Crocodylus porosus gut bacteria: A possible source of novel metabolites

• Published in: Molecules
• Main Author: Khan N.A.; Soopramanien M.; Maciver S.K.; Anuar T.S.; Sagathevan K.; Siddiqui R.
• Format: Article
• Language: English
• Published: MDPI AG 2021
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113300942&doi=10.3390%2fmolecules26164999&partnerID=40&md5=11ad9fd936adce6e59872c7b29c59491

Crocodiles are remarkable animals that have the ability to endure extremely harsh conditions and can survive up to a 100 years while being exposed to noxious agents that are detrimental to Homo sapiens. Besides their immunity, we postulate that the microbial gut flora of crocodiles may produce substances with protective effects. In this study, we isolated and characterized selected bacteria colonizing the gastrointestinal tract of Crocodylus porosus and demonstrated their inhibitory effects against three different cancerous cell lineages. Using liquid chromatography-mass spectrometry, several molecules were identified. For the first time, we report partial analyses of crocodile’s gut bacterial molecules. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.