Development of custom lead shield and strainer for targeted irradiation for mice in the gamma cell chamber

• Published in: Scientific Reports
• Main Author: Hasan N.; Sham N.F.R.; Karim M.K.A.; Fuad S.B.S.A.; Hasani N.A.H.; Omar E.; Ibahim M.J.
• Format: Article
• Language: English
• Published: Nature Research 2021
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110729100&doi=10.1038%2fs41598-021-93964-5&partnerID=40&md5=1ebc90baea25f6552983f2158c1b01a6

We presented a development of a custom lead shield and mouse strainer for targeted irradiation from the gamma-cell chamber. This study was divided into two parts i.e., to (i) fabricate the shield and strainer from a lead (Pb) and (ii) optimize the irradiation to the mice-bearing tumour model with 2 and 8 Gy absorbed doses. The lead shielding was fabricated into a cuboid shape with a canal on the top and a hole on the vertical side for the beam path. Respective deliveries doses of 28 and 75 Gy from gamma-cell were used to achieve 2 and 8 Gy absorbed doses at the tumour sites. © 2021, The Author(s).