Deciphering Synsepalum dulcificum as an Arising Phytotherapy Agent: Background, Phytochemical and Pharmacological Properties with Associated Molecular Mechanisms; [Mentafsir Synsepalum dulcificum sebagai Agen Fitoterapi yang semakin Meningkat: Latar Belakang, Sifat Fitokimia dan Farmakologi dengan Mekanisme Molekul Berkaitan]

• Published in: Sains Malaysiana
• Main Author: Ee J.W.; Velaga A.; Guad R.M.; Subramaniyan V.; Fuloria N.K.; Fuloria S.; Choy K.W.; Wu Y.S.
• Format: Article
• Language: English
• Published: Penerbit Universiti Kebangsaan Malaysia 2022
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124655535&doi=10.17576%2fjsm-2022-5101-16&partnerID=40&md5=5aa176a8b78d98089439218856ea538a

Medicinal plants with less side effects are paramount important for humankind to cure various ailments as compared to newly developed allopathic medicines. Synsepalum dulcificum Daniell (Sapotaceae), is well known as miracle fruits due to its distinctive taste-modifying property. This review aimed to discuss its recent reported pharmacological properties and associated molecular mechanisms as a novel phytotherapy agent. In addition, background, phytochemical analysis and toxicological studies were also discussed as the foundation and added values for this review. It was discovered that S. dulcificum is endowed with various classes of phytochemicals, such as flavonoids, tannins, alkaloids and saponins. This review ravelled that S. dulcificum is a potent medicinal plant associated with antioxidant, antidiabetic, antimicrobial, anticancer, anti-hyperuricemic, hepatoprotective, anti-hyperlipidaemic, and anticonvulsant activities, with less toxicity shown. Future research may explore further the corresponding phytochemicals, associated molecular mechanisms, toxicological and pharmacokinetic profile before subjecting to clinical testing. © 2022 Penerbit Universiti Kebangsaan Malaysia. All rights reserved.