Relevance of leukocytospermia and semen culture and its true place in diagnosing and treating male infertility

Relevance of leukocytospermia and semen culture and its true place in diagnosing and treating male infertility

The current WHO 2010 manual for human semen analysis defines leukocytospermia as the presence of peroxidase-positive leukocytes at a concentration >1×106/mL of semen. Granular leukocytes when activated are capable of generating high levels of reactive oxygen species in semen resulting in oxidativ...

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Published in:World Journal of Men's Health
Main Author: Sharma R.; Gupta S.; Agarwal A.; Henkel R.; Finelli R.; Parekh N.; Saleh R.; Arafa M.; Ko E.; Zini A.; Tadros N.; Shah R.; Ambar R.F.; Elbardisi H.; Sengupta P.; Martinez M.; Boitrelle F.; Simopoulou M.; Vogiatzi P.; Gosalvez J.; Kavoussi P.; Kandil H.; Palani A.; Peña M.R.; Rajmil O.; Busetto G.M.; Anagnostopoulou C.; Micic S.; Alves M.G.; Rocco L.; Mostafa T.; Alvarez J.G.; Jindal S.; Sallam H.N.; Rosas I.M.; Lewis S.E.M.; AlSaid S.; Altan M.; Park H.J.; Ramsay J.; Parekattil S.; Sabbaghian M.; Tremellen K.; Khalafalla K.; Durairajanayagam D.; Colpi G.M.
Format: Article
Language:English
Published: Korean Society for Sexual Medicine and Andrology 2021
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109488169&doi=10.5534%2fWJMH.210063&partnerID=40&md5=bacb81539baaec8808c71dee9658a4d7
id 2-s2.0-85109488169
spelling 2-s2.0-85109488169
Sharma R.; Gupta S.; Agarwal A.; Henkel R.; Finelli R.; Parekh N.; Saleh R.; Arafa M.; Ko E.; Zini A.; Tadros N.; Shah R.; Ambar R.F.; Elbardisi H.; Sengupta P.; Martinez M.; Boitrelle F.; Simopoulou M.; Vogiatzi P.; Gosalvez J.; Kavoussi P.; Kandil H.; Palani A.; Peña M.R.; Rajmil O.; Busetto G.M.; Anagnostopoulou C.; Micic S.; Alves M.G.; Rocco L.; Mostafa T.; Alvarez J.G.; Jindal S.; Sallam H.N.; Rosas I.M.; Lewis S.E.M.; AlSaid S.; Altan M.; Park H.J.; Ramsay J.; Parekattil S.; Sabbaghian M.; Tremellen K.; Khalafalla K.; Durairajanayagam D.; Colpi G.M.
Relevance of leukocytospermia and semen culture and its true place in diagnosing and treating male infertility
2021
World Journal of Men's Health
40
2
10.5534/WJMH.210063
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109488169&doi=10.5534%2fWJMH.210063&partnerID=40&md5=bacb81539baaec8808c71dee9658a4d7
The current WHO 2010 manual for human semen analysis defines leukocytospermia as the presence of peroxidase-positive leukocytes at a concentration >1×106/mL of semen. Granular leukocytes when activated are capable of generating high levels of reactive oxygen species in semen resulting in oxidative stress. Oxidative stress has been correlated with poor sperm quality, increased level of sperm DNA fragmentation and low fertility potential. The presence of leukocytes and pathogens in the semen may be a sign of infection and/or localized inflammatory response in the male genital tract and the accessory glands. Common uro-pathogens including Chlamydia trachomatis, Ureaplasma urealyticum, Neisseria gonorrhoeae, Mycoplasma hominis, and Escherichia coli can cause epididymitis, epididymo-orchitis, or prostatitis. The relationship between leukocytospermia and infection is unclear. Therefore, we describe the pathogens responsible for male genital tract infections and their association with leukocytospermia. The review also examines the diagnostic tests available to identify seminal leukocytes. The role of leukocytospermia in male infertility and its management is also discussed. © 2021 Korean Society for Sexual Medicine and Andrology. All rights reserved.
Korean Society for Sexual Medicine and Andrology
22874208
English
Article
All Open Access; Gold Open Access
author Sharma R.; Gupta S.; Agarwal A.; Henkel R.; Finelli R.; Parekh N.; Saleh R.; Arafa M.; Ko E.; Zini A.; Tadros N.; Shah R.; Ambar R.F.; Elbardisi H.; Sengupta P.; Martinez M.; Boitrelle F.; Simopoulou M.; Vogiatzi P.; Gosalvez J.; Kavoussi P.; Kandil H.; Palani A.; Peña M.R.; Rajmil O.; Busetto G.M.; Anagnostopoulou C.; Micic S.; Alves M.G.; Rocco L.; Mostafa T.; Alvarez J.G.; Jindal S.; Sallam H.N.; Rosas I.M.; Lewis S.E.M.; AlSaid S.; Altan M.; Park H.J.; Ramsay J.; Parekattil S.; Sabbaghian M.; Tremellen K.; Khalafalla K.; Durairajanayagam D.; Colpi G.M.
spellingShingle Sharma R.; Gupta S.; Agarwal A.; Henkel R.; Finelli R.; Parekh N.; Saleh R.; Arafa M.; Ko E.; Zini A.; Tadros N.; Shah R.; Ambar R.F.; Elbardisi H.; Sengupta P.; Martinez M.; Boitrelle F.; Simopoulou M.; Vogiatzi P.; Gosalvez J.; Kavoussi P.; Kandil H.; Palani A.; Peña M.R.; Rajmil O.; Busetto G.M.; Anagnostopoulou C.; Micic S.; Alves M.G.; Rocco L.; Mostafa T.; Alvarez J.G.; Jindal S.; Sallam H.N.; Rosas I.M.; Lewis S.E.M.; AlSaid S.; Altan M.; Park H.J.; Ramsay J.; Parekattil S.; Sabbaghian M.; Tremellen K.; Khalafalla K.; Durairajanayagam D.; Colpi G.M.
Relevance of leukocytospermia and semen culture and its true place in diagnosing and treating male infertility
author_facet Sharma R.; Gupta S.; Agarwal A.; Henkel R.; Finelli R.; Parekh N.; Saleh R.; Arafa M.; Ko E.; Zini A.; Tadros N.; Shah R.; Ambar R.F.; Elbardisi H.; Sengupta P.; Martinez M.; Boitrelle F.; Simopoulou M.; Vogiatzi P.; Gosalvez J.; Kavoussi P.; Kandil H.; Palani A.; Peña M.R.; Rajmil O.; Busetto G.M.; Anagnostopoulou C.; Micic S.; Alves M.G.; Rocco L.; Mostafa T.; Alvarez J.G.; Jindal S.; Sallam H.N.; Rosas I.M.; Lewis S.E.M.; AlSaid S.; Altan M.; Park H.J.; Ramsay J.; Parekattil S.; Sabbaghian M.; Tremellen K.; Khalafalla K.; Durairajanayagam D.; Colpi G.M.
author_sort Sharma R.; Gupta S.; Agarwal A.; Henkel R.; Finelli R.; Parekh N.; Saleh R.; Arafa M.; Ko E.; Zini A.; Tadros N.; Shah R.; Ambar R.F.; Elbardisi H.; Sengupta P.; Martinez M.; Boitrelle F.; Simopoulou M.; Vogiatzi P.; Gosalvez J.; Kavoussi P.; Kandil H.; Palani A.; Peña M.R.; Rajmil O.; Busetto G.M.; Anagnostopoulou C.; Micic S.; Alves M.G.; Rocco L.; Mostafa T.; Alvarez J.G.; Jindal S.; Sallam H.N.; Rosas I.M.; Lewis S.E.M.; AlSaid S.; Altan M.; Park H.J.; Ramsay J.; Parekattil S.; Sabbaghian M.; Tremellen K.; Khalafalla K.; Durairajanayagam D.; Colpi G.M.
title Relevance of leukocytospermia and semen culture and its true place in diagnosing and treating male infertility
title_short Relevance of leukocytospermia and semen culture and its true place in diagnosing and treating male infertility
title_full Relevance of leukocytospermia and semen culture and its true place in diagnosing and treating male infertility
title_fullStr Relevance of leukocytospermia and semen culture and its true place in diagnosing and treating male infertility
title_full_unstemmed Relevance of leukocytospermia and semen culture and its true place in diagnosing and treating male infertility
title_sort Relevance of leukocytospermia and semen culture and its true place in diagnosing and treating male infertility
publishDate 2021
container_title World Journal of Men's Health
container_volume 40
container_issue 2
doi_str_mv 10.5534/WJMH.210063
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109488169&doi=10.5534%2fWJMH.210063&partnerID=40&md5=bacb81539baaec8808c71dee9658a4d7
description The current WHO 2010 manual for human semen analysis defines leukocytospermia as the presence of peroxidase-positive leukocytes at a concentration >1×106/mL of semen. Granular leukocytes when activated are capable of generating high levels of reactive oxygen species in semen resulting in oxidative stress. Oxidative stress has been correlated with poor sperm quality, increased level of sperm DNA fragmentation and low fertility potential. The presence of leukocytes and pathogens in the semen may be a sign of infection and/or localized inflammatory response in the male genital tract and the accessory glands. Common uro-pathogens including Chlamydia trachomatis, Ureaplasma urealyticum, Neisseria gonorrhoeae, Mycoplasma hominis, and Escherichia coli can cause epididymitis, epididymo-orchitis, or prostatitis. The relationship between leukocytospermia and infection is unclear. Therefore, we describe the pathogens responsible for male genital tract infections and their association with leukocytospermia. The review also examines the diagnostic tests available to identify seminal leukocytes. The role of leukocytospermia in male infertility and its management is also discussed. © 2021 Korean Society for Sexual Medicine and Andrology. All rights reserved.
publisher Korean Society for Sexual Medicine and Andrology
issn 22874208
language English
format Article
accesstype All Open Access; Gold Open Access
record_format scopus
collection Scopus
_version_ 1798286509512589312

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