| Summary: | Leukemogenic effects are probably a major risk in occupational disease related to benzene derivatives exposure among exposed workers. Biological monitoring of benzene and occupational exposure limit (OEL) is an important indicator in assessing exposure and health risk related - occupational disease among workers, through airborne exposure of the permissible exposure limit (PEL) for 8 hours’ time-weighted average (TWA8) at 0.5 ppm or 1 ppm depending on country. The toxicity effect of benzene may occur in humans via inhalation, ingestion, dermal, or eye contact. This paper aimed to review the type of occupational disease related to the toxicity of benzene derivatives exposure in the workplace worldwide. Based on this review, China is the country with the most reported benzene-related occupational diseases from 1948 till 2021 through cohort, case, and cross-sectional studies. © 2021 UPM Press. All rights reserved.
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