Survey on serum protein electrophoresis and recommendations for standardised reporting

Survey on serum protein electrophoresis and recommendations for standardised reporting

Introduction: Serum protein electrophoresis (SPE) is a well-established laboratory technique. However, reporting of results varies considerably between laboratories. The variation in reporting can cause confusion to the clinician with a potential of adversely impacting patient care. The purpose of t...

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Published in:Malaysian Journal of Pathology
Main Author: Sthaneshwar P.; Thambiah S.C.; Mat Salleh M.J.; Nasuruddin D.N.; Ahmad Zabidi N.F.; Jelani A.M.; Ismail A.M.; Lai L.C.; Gan G.G.
Format: Article
Language:English
Published: Malaysian Society of Pathologists 2021
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114673459&partnerID=40&md5=29de2e632ecb9620b1967088f76fbb4c
id 2-s2.0-85114673459
spelling 2-s2.0-85114673459
Sthaneshwar P.; Thambiah S.C.; Mat Salleh M.J.; Nasuruddin D.N.; Ahmad Zabidi N.F.; Jelani A.M.; Ismail A.M.; Lai L.C.; Gan G.G.
Survey on serum protein electrophoresis and recommendations for standardised reporting
2021
Malaysian Journal of Pathology
43
2

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114673459&partnerID=40&md5=29de2e632ecb9620b1967088f76fbb4c
Introduction: Serum protein electrophoresis (SPE) is a well-established laboratory technique. However, reporting of results varies considerably between laboratories. The variation in reporting can cause confusion to the clinician with a potential of adversely impacting patient care. The purpose of the survey was to find out the variation in reporting and to prepare recommendations to the Malaysian laboratories based on the survey to reduce both the variation in reporting between laboratories and the risk of misinterpretation of reports. Materials and Methods: To determine the extent of variation in reporting of protein electrophoresis results questionnaires were distributed to the pathologists of various laboratories in Malaysia regarding the method, quantification of paraprotein concentrations and immunoglobulin assays, and information regarding current laboratory electrophoresis practices. Results: Variation was found in the following reporting practices: (a) screening protocol; (b) reporting of serum albumin; (c) numerical reporting of protein fractions and paraprotein; (d) co-migration of a paraprotein with a normal serum protein; (e) reporting of multiple paraprotein bands (f) appearance of small abnormal band and oligoclonal bands and (g) communication about of interferences. Conclusion: The pathologists of the country made recommendations on the reporting of protein electrophoresis. Harmonised reporting will reduce inconsistency, variation in reporting, improve the quality of the report and most importantly improve patient care. © 2021, Malaysian Society of Pathologists. All rights reserved.
Malaysian Society of Pathologists
1268635
English
Article
author Sthaneshwar P.; Thambiah S.C.; Mat Salleh M.J.; Nasuruddin D.N.; Ahmad Zabidi N.F.; Jelani A.M.; Ismail A.M.; Lai L.C.; Gan G.G.
spellingShingle Sthaneshwar P.; Thambiah S.C.; Mat Salleh M.J.; Nasuruddin D.N.; Ahmad Zabidi N.F.; Jelani A.M.; Ismail A.M.; Lai L.C.; Gan G.G.
Survey on serum protein electrophoresis and recommendations for standardised reporting
author_facet Sthaneshwar P.; Thambiah S.C.; Mat Salleh M.J.; Nasuruddin D.N.; Ahmad Zabidi N.F.; Jelani A.M.; Ismail A.M.; Lai L.C.; Gan G.G.
author_sort Sthaneshwar P.; Thambiah S.C.; Mat Salleh M.J.; Nasuruddin D.N.; Ahmad Zabidi N.F.; Jelani A.M.; Ismail A.M.; Lai L.C.; Gan G.G.
title Survey on serum protein electrophoresis and recommendations for standardised reporting
title_short Survey on serum protein electrophoresis and recommendations for standardised reporting
title_full Survey on serum protein electrophoresis and recommendations for standardised reporting
title_fullStr Survey on serum protein electrophoresis and recommendations for standardised reporting
title_full_unstemmed Survey on serum protein electrophoresis and recommendations for standardised reporting
title_sort Survey on serum protein electrophoresis and recommendations for standardised reporting
publishDate 2021
container_title Malaysian Journal of Pathology
container_volume 43
container_issue 2
doi_str_mv
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114673459&partnerID=40&md5=29de2e632ecb9620b1967088f76fbb4c
description Introduction: Serum protein electrophoresis (SPE) is a well-established laboratory technique. However, reporting of results varies considerably between laboratories. The variation in reporting can cause confusion to the clinician with a potential of adversely impacting patient care. The purpose of the survey was to find out the variation in reporting and to prepare recommendations to the Malaysian laboratories based on the survey to reduce both the variation in reporting between laboratories and the risk of misinterpretation of reports. Materials and Methods: To determine the extent of variation in reporting of protein electrophoresis results questionnaires were distributed to the pathologists of various laboratories in Malaysia regarding the method, quantification of paraprotein concentrations and immunoglobulin assays, and information regarding current laboratory electrophoresis practices. Results: Variation was found in the following reporting practices: (a) screening protocol; (b) reporting of serum albumin; (c) numerical reporting of protein fractions and paraprotein; (d) co-migration of a paraprotein with a normal serum protein; (e) reporting of multiple paraprotein bands (f) appearance of small abnormal band and oligoclonal bands and (g) communication about of interferences. Conclusion: The pathologists of the country made recommendations on the reporting of protein electrophoresis. Harmonised reporting will reduce inconsistency, variation in reporting, improve the quality of the report and most importantly improve patient care. © 2021, Malaysian Society of Pathologists. All rights reserved.
publisher Malaysian Society of Pathologists
issn 1268635
language English
format Article
accesstype
record_format scopus
collection Scopus
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