| Summary: | In Malaysia, medicinal plants are widely used daily as a major component of society's restorative therapies. Malaysia's environment is recognized for its wide range of species and a rich source of medicinal herbs. Clidemia capitellata (Bonpl.) D.Don is a shrub belonging to the family of the Melastomataceae locally known as "Senduduk bulu". The current study aims to determine the antibacterial, antioxidant, and chemical profile of Clidemia capitellata (Bonpl.) D.Don leaf extract. Antimicrobial activity was determined by disc diffusion in agar and microdilution in broth (MIC-g/mL). Antioxidant activity was determined using the DPPH free radical capture assay, the presence of phytochemical profile was determined by thin-layer chromatography (TLC), while total phenols (EGA/g) and flavonoids (EQ/g) were quantified using spectrophotometry. The results indicated that the extract of Clidemia capitellata was active against Escherichia coli (ATCC 25922) with a minimum inhibitory concentration (MIC) of 62.5 g/mL. The extract was the most effective at sequestering DPPH free radicals (28.60 1.54 %). Total phenolic contents obtained were 80.78 ±0.06 and total flavonoid contents obtained were 64.64±0.10 of the extract, respectively. The phytochemical profile revealed the presence of condensed tannins, terpenes, steroids, and polyphenols but no alkaloids. As a result of the positive results obtained, it is anticipated that the active component of extracts will continue to be extracted and that new chemical-pharmacological assessments will be conducted in the future. © 2021 Malaysian Society for Biochemistry and Molecular Biology. All rights reserved.
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