| Summary: | Hyperthermia treatment is an alternative treatment that can be considered in breast cancer. This treatment uses Electromagnetic waves as a source of heat to destroy cell cancer. The main challenge for this treatment is the focusing capability and the existence of a wide area of unwanted hotspots at the surrounding healthy cell. Therefore, in this paper, the desired penetration depth and focus position distance are obtained and compared with different frequencies and substrates. The desired penetration depth and focus position distance are basically determined from the statistical analysis of real mammogram breast cancer images. The simulation with SEMCAD X is then conducted to select the best operating frequency and substrate to achieve the great penetration depth and focus position distance on the treated tissue. Based on the results, the different operating frequencies with different substrates have provided different penetration depth and focus position distance. The unwanted hotspot areas are also different. In conjunction with that, further research needs to be carried out in order to obtain the best operating frequency with the most suitable substrate to be used thatmay attain the required results on the treated tissue, mainly when different cancer depths and focus position distances are concerned. © 2021 IEEE.
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