fluid resuscitation with crystalloids and outcome of trauma patients in Asia by a cross-national multicenter cohort study
title_full_unstemmed Association between prehospital fluid resuscitation with crystalloids and outcome of trauma patients in Asia by a cross-national multicenter cohort study
title_sort Association between prehospital fluid resuscitation with crystalloids and outcome of trauma patients in Asia by a cross-national multicenter cohort study
publishDate 2022
container_title Scientific Reports
container_volume 12
container_issue 1
doi_str_mv 10.1038/s41598-022-06933-x
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85126079644&doi=10.1038%2fs41598-022-06933-x&partnerID=40&md5=645d67fa83540f8d9949e0309686a93d
description Prehospital fluid resuscitation with crystalloids in patients following trauma remain controversial. This study aimed to investigate the association between prehospital fluid resuscitation and outcomes of trauma patients in Asia. We conducted a retrospective cohort study of trauma patients between 2016 and 2018 using data from the Pan-Asia Trauma Outcomes Study (PATOS) database. Prehospital fluid resuscitation was defined as any administration of intravenous crystalloid fluid on the ambulance before arrival to hospitals. The outcomes were in-hospital mortality and poor functional outcomes, defined as Modified Rankin Scale ≥ 4. Propensity score matching (PSM) was used to equalize potential prognostic factors in both groups. This study included 31,735 patients from six countries in Asia, and 4318 (13.6%) patients had ever received prehospital fluid resuscitation. The patients receiving prehospital fluid resuscitation had a higher risk of in-hospital mortality, with an adjusted odds ratio (aOR) of 2.02, 95% confidence interval (CI) 1.32–3.10, p = 0.001 in PSM analysis. Prehospital fluid resuscitation was also associated with poor functional outcomes, with an OR 1.73, 95% CI: 1.48–2.03, p < 0.001 in PSM analysis. Prehospital fluid resuscitation in patients with major trauma (injury severity score ≥ 16) presented a higher risk of poor functional outcomes (aOR = 2.65, 95% CI: 1.89–3.73 in PSM analysis, pinteraction = 0.006) via subgroup analysis. Prehospital fluid resuscitation of trauma patients is associated with higher in-hospital mortality and poor functional outcomes in the subgroup in countries studied. © 2022, The Author(s).
publisher Nature Research
issn 20452322
language English
format Article
accesstype All Open Access; Gold Open Access
record_format scopus
collection Scopus
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