Serum and Saliva 25(OH)D Levels in Relation to Dental Caries in Young Children

Objective: Several studies have reported that low levels of vitamin D (25(OH)D) are associated with an increased risk of dental caries and that optimal levels may offer protection. This study aimed to assess the relationship between serum and saliva 25(OH)D levels and caries among young children. St...

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Published in:Journal of Clinical Pediatric Dentistry
Main Author: Hussein A.S.; Almoudi M.M.; Abu-Hassan M.I.; Schroth R.J.; Saripudin B.; Mohamad M.S.F.
Format: Article
Language:English
Published: MRE Press 2021
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123269366&doi=10.17796%2f1053-4625-45.6.8&partnerID=40&md5=69f50508b72a4df0638e41d6cff9162e
id 2-s2.0-85123269366
spelling 2-s2.0-85123269366
Hussein A.S.; Almoudi M.M.; Abu-Hassan M.I.; Schroth R.J.; Saripudin B.; Mohamad M.S.F.
Serum and Saliva 25(OH)D Levels in Relation to Dental Caries in Young Children
2021
Journal of Clinical Pediatric Dentistry
45
6
10.17796/1053-4625-45.6.8
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123269366&doi=10.17796%2f1053-4625-45.6.8&partnerID=40&md5=69f50508b72a4df0638e41d6cff9162e
Objective: Several studies have reported that low levels of vitamin D (25(OH)D) are associated with an increased risk of dental caries and that optimal levels may offer protection. This study aimed to assess the relationship between serum and saliva 25(OH)D levels and caries among young children. Study design: A total of 120 healthy children were recruited; 93 with caries and 27 caries-free. Dental caries status was evaluated using decayed, missing and filled in primary teeth (dmft) index. Blood and unstimulated whole saliva samples were collected. Laboratory analysis was performed using Enzyme-Linked Immunosorbent Assay Kit. Data were analyzed with descriptive statistics, bivariate and Spearman’s rank correlation analysis. Results: There were no significant associations between serum and saliva 25(OH)D levels and caries status (P > 0.05). Levels of 25(OH)D in serum were significantly higher than levels found in saliva (P < 0.05), and a correlation between serum and saliva 25(OH)D levels was observed (P < 0.05). Conclusions: The association between serum and saliva 25(OH)D and dental caries in young children was inconclusive. However, a positive and significant correlation was observed between serum and saliva 25(OH)D levels. Further studies are warranted to investigate the definite relation between 25(OH)D levels and dental caries and using saliva 25(OH)D as a non-invasive alternative method over blood samples. © 2021, MRE Press. All rights reserved.
MRE Press
10534628
English
Article

author Hussein A.S.; Almoudi M.M.; Abu-Hassan M.I.; Schroth R.J.; Saripudin B.; Mohamad M.S.F.
spellingShingle Hussein A.S.; Almoudi M.M.; Abu-Hassan M.I.; Schroth R.J.; Saripudin B.; Mohamad M.S.F.
Serum and Saliva 25(OH)D Levels in Relation to Dental Caries in Young Children
author_facet Hussein A.S.; Almoudi M.M.; Abu-Hassan M.I.; Schroth R.J.; Saripudin B.; Mohamad M.S.F.
author_sort Hussein A.S.; Almoudi M.M.; Abu-Hassan M.I.; Schroth R.J.; Saripudin B.; Mohamad M.S.F.
title Serum and Saliva 25(OH)D Levels in Relation to Dental Caries in Young Children
title_short Serum and Saliva 25(OH)D Levels in Relation to Dental Caries in Young Children
title_full Serum and Saliva 25(OH)D Levels in Relation to Dental Caries in Young Children
title_fullStr Serum and Saliva 25(OH)D Levels in Relation to Dental Caries in Young Children
title_full_unstemmed Serum and Saliva 25(OH)D Levels in Relation to Dental Caries in Young Children
title_sort Serum and Saliva 25(OH)D Levels in Relation to Dental Caries in Young Children
publishDate 2021
container_title Journal of Clinical Pediatric Dentistry
container_volume 45
container_issue 6
doi_str_mv 10.17796/1053-4625-45.6.8
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123269366&doi=10.17796%2f1053-4625-45.6.8&partnerID=40&md5=69f50508b72a4df0638e41d6cff9162e
description Objective: Several studies have reported that low levels of vitamin D (25(OH)D) are associated with an increased risk of dental caries and that optimal levels may offer protection. This study aimed to assess the relationship between serum and saliva 25(OH)D levels and caries among young children. Study design: A total of 120 healthy children were recruited; 93 with caries and 27 caries-free. Dental caries status was evaluated using decayed, missing and filled in primary teeth (dmft) index. Blood and unstimulated whole saliva samples were collected. Laboratory analysis was performed using Enzyme-Linked Immunosorbent Assay Kit. Data were analyzed with descriptive statistics, bivariate and Spearman’s rank correlation analysis. Results: There were no significant associations between serum and saliva 25(OH)D levels and caries status (P > 0.05). Levels of 25(OH)D in serum were significantly higher than levels found in saliva (P < 0.05), and a correlation between serum and saliva 25(OH)D levels was observed (P < 0.05). Conclusions: The association between serum and saliva 25(OH)D and dental caries in young children was inconclusive. However, a positive and significant correlation was observed between serum and saliva 25(OH)D levels. Further studies are warranted to investigate the definite relation between 25(OH)D levels and dental caries and using saliva 25(OH)D as a non-invasive alternative method over blood samples. © 2021, MRE Press. All rights reserved.
publisher MRE Press
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