Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices

Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices

Antisperm antibodies (ASA), as a cause of male infertility, have been detected in infertile males as early as 1954. Multiple causes of ASA production have been identified, and they are due to an abnormal exposure of mature germ cells to the immune system. ASA testing (with mixed anti-globulin reacti...

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Bibliographic Details
Published in:World Journal of Men's Health
Main Author: Gupta S.; Sharma R.; Agarwal A.; Boitrelle F.; Finelli R.; Farkouh A.; Saleh R.; Abdel-Meguid T.A.-A.; Gül M.; Zilaitiene B.; Ko E.; Rambhatla A.; Zini A.; Leisegang K.; Kuroda S.; Henkel R.; Cannarella R.; Palani A.; Cho C.-L.; Ho C.C.K.; Zylbersztejn D.S.; Pescatori E.; Chung E.; Dimitriadis F.; Pinggera G.-M.; Busetto G.M.; Balercia G.; Salvio G.; Colpi G.M.; Çeker G.; Taniguchi H.; Kandil H.; Park H.J.; Rosas I.M.; de la Rosette J.; Cardoso J.P.G.; Ramsay J.; Alvarez J.; Molina J.M.C.; Khalafalla K.; Bowa K.; Tremellen K.; Evgeni E.; Rocco L.; Peña M.G.R.; Sabbaghian M.; Martinez M.; Arafa M.; Al-Marhoon M.S.; Tadros N.; Garrido N.; Rajmil O.; Sengupta P.; Vogiatzi P.; Kavoussi P.; Birowo P.; Kosgi R.; Bani-Hani S.; Micic S.; Parekattil S.; Jindal S.; Le T.V.; Mostafa T.; Toprak T.; Morimoto Y.; Malhotra V.; Aghamajidi A.; Durairajanayagam D.; Shah R.
Format: Article
Language:English
Published: Korean Society for Sexual Medicine and Andrology 2022
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122986018&doi=10.5534%2fwjmh.210164&partnerID=40&md5=31d3324b85469551211bd1743c8518da
Description
Summary:Antisperm antibodies (ASA), as a cause of male infertility, have been detected in infertile males as early as 1954. Multiple causes of ASA production have been identified, and they are due to an abnormal exposure of mature germ cells to the immune system. ASA testing (with mixed anti-globulin reaction, and immunobead binding test) was described in the WHO manual 5th edition and is most recently listed among the extended semen tests in the WHO manual 6th edition. The relationship between ASA and infertility is somewhat complex. The presence of sperm agglutination, while insufficient to diagnose immunological infertility, may indicate the presence of ASA. However, ASA can also be present in the absence of any sperm agglutination. The andrological management of ASA depends on the etiology and individual practices of clinicians. In this article, we provide a comprehensive review of the causes of ASA production, its role in immunological male infertility, clinical indications of ASA testing, and the available therapeutic options. We also provide the details of laboratory procedures for assessment of ASA together with important measures for quality control. Additionally, laboratory and clinical scenarios are presented to guide the reader in the management of ASA and immunological male infertility. Furthermore, we report the results of a recent worldwide survey, conducted to gather information about clinical practices in the management of immunological male infertility. Copyright © 2022 Korean Society for Sexual Medicine and Andrology
ISSN:22874208
DOI:10.5534/wjmh.210164

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