Phytochemicals and Bioactivities of Syzygium filiforme var. filiforme; [(Fitokimia dan Bioaktiviti Syzygium filiforme var. filiforme)]

• Published in: Sains Malaysiana
• Main Author: Ahmad M.H.; Izan N.N.; Ismail N.H.; Naz H.
• Format: Article
• Language: English
• Published: Penerbit Universiti Kebangsaan Malaysia 2021
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120642190&doi=10.17576%2fjsm-2021-5011-07&partnerID=40&md5=75e67be1317327020d496d2e10c905be

Syzygium filiforme var. filiforme is a plant variety from dicotyledonous plant family (Myrtaceae). Phytochemical studies on S. filiforme var. filiforme stem bark have successfully isolated and characterized arjunolic acid (1), alphitolic acid (2), betulinic acid (3), ursolic acid (4), ursolic acid 3-methyl ester (5), β-sitosterol (6) and stigmasterol (7). The inhibitory activities against free radical, starch, and bacteria for major compounds were tested by using DPPH, α-glucosidase and minimum inhibitory and bacterial concentration assays, respectively. No promising antioxidant activity was shown on tested samples except methanolic crude extract. For antidiabetic activity, methanolic and dichloromethane crude extracts displayed potent activity compared to 1-deoxynojirimycin. Minimum inhibitory concentration (MIC) and minimum bacterial concentration (MBC) assays for antibacterial activity were evaluated on Escherichia coli, Staphylococcus aureus, and Bacillus subtilis. All crude extracts and major compounds displayed weak and no promising activities for MIC method, respectively. Meanwhile, for MBC method, hexane crude extract and compound 1 showed inhibition against B. subtilis. © 2021 Penerbit Universiti Kebangsaan Malaysia. All rights reserved.