The Malaysian genus Calophyllum (Calophyllaceae): a review on its phytochemistry and pharmacological activities

• Published in: Natural Product Research
• Main Author: Zailan A.A.D.; Karunakaran T.; Abu Bakar M.H.; Mian V.J.Y.
• Format: Review
• Language: English
• Published: Taylor and Francis Ltd. 2022
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116804729&doi=10.1080%2f14786419.2021.1982936&partnerID=40&md5=296e96b308d93746306b283759e22cd9

Genus Calophyllum from the family of Calophyllaceae is an evergreen broad-leaved tree that is endemic to Southeast Asia, especially Malaysia. They have been reported for various ethnomedicinal uses in traditional medicine. Previous studies of Malaysian Calophyllum species revealed them to be a rich source of bioactive phytoconstituents such as xanthones, coumarins, terpenoids, and chromanone acids. To date, the extracts and compounds from Malaysian Calophyllum species have shown a broad spectrum of pharmacological activities. For example, calanolide A, a coumarin isolated from Malaysian C. lanigerum, has now reached clinical development to become an anti-HIV drug. This article presents an overview of the significant phytochemical and pharmacological activities of Malaysian Calophyllum species to aid researchers in further discovery of potential benefits of various species of this genus. © 2021 Informa UK Limited, trading as Taylor & Francis Group.