Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices

Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices

Antisperm antibodies (ASA), as a cause of male infertility, have been detected in infertile males as early as 1954. Multiple causes of ASA production have been identified, and they are due to an abnormal exposure of mature germ cells to the immune system. ASA testing (with mixed anti-globulin reacti...

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Published in:World Journal of Men's Health
Main Author: Gupta S.; Sharma R.; Agarwal A.; Boitrelle F.; Finelli R.; Farkouh A.; Saleh R.; Abdel-Meguid T.A.-A.; Gül M.; Zilaitiene B.; Ko E.; Rambhatla A.; Zini A.; Leisegang K.; Kuroda S.; Henkel R.; Cannarella R.; Palani A.; Cho C.-L.; Ho C.C.K.; Zylbersztejn D.S.; Pescatori E.; Chung E.; Dimitriadis F.; Pinggera G.-M.; Busetto G.M.; Balercia G.; Salvio G.; Colpi G.M.; Çeker G.; Taniguchi H.; Kandil H.; Park H.J.; Rosas I.M.; de la Rosette J.; Cardoso J.P.G.; Ramsay J.; Alvarez J.; Molina J.M.C.; Khalafalla K.; Bowa K.; Tremellen K.; Evgeni E.; Rocco L.; Peña M.G.R.; Sabbaghian M.; Martinez M.; Arafa M.; Al-Marhoon M.S.; Tadros N.; Garrido N.; Rajmil O.; Sengupta P.; Vogiatzi P.; Kavoussi P.; Birowo P.; Kosgi R.; Bani-Hani S.; Micic S.; Parekattil S.; Jindal S.; Le T.V.; Mostafa T.; Toprak T.; Morimoto Y.; Malhotra V.; Aghamajidi A.; Durairajanayagam D.; Shah R.
Format: Article
Language:English
Published: Korean Society for Sexual Medicine and Andrology 2022
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122986018&doi=10.5534%2fwjmh.210164&partnerID=40&md5=31d3324b85469551211bd1743c8518da
id 2-s2.0-85122986018
spelling 2-s2.0-85122986018
Gupta S.; Sharma R.; Agarwal A.; Boitrelle F.; Finelli R.; Farkouh A.; Saleh R.; Abdel-Meguid T.A.-A.; Gül M.; Zilaitiene B.; Ko E.; Rambhatla A.; Zini A.; Leisegang K.; Kuroda S.; Henkel R.; Cannarella R.; Palani A.; Cho C.-L.; Ho C.C.K.; Zylbersztejn D.S.; Pescatori E.; Chung E.; Dimitriadis F.; Pinggera G.-M.; Busetto G.M.; Balercia G.; Salvio G.; Colpi G.M.; Çeker G.; Taniguchi H.; Kandil H.; Park H.J.; Rosas I.M.; de la Rosette J.; Cardoso J.P.G.; Ramsay J.; Alvarez J.; Molina J.M.C.; Khalafalla K.; Bowa K.; Tremellen K.; Evgeni E.; Rocco L.; Peña M.G.R.; Sabbaghian M.; Martinez M.; Arafa M.; Al-Marhoon M.S.; Tadros N.; Garrido N.; Rajmil O.; Sengupta P.; Vogiatzi P.; Kavoussi P.; Birowo P.; Kosgi R.; Bani-Hani S.; Micic S.; Parekattil S.; Jindal S.; Le T.V.; Mostafa T.; Toprak T.; Morimoto Y.; Malhotra V.; Aghamajidi A.; Durairajanayagam D.; Shah R.
Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices
2022
World Journal of Men's Health
40
3
10.5534/wjmh.210164
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122986018&doi=10.5534%2fwjmh.210164&partnerID=40&md5=31d3324b85469551211bd1743c8518da
Antisperm antibodies (ASA), as a cause of male infertility, have been detected in infertile males as early as 1954. Multiple causes of ASA production have been identified, and they are due to an abnormal exposure of mature germ cells to the immune system. ASA testing (with mixed anti-globulin reaction, and immunobead binding test) was described in the WHO manual 5th edition and is most recently listed among the extended semen tests in the WHO manual 6th edition. The relationship between ASA and infertility is somewhat complex. The presence of sperm agglutination, while insufficient to diagnose immunological infertility, may indicate the presence of ASA. However, ASA can also be present in the absence of any sperm agglutination. The andrological management of ASA depends on the etiology and individual practices of clinicians. In this article, we provide a comprehensive review of the causes of ASA production, its role in immunological male infertility, clinical indications of ASA testing, and the available therapeutic options. We also provide the details of laboratory procedures for assessment of ASA together with important measures for quality control. Additionally, laboratory and clinical scenarios are presented to guide the reader in the management of ASA and immunological male infertility. Furthermore, we report the results of a recent worldwide survey, conducted to gather information about clinical practices in the management of immunological male infertility. Copyright © 2022 Korean Society for Sexual Medicine and Andrology
Korean Society for Sexual Medicine and Andrology
22874208
English
Article
All Open Access; Gold Open Access
author Gupta S.; Sharma R.; Agarwal A.; Boitrelle F.; Finelli R.; Farkouh A.; Saleh R.; Abdel-Meguid T.A.-A.; Gül M.; Zilaitiene B.; Ko E.; Rambhatla A.; Zini A.; Leisegang K.; Kuroda S.; Henkel R.; Cannarella R.; Palani A.; Cho C.-L.; Ho C.C.K.; Zylbersztejn D.S.; Pescatori E.; Chung E.; Dimitriadis F.; Pinggera G.-M.; Busetto G.M.; Balercia G.; Salvio G.; Colpi G.M.; Çeker G.; Taniguchi H.; Kandil H.; Park H.J.; Rosas I.M.; de la Rosette J.; Cardoso J.P.G.; Ramsay J.; Alvarez J.; Molina J.M.C.; Khalafalla K.; Bowa K.; Tremellen K.; Evgeni E.; Rocco L.; Peña M.G.R.; Sabbaghian M.; Martinez M.; Arafa M.; Al-Marhoon M.S.; Tadros N.; Garrido N.; Rajmil O.; Sengupta P.; Vogiatzi P.; Kavoussi P.; Birowo P.; Kosgi R.; Bani-Hani S.; Micic S.; Parekattil S.; Jindal S.; Le T.V.; Mostafa T.; Toprak T.; Morimoto Y.; Malhotra V.; Aghamajidi A.; Durairajanayagam D.; Shah R.
spellingShingle Gupta S.; Sharma R.; Agarwal A.; Boitrelle F.; Finelli R.; Farkouh A.; Saleh R.; Abdel-Meguid T.A.-A.; Gül M.; Zilaitiene B.; Ko E.; Rambhatla A.; Zini A.; Leisegang K.; Kuroda S.; Henkel R.; Cannarella R.; Palani A.; Cho C.-L.; Ho C.C.K.; Zylbersztejn D.S.; Pescatori E.; Chung E.; Dimitriadis F.; Pinggera G.-M.; Busetto G.M.; Balercia G.; Salvio G.; Colpi G.M.; Çeker G.; Taniguchi H.; Kandil H.; Park H.J.; Rosas I.M.; de la Rosette J.; Cardoso J.P.G.; Ramsay J.; Alvarez J.; Molina J.M.C.; Khalafalla K.; Bowa K.; Tremellen K.; Evgeni E.; Rocco L.; Peña M.G.R.; Sabbaghian M.; Martinez M.; Arafa M.; Al-Marhoon M.S.; Tadros N.; Garrido N.; Rajmil O.; Sengupta P.; Vogiatzi P.; Kavoussi P.; Birowo P.; Kosgi R.; Bani-Hani S.; Micic S.; Parekattil S.; Jindal S.; Le T.V.; Mostafa T.; Toprak T.; Morimoto Y.; Malhotra V.; Aghamajidi A.; Durairajanayagam D.; Shah R.
Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices
author_facet Gupta S.; Sharma R.; Agarwal A.; Boitrelle F.; Finelli R.; Farkouh A.; Saleh R.; Abdel-Meguid T.A.-A.; Gül M.; Zilaitiene B.; Ko E.; Rambhatla A.; Zini A.; Leisegang K.; Kuroda S.; Henkel R.; Cannarella R.; Palani A.; Cho C.-L.; Ho C.C.K.; Zylbersztejn D.S.; Pescatori E.; Chung E.; Dimitriadis F.; Pinggera G.-M.; Busetto G.M.; Balercia G.; Salvio G.; Colpi G.M.; Çeker G.; Taniguchi H.; Kandil H.; Park H.J.; Rosas I.M.; de la Rosette J.; Cardoso J.P.G.; Ramsay J.; Alvarez J.; Molina J.M.C.; Khalafalla K.; Bowa K.; Tremellen K.; Evgeni E.; Rocco L.; Peña M.G.R.; Sabbaghian M.; Martinez M.; Arafa M.; Al-Marhoon M.S.; Tadros N.; Garrido N.; Rajmil O.; Sengupta P.; Vogiatzi P.; Kavoussi P.; Birowo P.; Kosgi R.; Bani-Hani S.; Micic S.; Parekattil S.; Jindal S.; Le T.V.; Mostafa T.; Toprak T.; Morimoto Y.; Malhotra V.; Aghamajidi A.; Durairajanayagam D.; Shah R.
author_sort Gupta S.; Sharma R.; Agarwal A.; Boitrelle F.; Finelli R.; Farkouh A.; Saleh R.; Abdel-Meguid T.A.-A.; Gül M.; Zilaitiene B.; Ko E.; Rambhatla A.; Zini A.; Leisegang K.; Kuroda S.; Henkel R.; Cannarella R.; Palani A.; Cho C.-L.; Ho C.C.K.; Zylbersztejn D.S.; Pescatori E.; Chung E.; Dimitriadis F.; Pinggera G.-M.; Busetto G.M.; Balercia G.; Salvio G.; Colpi G.M.; Çeker G.; Taniguchi H.; Kandil H.; Park H.J.; Rosas I.M.; de la Rosette J.; Cardoso J.P.G.; Ramsay J.; Alvarez J.; Molina J.M.C.; Khalafalla K.; Bowa K.; Tremellen K.; Evgeni E.; Rocco L.; Peña M.G.R.; Sabbaghian M.; Martinez M.; Arafa M.; Al-Marhoon M.S.; Tadros N.; Garrido N.; Rajmil O.; Sengupta P.; Vogiatzi P.; Kavoussi P.; Birowo P.; Kosgi R.; Bani-Hani S.; Micic S.; Parekattil S.; Jindal S.; Le T.V.; Mostafa T.; Toprak T.; Morimoto Y.; Malhotra V.; Aghamajidi A.; Durairajanayagam D.; Shah R.
title Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices
title_short Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices
title_full Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices
title_fullStr Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices
title_full_unstemmed Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices
title_sort Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices
publishDate 2022
container_title World Journal of Men's Health
container_volume 40
container_issue 3
doi_str_mv 10.5534/wjmh.210164
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122986018&doi=10.5534%2fwjmh.210164&partnerID=40&md5=31d3324b85469551211bd1743c8518da
description Antisperm antibodies (ASA), as a cause of male infertility, have been detected in infertile males as early as 1954. Multiple causes of ASA production have been identified, and they are due to an abnormal exposure of mature germ cells to the immune system. ASA testing (with mixed anti-globulin reaction, and immunobead binding test) was described in the WHO manual 5th edition and is most recently listed among the extended semen tests in the WHO manual 6th edition. The relationship between ASA and infertility is somewhat complex. The presence of sperm agglutination, while insufficient to diagnose immunological infertility, may indicate the presence of ASA. However, ASA can also be present in the absence of any sperm agglutination. The andrological management of ASA depends on the etiology and individual practices of clinicians. In this article, we provide a comprehensive review of the causes of ASA production, its role in immunological male infertility, clinical indications of ASA testing, and the available therapeutic options. We also provide the details of laboratory procedures for assessment of ASA together with important measures for quality control. Additionally, laboratory and clinical scenarios are presented to guide the reader in the management of ASA and immunological male infertility. Furthermore, we report the results of a recent worldwide survey, conducted to gather information about clinical practices in the management of immunological male infertility. Copyright © 2022 Korean Society for Sexual Medicine and Andrology
publisher Korean Society for Sexual Medicine and Andrology
issn 22874208
language English
format Article
accesstype All Open Access; Gold Open Access
record_format scopus
collection Scopus
_version_ 1809678480731799552

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