Semicarbazones, thiosemicarbazone, thiazole and oxazole analogues as monoamine oxidase inhibitors: Synthesis, characterization, biological evaluation, molecular docking, and kinetic studies

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Semicarbazones, thiosemicarbazone, thiazole and oxazole analogues as monoamine oxidase inhibitors: Synthesis, characterization, biological evaluation, molecular docking, and kinetic studies

A series of semicarbazone, thiosemicarbazone, thiazole, and oxazole derivatives were designed, synthesized, and examined for monoamine oxidase inhibition using two isoforms, i.e., MAO-A and MAO-B. Among all the analogues, 3c and 3j possessed substantial activity against MAO-A with IC50 values of 5.6...

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Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Qazi S.U.; Naz A.; Hameed A.; Osra F.A.; Jalil S.; Iqbal J.; Shah S.A.A.; Mirza A.Z.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2021
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111864760&doi=10.1016%2fj.bioorg.2021.105209&partnerID=40&md5=3fe1ec1423acfbc4cbcfbad2b2205f25

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