Semicarbazones, thiosemicarbazone, thiazole and oxazole analogues as monoamine oxidase inhibitors: Synthesis, characterization, biological evaluation, molecular docking, and kinetic studies

A series of semicarbazone, thiosemicarbazone, thiazole, and oxazole derivatives were designed, synthesized, and examined for monoamine oxidase inhibition using two isoforms, i.e., MAO-A and MAO-B. Among all the analogues, 3c and 3j possessed substantial activity against MAO-A with IC50 values of 5.6...

詳細記述

書誌詳細
出版年:Bioorganic Chemistry
第一著者: Qazi S.U.; Naz A.; Hameed A.; Osra F.A.; Jalil S.; Iqbal J.; Shah S.A.A.; Mirza A.Z.
フォーマット: 論文
言語:English
出版事項: Academic Press Inc. 2021
オンライン・アクセス:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111864760&doi=10.1016%2fj.bioorg.2021.105209&partnerID=40&md5=3fe1ec1423acfbc4cbcfbad2b2205f25