Synthesis and α-glucosidase inhibition activity of 2-[3-(Benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2h-benzo[e][1,2]thiazin-2-yl]-n-arylacetamides: An in silico and biochemical approach

QR Code

Synthesis and α-glucosidase inhibition activity of 2-[3-(Benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2h-benzo[e][1,2]thiazin-2-yl]-n-arylacetamides: An in silico and biochemical approach

Diabetes mellitus (DM) is a chronic disorder and has affected a large number of people worldwide. Insufficient insulin production causes an increase in blood glucose level that results in DM. To lower the blood glucose level, various drugs are employed that block the activity of the α-glucosidase en...

Full description

Bibliographic Details
Published in:	Molecules
Main Author:	Saddique F.A.; Aslam S.; Ahmad M.; Ashfaq U.A.; Muddassar M.; Sultan S.; Taj S.; Hussain M.; Lee D.S.; Zaki M.E.A.
Format:	Article
Language:	English
Published:	MDPI AG 2021
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107198620&doi=10.3390%2fmolecules26103043&partnerID=40&md5=b79169227fc2f936309a6a27a12efe70

Similar Items

Synthesis, monoamine oxidase inhibition activity and molecular docking studies of novel 4-hydroxy-N′-[benzylidene or 1-phenylethylidene]-2-H/methyl/benzyl-1,2-benzothiazine-3-carbohydrazide 1,1-dioxides
by: Saddique F.A.; Zaib S.; Jalil S.; Aslam S.; Ahmad M.; Sultan S.; Naz H.; Iqbal M.; Iqbal J.
Published: (2018)

Synthesis and evaluation of antimicrobial, antitubercular and anticancer activities of 2-(1-benzoyl-1H-benzo[d]imidazol-2-ylthio)-N-substituted acetamides
by: Yadav S.; Lim S.M.; Ramasamy K.; Vasudevan M.; Shah S.A.A.; Mathur A.; Narasimhan B.
Published: (2018)

Synthesis, crystal structure and Hirshfeld surface analysis of ethyl 4-hydroxy-2-(4-hydroxyphenyl)-1-methyl-5-oxo-2,5-dihydro1H-pyrrole-3-carboxylate
by: Rashid, et al.
Published: (2023)

4-(2-(1H-Benzo[d]imidazol-2-ylthio) acetamido)-N-(substituted phenyl)benzamides: Design, synthesis and biological evaluation
by: Tahlan S.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Narasimhan B.
Published: (2019)

4-[5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl]benzohydrazide
by: Taha M.; Ismail N.H.; Imran S.; Khan K.M.
Published: (2014)

Synthesis, X-ray crystal and monoamine oxidase inhibitory activity of 4,6-dihydrobenzo[c]pyrano[2,3-e][1,2]thiazine 5,5-dioxides: In vitro studies and docking analysis
by: Ahmad S.; Jalil S.; Zaib S.; Aslam S.; Ahmad M.; Rasul A.; Arshad M.N.; Sultan S.; Hameed A.; Asiri A.M.; Iqbal J.
Published: (2019)

Synthesis, characterization, biological evaluation and molecular docking studies of 2-(1H-benzo[d]imidazol-2-ylthio)-N-(substituted 4-oxothiazolidin-3-yl) acetamides
by: Yadav S.; Narasimhan B.; Lim S.M.; Ramasamy K.; Vasudevan M.; Shah S.A.A.; Selvaraj M.
Published: (2017)

6-Benzyl-3-(1,4-dioxaspiro-[4.5]decan-2-yl)-8,8-dimethyl-1-oxa-2, 6-diaza-spiro-[4.4]non-2-ene-7,9-dione
by: Bathich Y.; Shaameri Z.; Hamzah A.S.; Quah C.K.; Fun H.-K.
Published: (2009)

4-Fluorobenzyl (Z)-2-(2-oxoindolin-3-ylidene) hydrazine-1-carbodithioate
by: Manan M.A.F.A.; Cordes D.B.; McKay A.P.
Published: (2024)

Synthesis, pharmacological screening & computational analysis of some 2-(1H-Indol-3-yl)-N'-[(un)substituted phenylmethylidene] acetohydrazides & 2-(1H-Indol-3-yl)-N'-[(un)substituted benzoyl/2-Thienylcarbonyl]acetohydrazides
by: Rubab K.; Abbasi M.A.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Ashraf M.; Qurat-Ul-Ain; Ahmad I.; Lodhi M.A.; Ghufran M.; Shahid M.; Fatima H.
Published: (2017)

Synthesis of 1-(4-Bromobenzoyl)-1,3-dicyclohexylurea and Its Arylation via Readily Available Palladium Catalyst─Their Electronic, Spectroscopic, and Nonlinear Optical Studies via a Computational Approach
by: Maqbool T.; Younas H.; Bilal M.; Rasool N.; Bajaber M.A.; Mubarik A.; Parveen B.; Ahmad G.; Ali Shah S.A.
Published: (2023)

Design, synthesis and therapeutic potential of 3-(2-(1H-benzo[d]imidazol-2-ylthio)acetamido)-N-(substituted phenyl)benzamide analogues
by: Tahlan S.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Narasimhan B.
Published: (2018)

Synthesis of novel N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-{[5-(un/substituted-phenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamides as potent antibacterial agents
by: Abbasi M.A.; Irshad M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.
Published: (2022)

Synthesis of 2-{[5-(aralkyl/aryl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-(4-methyl-1,3-thiazol-2-yl)acetamides: Novel bi-heterocycles as potential therapeutic agents
by: Ramzan M.S.; Abbasi M.A.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Ashraf M.; Lodhi M.A.; Khan F.A.; Mirza B.
Published: (2018)

Synthesis, spectral analysis and pharmacological study of N’-substituted-2-(5-((2,4-dimethylphenoxy)methyl)-1,3,4-oxadiazol-2-ylthio)acetohydrazides
by: Rasool S.; Aziz-ur-Rehman; Abbasi M.A.; Siddiqui S.Z.; Shah S.A.A.
Published: (2016)

Crystal structure of ethyl 1-(2-hydroxyethyl)-4-((4-methoxyphenyl)amino)-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate, C16H20N2O5
by: Abdul Rashid F.N.A.; Bacho M.Z.; Slawin A.M.Z.; Abdul Manan M.A.F.; Johari S.A.; Mohammat M.F.
Published: (2023)

Synthesis of Novel Bi-Heterocycles as Valuable Anti-Diabetic Agents: 2-({5-((2-Amino-1,3-Thiazol-4-yl)methyl)-1,3,4-Oxadiazol-2-yl}sulfanyl)-N-(Substituted)acetamides
by: Muhammad Athar Abbasi; Ramzan M.S.; Aziz-ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Lodhi M.A.; Khan F.A.; Mirza B.
Published: (2020)

Structure–activity relationship and in silico study of unique bi-heterocycles: 5-[(2-amino-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazole-2-thiol derivatives
by: Abbasi M.A.; Ramzan M.S.; Aziz-Ur-Rehman; Siddiqui S.Z.; Hassan M.; Raza H.; Shah S.A.A.; Mirza B.; Seo S.-Y.
Published: (2019)

Synthesis of 2-(2-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole derivatives and evaluation of their antiglycation potential
by: Taha M.; Ismail N.H.; Jamil W.; Imran S.; Rahim F.; Kashif S.M.; Zulkefeli M.
Published: (2016)

Crystal structure of 2,2'-(((2,2-dimethylpropane-1,3-diyl)bis(azanylylidene))- bis(methanylylidene))bis(4-methoxyphenol)palladium(II)
by: Ahmad S.N.; Bahron H.; Tajuddin A.M.; Sukeri M.M.Y.
Published: (2017)

Synthesis, antimicrobial and cytotoxic evaluation of 4-(1-aryl-5-halo-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides
by: Kumar M.; Narasimhan B.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.
Published: (2017)

Synthesis and structural analysis of persuasive antibacterial agents and enzyme inhibitors derived from 5-(1-(4-Tosyl)piperidin-4-yl)-1,3,4-oxadiazol-2-thiol
by: Aziz-Ur-Rehman; Sattar A.; Abbasi M.A.; Siddiqui S.Z.; Raza M.A.; Ashraf M.; Nazir M.; Shah S.A.A.
Published: (2018)

Biological activity of synthesized 5-{1-[(4-chlorophenyl)sulfonyl]piperidin-4-yl}-2-mercapto-1,3,4-oxadiazole derivatives demonstrated by in silico and bsa binding studies
by: Iqbal J.; Ur-Rehman A.; Abbasi M.A.; Siddiqui S.Z.; Rasool S.; Ashraf M.; Iqbal A.; Hamid S.; Chohan T.A.; Khalid H.; Laulloo S.J.; Shah S.A.A.
Published: (2020)

Synthesis, antimicrobial, anticancer, antiviral evaluation and QSAR studies of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides
by: Kumar M.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.; Clercq E.D.; Narasimhan B.
Published: (2014)

N-(5-Methyl-1,3-Thiazol-2-yl)-2-{[5-((Un)Substituted- Phenyl)1,3,4-Oxadiazol-2-yl]Sulfanyl}acetamides. Unique Biheterocycles as Promising Therapeutic Agents
by: Abbasi M.A.; Ramzan M.S.; Aziz-ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Hassan M.; Seo S.-Y.; Ashraf M.; Mirza B.; Ismail H.
Published: (2018)

Synthesis of some new 2-[4-(2-furoyl)-1-piperazinyl]-N-aryl/aralkyl acetamides as potent antibacterial agents
by: Hussain G.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Ali Shah S.A.; Ahmad I.; Shahid M.
Published: (2018)

4-(1-Aryl-5-chloro-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides: Synthesis, antimicrobial, anticancer evaluation and QSAR studies
by: Kumar M.; Narasimhan B.; Kumar P.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.
Published: (2014)

Synthesis, β-Glucuronidase Inhibition, and Molecular Docking Studies of 1,2,4-Triazole Hydrazones
by: Jamil W.; Kumari D.; Taha M.; Khan M.N.; Baharudin M.S.; Ali M.; Kanwal M.; Lashari M.S.; Khan K.M.
Published: (2018)

Synthesis and biological evaluation of heterocyclic 1,2,4-triazole scaffolds as promising pharmacological agents
by: Kumari M.; Tahlan S.; Narasimhan B.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Kakkar S.
Published: (2021)

Protective effects of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone chalcone in indomethacin-induced gastric erosive damage in rats
by: Dhiyaaldeen S.M.; Amin Z.A.; Darvish P.H.; Mustafa I.F.; Jamil M.M.; Rouhollahi E.; Abdulla M.A.
Published: (2014)

ELECTROCHEMICAL SENSOR OF MULTIWALLED CARBON NANOTUBE ELECTRODE MODIFIED BY 1-PHENYL-3-METHYL-4-ORTHOFLUORO BENZOYL-5-PYRAZOLONE FOR SENSING DOPAMINE
by: Mahbob E.N.M.; Ahmad M.S.; Isa I.M.; Hashim N.; Ul-Hamid A.; Saidin M.I.; Si S.M.
Published: (2023)

Dataset of spectroscopic, crystallography and DFT of novel 1,2-bis[N,N’-6-(4-pyridylmethylamido)pyridyl-2-carboxyamido]butane
by: Kadir M.A.; Haris N.S.H.; Yusof M.S.M.; Kassim K.; Abdul Razak F.I.
Published: (2023)

Synthesis, molecular docking and α-glucosidase inhibition of 5-aryl-2-(6′-nitrobenzofuran-2′-yl)-1,3,4-oxadiazoles
by: Taha M.; Ismail N.H.; Imran S.; Wadood A.; Rahim F.; Saad S.M.; Khan K.M.; Nasir A.
Published: (2016)

Synthesis of 2-phenyl-1H-imidazo[4,5-b]pyridine as type 2 diabetes inhibitors and molecular docking studies
by: Taha M.; Ismail N.H.; Imran S.; Ainaa I.; Selvaraj M.; baharudin M.; Ali M.; Khan K.M.; Uddin N.
Published: (2017)

Design, synthesis and therapeutic potential of some 6, 6'-(1,4- phenylene)bis(4-(4-bromophenyl)pyrimidin-2-amine)analogues
by: Kumar S.; Narasimhan B.; Lim S.M.; Ramasamy K.; Mani V.; Shah S.A.A.
Published: (2019)

Synthesis and corrosion inhibition studies of N-((4 and 3-chlorophenyl) carbamothioyl) benzamide in 1M H2SO4
by: Zulkifli N.Z.; Kassim K.; Nordin N.A.
Published: (2017)

Synthesis and pharmacological screening: Sulfa derivatives of 2-pipecoline-bearing 1,3,4-oxadiazole core
by: Aziz-ur-Rehman; Arif A.; Abbasi M.A.; Siddiqui S.Z.; Rasool S.; Shah S.A.A.
Published: (2017)

Synthesis of 2,4-dihydroxyacetophenone derivatives as potent PDE-1 and -3 inhibitors: in vitro and in silico insights
by: Alam A.; Gul S.; Zainab; Khan M.; Elhenawy A.A.; Islam M.S.; Ali M.; Ali Shah S.A.; Latif A.; Ahmad M.
Published: (2024)

Linear synthesis of {4-[(2-Alkoxy/aralkyloxy-3,5-dichlorophenyl)sulfonyl]-1-piperazinyl}(2-furyl)methanones as possible therapeutic agents
by: Abbasi M.A.; Khan W.; Aziz-Ur-Rehman; Siddiqui S.Z.; Hussain G.; Shah S.A.A.; Shahid M.; Khan K.M.
Published: (2019)

The intergenerational effects of oligomeric proanthocyanidins on expression of Sult2a2, Sult2al1 and Sult2a1 in Bisphenol A-exposed male rats
by: Siti-Aishah Z.; Razif D.; Mohd Hafizi M.; Fatin N.O.; Nur Hilwani I.; Fatin Nadzirah Z.; Nina Keterina H.; Mastura A.M.
Published: (2020)