Investigating how amine structure influences drug-amine ion-pair formation and uptake via the polyamine transporter in A549 lung cells

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Investigating how amine structure influences drug-amine ion-pair formation and uptake via the polyamine transporter in A549 lung cells

Transiently associating amines with therapeutic agents through the formation of ion-pairs has been established both in vitro and in vivo as an effective means to systemically direct drug delivery to the lung via the polyamine transport system (PTS). However, there remains a need to better understand...

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Bibliographic Details
Published in:	European Journal of Pharmaceutics and Biopharmaceutics
Main Author:	Mohamed Sofian Z.; Harun N.; Mahat M.M.; Nor Hashim N.A.; Jones S.A.
Format:	Article
Language:	English
Published:	Elsevier B.V. 2021
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114035911&doi=10.1016%2fj.ejpb.2021.08.003&partnerID=40&md5=53c965bd5bd55c41715ac8a6d665f03f

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