Synthesis and structure-activity relationship of 1-[(E)-3-phenyl-2-propenyl] piperazine derivatives as suitable antibacterial agents with mild hemolysis

QR Code

Synthesis and structure-activity relationship of 1-[(E)-3-phenyl-2-propenyl] piperazine derivatives as suitable antibacterial agents with mild hemolysis

A new series of 1-[(E)-3-phenyl-2-propenyl]piperazine derivatives (5a-m) as antibacterial agents was designed and synthesized. The synthetic strategy was initiated by coupling different anilines (1a-m) with bromoacetyl bromide (2) in an aqueous basic medium to acquire different electrophiles, 3a-m,...

Full description

Bibliographic Details
Published in:	Scientia Iranica
Main Author:	Abbasi M.A.; Nazir M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.
Format:	Article
Language:	English
Published:	Sharif University of Technology 2019
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105482274&doi=10.24200%2fsci.2019.51207.2062&partnerID=40&md5=b903f115a7aea925eeacde8dff2aba0f

Similar Items

Synthesis of some N-sulfonated derivatives of 1-[(E)-3-phenyl-2-propenyl]piperazine as suitable antibacterial agents
by: Abbasi M.A.; Ijaz M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.; Fatima H.
Published: (2020)

N-Sulfonated derivatives of (2-furoyl)piperazine: Promising antibacterial agents with mild cytotoxicity
by: Abbasi M.A.; Irshad M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.
Published: (2022)

Synthesis Of Some N-(Un/Substituted-Phenyl)-2-(4-Phenyl-1-Piperazinyl)Acetamides as Possible Antibacterial and Anticancer Agents with Mild Cytotoxicity
by: Abbasi M.A.; Nazir M.; Aziz-ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Saleem R.S.Z.; Shahid M.; Mirza B.; Ismail H.
Published: (2022)

Synthesis of 2-Furyl[(4-aralkyl)-1-piperazinyl]methanone derivatives as suitable antibacterial agents with mild cytotoxicity
by: Abbasi M.A.; Nazeer M.M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Hussain G.; Shah S.A.A.; Ahmad I.; Shahid M.; Sarwar M.S.
Published: (2018)

Synthesis, molecular docking, dynamic simulations, kinetic mechanism, cytotoxicity evaluation of N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl} butanamides as tyrosinase and melanin inhibitors: In vitro, in vivo and in silico approaches
by: Raza H.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Hassan M.; Abbas Q.; Hong H.; Shah S.A.A.; Shahid M.; Seo S.-Y.
Published: (2020)

Synthesis of promising antibacterial and antifungal agents: 2-[[(4-Chlorophenyl)sulfonyl](2,3-dihydro-1,4-benzodioxin-6-yl)amino]-N(un/substituted-phenyl)acetamides
by: Abbasi M.A.; Irshad M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Nazir M.; Ali Shah S.A.; Shahid M.
Published: (2020)

Synthesis of new S-substituted derivatives of 5-[3-(1H-indol-3-yl) propyl]-1, 3, 4-oxadiazol-2-ylhydrosulfide as suitable antibacterial and anticancer agents with moderate cytotoxicity
by: Nazir M.; Abbasi M.A.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.; Fatima H.; Iftikhar S.; Saleem R.S.Z.
Published: (2019)

Synthesis of 3-[4-(2-furoyl)-1-piperazinyl]-N-(substituted)propanamides as promising antibacterial agents with mild cytotoxicity
by: Hussain G.; Abbasi M.A.; Aziz-Ur-Rehman; Siddiqui S.Z.; Ahmad I.; Malik R.; Shahid M.; Mushtaq Z.; Shah S.A.A.
Published: (2018)

Synthesis of novel N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-{[5-(un/substituted-phenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamides as potent antibacterial agents
by: Abbasi M.A.; Irshad M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.
Published: (2022)

Synthesis, In Vitro, and In Silico Studies of N-(Substituted-Phenyl)-3-(4-Phenyl-1-Piperazinyl)propanamides as Potent Alkaline Phosphatase Inhibitors
by: Abbasi M.A.; Nazir M.; Aziz-ur-Rehman; Siddiqui S.Z.; Raza H.; Zafar A.; Shah S.A.A.; Shahid M.
Published: (2021)

Synthesis of some unique carbamate derivatives bearing 2-furoyl-1-piperazine as a valuable therapeutic agents
by: Abbasi M.A.; Hussain G.; Aziz-Ur-Rehman; Siddiqui S.Z.; Ali Shah S.A.; Lodhi M.A.; Ali Khan F.; Ashraf M.; Qurat-Ul-Ain; Ahmad I.; Malik R.; Shahid M.; Mushtaq Z.
Published: (2017)

Synthesis and Molecular Docking Studies of Novel Biheterocyclic Propanamides as Antidiabetic Agents Having Mild Cytotoxicity
by: Abbasi M.A.; Rubab K.; Aziz-Ur-Rehman N.; Siddiqui S.Z.; Hassan M.; Raza H.; Shah S.A.A.; Shahid M.; Kloczkowski A.
Published: (2023)

Convergent synthesis, free radical scavenging, Lineweaver-Burk plot exploration, hemolysis and in silico study of novel indole-phenyltriazole hybrid bearing acetamides as potent urease inhibitors
by: Khan W.; Abbasi M.A.; Rehman A.-U.; Siddiqui S.Z.; Nazir M.; Ali Shah S.A.; Raza H.; Hassan M.; Shahid M.; Seo S.Y.
Published: (2020)

Synthesis and Structure-Activity Relationship of 1-(2-Furoyl)Piperazine Bearing Benzamides as Butyrylcholinesterase Inhibitors
by: Abbasi M.A.; Irshad M.; Aziz-ur-Rehman; Siddiqui S.Z.; Junaid H.M.; Shah S.A.A.; Ashraf M.
Published: (2020)

Synthesis of some new N-(alkyl/aralkyl)-N-(4-methoxyphenethyl) benzenesulfonamides as antibacterial agents against Escherichia coli
by: Abbasi M.A.; Fatima Z.; Aziz-Ur-Rehman; Siddiqui S.Z.; Ali Shah S.A.; Shahid M.; Fatima H.
Published: (2019)

Synthesis of some new 2-[4-(2-furoyl)-1-piperazinyl]-N-aryl/aralkyl acetamides as potent antibacterial agents
by: Hussain G.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Ali Shah S.A.; Ahmad I.; Shahid M.
Published: (2018)

Synthesis and in silico study of 2-furyl(4-{4-[(substituted)sulfonyl]benzyl}-1-piperazinyl)methanone derivatives as suitable therapeutic agents
by: Hussain G.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Ashraf M.; Qurat-ul-Ain; Ahmad I.; Malik R.; Lodhi M.A.; Khan F.A.; Shahid M.; Fatima H.
Published: (2017)

Novel indole based hybrid oxadiazole scaffolds with: N -(substituted-phenyl)butanamides: Synthesis, lineweaver-burk plot evaluation and binding analysis of potent urease inhibitors
by: Nazir M.; Abbasi M.A.; Aziz-Ur-Rehman; Siddiqui S.Z.; Raza H.; Hassan M.; Ali Shah S.A.; Shahid M.; Seo S.-Y.
Published: (2018)

Synthesis and structural analysis of persuasive antibacterial agents and enzyme inhibitors derived from 5-(1-(4-Tosyl)piperidin-4-yl)-1,3,4-oxadiazol-2-thiol
by: Aziz-Ur-Rehman; Sattar A.; Abbasi M.A.; Siddiqui S.Z.; Raza M.A.; Ashraf M.; Nazir M.; Shah S.A.A.
Published: (2018)

Multi-step synthesis, kinetics and in silico explorations of indole-Phenyl-1,2,4-triazole Bi-heterocyclic hybrids unified with 3-substituted benzamides as elastase inhibitors
by: Shakila; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Nazir M.; Muhammad S.; Raza H.; Shah S.A.A.; Shahid M.; Chaudhry A.R.; Kim S.J.
Published: (2025)

Multi-step synthesis, kinetics and in silico explorations of indole-Phenyl-1,2,4-triazole Bi-heterocyclic hybrids unified with 3-substituted benzamides as elastase inhibitors
by: Shakila; Abbasi, et al.
Published: (2025)

Novel Bi-heterocycles as potent inhibitors of Urease and less cytotoxic agents: 3-({5-((2-amino-1,3-thiazol-4-yl)methyl)-1,3,4-oxadiazol-2-yl}sulfanyl)-N-(un/substituted-phenyl) propanamides
by: Abbasi M.A.; Ramzan M.S.; Aziz-Ur-Rehman; Siddiqui S.Z.; Hassan M.; Shah S.A.A.; Ashraf M.; Shahid M.; Seo S.-Y.
Published: (2020)

Design, synthesis and computational studies of N-(substituted-phenyl)-4-(4-phenyl-1-piperazinyl)butanamides as potent anti-melanogenic and tyrosinase inhibitors
by: Raza H.; Abbasi M.A.; Rehman A.-U.; Siddiqui S.Z.; Hassan M.; Shah S.A.A.; Shahid M.; Hong H.; Seo S.-Y.
Published: (2020)

Synthesis of some new N-substituted-N-(2,3-Dihydro-[1,4]benzodioxin-6-yl)-4-acetamidobenzenesulfonamides as valuable antibacterial agents
by: Abbasi M.A.; Tariq S.; Aziz-Ur-Rehman; Siddiqui S.Z.; Ahmad I.; Malik R.; Shah S.A.A.
Published: (2016)

N-(5-Methyl-1,3-Thiazol-2-yl)-2-{[5-((Un)Substituted- Phenyl)1,3,4-Oxadiazol-2-yl]Sulfanyl}acetamides. Unique Biheterocycles as Promising Therapeutic Agents
by: Abbasi M.A.; Ramzan M.S.; Aziz-ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Hassan M.; Seo S.-Y.; Ashraf M.; Mirza B.; Ismail H.
Published: (2018)

Design, synthesis of triazole-based scaffolds, N-(substitutedphenyl)-2-(5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-ylthiol)acetamides: As potential anti-cholinesterase agents for neurodegenerative diseases
by: Siddiqui S.Z.; Arfan M.; Abbasi M.A.; Aziz-ur-Rehman; Shah S.A.A.; Parveen R.; Ashraf M.; Solangi M.; Hussain S.; Khan K.M.
Published: (2023)

Synthesis, In Vitro Enzymatic Inhibition, and Molecular Modeling of Novel Piperazine-Based Bis-Schiff Base Derivatives as Promising Anti-urease Agents
by: Masood N.; Hussain R.; Khan S.; Rahim F.; Mumtaz S.; Taha M.; Ur Rahman Abid O.; Iqbal T.; Adnan Ali Shah S.; Omar Al Wesabi E.; Magam S.M.
Published: (2024)

Synthesis, In Vitro Enzymatic Inhibition, and Molecular Modeling of Novel Piperazine-Based Bis-Schiff Base Derivatives as Promising Anti-urease Agents
by: Masood, et al.
Published: (2024)

Exploration of synthetic multifunctional amides as new therapeutic agents for Alzheimer's disease through enzyme inhibition, chemoinformatic properties, molecular docking and dynamic simulation insights
by: Hassan M.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Hussain G.; Shah S.A.A.; Shahid M.; Seo S.-Y.
Published: (2018)

Linear synthesis of {4-[(2-Alkoxy/aralkyloxy-3,5-dichlorophenyl)sulfonyl]-1-piperazinyl}(2-furyl)methanones as possible therapeutic agents
by: Abbasi M.A.; Khan W.; Aziz-Ur-Rehman; Siddiqui S.Z.; Hussain G.; Shah S.A.A.; Shahid M.; Khan K.M.
Published: (2019)

Multi-step synthesis of indole-N-ethyltriazole hybrids amalgamated with N-arylated ethanamides: structure-activity relationship and mechanistic explorations through tyrosinase inhibition, kinetics and computational ascriptions
by: Shakila; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Nazir M.; Raza H.; Zafar A.; Shah S.A.A.; Shahid M.; Seo S.-Y.
Published: (2022)

Bi-heterocyclic benzamides as alkaline phosphatase inhibitors: Mechanistic comprehensions through kinetics and computational approaches
by: Abbasi M.A.; Nazir M.; ur-Rehman A.; Siddiqui S.Z.; Hassan M.; Raza H.; Shah S.A.A.; Shahid M.; Seo S.-Y.
Published: (2019)

Synthetic N-aralkylated-N-(2,4-dimethylphenyl)benzenesulfonamides: As potent anti-bacterial agents
by: Siddiqui S.Z.; Sarwar A.; Abbasi M.A.; Aziz-Ur-Rehman; Hussain M.; Irshad M.; Shah S.A.A.
Published: (2016)

Synthesis of new 2-{2,3-dihydro-1,4-benzodioxin-6-yl[(4‑methylphenyl) sulfonyl]amino}-N-(un/substituted-phenyl) acetamides as α-glucosidase and acetylcholinesterase inhibitors and their in silico study
by: Abbasi M.A.; Riaz S.; Aziz-Ur-rehman; Siddiqui S.Z.; Shah S.A.A.; Ashraf M.; Lodhi M.A.; Khan F.A.
Published: (2019)

Synthesis, characterization, antibacterial, α-glucosidase inhibition and hemolytic studies on some new n-(2,3-Dimethylphenyl)benzenesulfonamide derivatives
by: Abbasi M.A.; Islam M.; Aziz-ur-Rehman; Rasool S.; Rubab K.; Hussain G.; Ahmad I.; Ashraf M.; Shahid M.; Shah S.A.A.
Published: (2016)

The assessment of 2D animation e-module suitability usage in Malaysia Community College
by: Hashim S.; Ismail M.E.; Masek A.; Lip R.; Sa’adan N.; Utami P.
Published: (2019)

Bacterial Biofilm Inhibition, Hemolytic Activity, and Structure–Activity Relationship of N-(2,3-Dihydro-1,4-Benzodioxin-6-yl)-4-Nitro-N-(Substituted-Benzyl)benzenesulfonamides
by: Muhammad A. Abbasi; Irshad M.; Aziz-ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.
Published: (2020)

Synthesis, enzyme inhibitory kinetics, & computational studies of N-(substituted phenyl)-(5-(3,4-dichlorobenzyl)-4-(4-chlorophenyl)-4H-1,2,4-triazol-3-ylthio)methylbenzamides: As potent alkaline phosphatase inhibitors
by: Zeb A.; Siddiqui S.Z.; Abbasi M.A.; Aziz-ur-Rehman; Shah S.A.A.; Imran S.; Raza H.; Kim S.J.; Parveen R.; Abbas G.
Published: (2025)

Convergent synthesis, kinetics and computational attributions of indole-N-phenyltriazole hybrids bearing N-(aryl)butanamides as alkaline phosphatase inhibitors
by: Shakila; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Nazir M.; Raza H.; Shah S.A.A.; Ayine-Tora D.M.; Shahid M.; Kim S.J.
Published: (2025)

Multi-selective reaction of azinane bearing oxadiazoles and substituted haloalkanes catalyzed by alkali metal hydride to access anti-enzymatic agents
by: Umair M.; Aziz-ur-Rehman; Abbasi M.A.; Siddiqui S.Z.; Iqbal J.; Rasool S.; Khan S.U.; Shah S.A.A.
Published: (2024)