Arq ajwain protects nonalcoholic fatty liver disease on high-fat diet-induced obese rat

• Published in: Trends in Phytochemical Research
• Main Author: Haque R.; Ahmad A.; Ashraf K.; Akhter H.; Jameel M.; Ali A.; Akhtar W.; Dhaka M.; Rana K.
• Format: Article
• Language: English
• Published: Islamic Azad University 2021
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121797243&doi=10.30495%2ftpr.2021.1940654.1221&partnerID=40&md5=02d57e6ea92e044c23d28ec0033a634a

In the present study, we investigated the safety and therapeutic efficacy of arq ajwain (AA) against nonalcoholic fatty liver disease (NAFLD) on a high-fat diet (HFD) induced obese rat model. After 4 weeks of the treatment, AA (4 mL/kg, twice a day) and AA1 (7.75 mL/kg, twice a day) treatments reduced body weight, serum triglycerides (TG), total cholesterol (TG), glucose, insulin, leptin, pancreatic lipase activity and alanine aminotransferase (ALT) levels (p < 0.001). AA, AA1, and thymol (T) treatments also decreased lipids (TG and TC) levels and increased thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), and catalase (CAT) levels in hepatic tissue (p < 0.001). Moreover, treatment groups considerably reduced hepatic inflammation, steatosis, hepatocellular ballooning, and fibrosis. These results recommend that arq ajwain has a strong protective effect against NAFLD in HFD induced obese rat models. © 2021 Islamic Azad University, Shahrood Branch Press, All rights reserved.